1. Acute liver failure following minocycline treatment - a case report and review of the literature.
- Author
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Kuhn A, Weiler-Normann C, Schramm C, Kluge S, Behne MJ, Lohse AW, and Benten D
- Subjects
- Anti-Bacterial Agents adverse effects, Diagnosis, Differential, Female, Humans, Liver Failure, Acute diagnosis, Young Adult, Liver Failure, Acute chemically induced, Liver Failure, Acute prevention & control, Minocycline adverse effects
- Abstract
We present the case of a 23-year-old female patient with acute liver failure following intake of minocycline. This patient had severe hypereosinophilia and massively increased IgE levels. Experimental studies in this case revealed elevated IFN-γ-, as well as TNF-α-producing CD4+ and CD8+ T-cells after in vitro stimulation with minocycline, indicating a type I/IgE-mediated as well as type II/cytotoxic reaction in the pathogenesis of minocycline-induced liver failure. Although mild forms of liver involvement are well known side effects of minocycline, only 8 cases with acute liver failure have been reported, and we present a review of all cases., (© Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2012
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