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Early loss of primary teeth is an important problem in pediatric dentistry. One of the most difficult aspects during treatment of the complications of caries in primary teeth is the duration of treatment. The introduction of rotary nickel-titanium systems made endodontic treatment in primary teeth easier and faster. Thereby, the aim of the present work was to conduct a systematic review with elements of the network meta-analysis and an indirect comparison of different rotary endodontic systems in terms of the time spent for endodontic treatment in primary tooth canals using the common comparator «manual treatment with K-files». Seven articles were included in the final analysis, which revealed statistically significant heterogeneity of the included data from laboratory randomized controlled trials (ProTaper/K-file: I2 = 85; p = 0.00001 and Mtwo/K-file: I2 = 95; p = 0.00001). A systematic review of the articles revealed a trend toward designating the Mtwo (VDW) system as the least time-consuming mechanical root canal preparation in primary teeth.

The search for new, fast and non-invasive methods of diagnosing diseases of both the oral cavity and general diseases of various etiologies and their introduction into practical health care is still a priority in the field of medicine. Among the known methods of analysis of biological fluids, a special place is occupied by the study of saliva. Oral fluid analysis has a high potential in screening for various diseases, since it contains a wide range of organic and inorganic compounds. A significant number of works have been devoted to the study of the quantitative and qualitative composition of the oral fluid, as well as to the study of saliva biomarkers, however, the study of the saliva proteome is at the stage of data accumulation. The lack of standardization in the collection of samples and methods of analysis, as well as poorly studied physiological and biochemical parameters of the oral fluid, hinders the introduction of advances in the study of the saliva proteome into diagnostic practice. The solution of these problems will allow the oral fluid to be used as a biological environment for both detecting diseases and predicting their course.

The introduction of modified bioceramic calcium silicate- based materials into clinical practice has changed the standards and strategies of endodontic treatment. The review article highlights modern calcium silicate- based cements that are used in various areas of endodontics, including vital pulp therapy, root canal obturation, management of endodontic complications and pulp regeneration. The classifications of bioceramic materials based on their chemistry and specific use in endodontics are presented. The physicochemical and biological properties of various types of materials, as well as the features of their clinical application, are described.

A new stage of development has molecular and biological diagnostics of pulp diseases In the tield of modern dentistry. Recent studies Indicate that molecules expressed at different stages of the In'flammatory process can serve as diagnostic blomarkers of pulp diseases. The review article presents relevant sclentfTc data regarding In^ammatlon markers In various pulp pathologies. Including Initial pulpitis.