1. Bioactive Secondary Metabolites from Vincetoxicum stocksii.
- Author
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Tousif, Muhammad Imran, Shazmeen, Natasha, Riaz, Naheed, Hussain, Hidayat, Al-Harrasi, Ahmed, Yaqoob, Asma, Nasim, Faiz-ul-Hassan, Jabbar, Abdul, Khatoon, Tasneem, Tareen, Rasool Bakhsh, and Saleem, Muhammad
- Subjects
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PLANT metabolites , *APOCYNACEAE , *GLUCOPYRANOSIDE , *ANTIOXIDANTS , *NUCLEAR magnetic resonance spectroscopy , *CHEMICAL structure - Abstract
The ethyl acetate soluble fraction of the methanolic extract of Vincetoxicum stocksii yielded four new compounds; vincetolate (1), vincetoside (2), vincetetrol (3) and vincetomine (4) along with seven know compounds; 1-(4-hydroxy-3-methoxyphenyl)-1,2,3,-propanetriol (5), feruloyl-6-O-β-D-glucopyranoside (6), apocynin (7), 4-hydroxy-3,5-dimethoxybenzoic acid (8), 7- megastigmene-3,5,6,9-tetrol (9), qurcetin-3-O-β-D-glucopyranoside (10) and 4'- methoxykaempferol-3-O- β-D-glucopyranoside (11). The chemical structures of all the isolates were determined due to spectral analysis including sophisticated 1D- and 2D-NMR techniques and high resolution FABMS. Compounds 5-8 and 10 exhibited moderate to low antioxidant activity with IC50 values of 56.42±0.04-150±0.5 µg/ml whereas, compounds 1, 5 and 8-11 showed significant antiurease activity with IC50 values in the range of 22.1±0.43-105.47 ± 0.01µg/ml. [ABSTRACT FROM AUTHOR]
- Published
- 2016