1. Lymphovascular Invasion and HER2/neuAmplification as Predictive Factors for Axillary Lymph Node Metastasis in Early Breast Cancer Patients
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Young Duk Kim, Sung Jin Park, Sehwan Han, Eunah Shin, Hong-Yong Kim, Keun Ho Yang, Byung Noe Bae, Hong Ju Kim, Kyeongmee Park, Geumhee Gwak, Seung Woo Lim, Ji Young Kim, and Ki Whan Kim
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Univariate analysis ,biology ,business.industry ,medicine.drug_class ,Lymphovascular invasion ,Incidence (epidemiology) ,Lymph node metastasis ,Progesterone Receptor Status ,medicine.disease ,HER2/neu ,Breast cancer ,Estrogen ,Internal medicine ,medicine ,biology.protein ,business - Abstract
Purpose: Axillary lymph node metastasis (ALNM) can occur even in breast cancer smaller than 2 cm in size. This study was performed to investigate the clinicopathologic factors that affect node metastasis in T1 breast cancer. Methods: We reviewed the medical record of 206 T1 breast cancer patients and we divided them into two groups according to the presence or absence of lymph node metastasis. We analyzed the association between ALNM and various clinicopathological predictive factors such as age, tumor size (T1a, T1b, T1c), multiplicity, the histologic grade, the nuclear grade, the presence of lymphovascular invasion (LVI), the estrogen and progesterone receptor status, an HER2/neu expression, the Ki-67 labeling index and the bcl-2 expression. Results: One hundred and thirty-nine were the node negative group (T1N0) and the remaining 67 cases were allotted to the node positive group (T1N1-3). On the univariate analysis, age (p= 0.011), LVI (p
- Published
- 2010
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