1. Intensity-Modulated Radiotherapy versus Three-Dimensional Conformal Radiotherapy in Definitive Chemoradiotherapy for Cervical Esophageal Squamous Cell Carcinoma: Comparison of Survival Outcomes and Toxicities
- Author
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NaiBin Chen, JinYu Guo, Jun Zhang, Qiwen Li, Meng-Yun Qiang, Mengzhong Liu, Qun Li, Yonghong Hu, Bin Wang, Shao-Min Huang, Yujia Zhu, Bo Qiu, Ling-Zhi Cai, and Hui Liu
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Adult ,Male ,0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Survival ,Intensity-modulated radiotherapy ,medicine.medical_treatment ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,medicine ,Humans ,Fisher's exact test ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Conformal radiotherapy ,Proportional hazards model ,business.industry ,Cervical esophageal squamous cell carcinoma ,Hazard ratio ,Induction chemotherapy ,Radiotherapy Dosage ,Chemoradiotherapy ,Middle Aged ,Prognosis ,medicine.disease ,Combined Modality Therapy ,Survival Analysis ,Radiation therapy ,Regimen ,Treatment Outcome ,Tracheostomy dependence ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Esophageal stricture ,symbols ,Female ,Original Article ,Esophageal Squamous Cell Carcinoma ,Radiotherapy, Intensity-Modulated ,Radiology ,Radiotherapy, Conformal ,business ,Esophagitis - Abstract
Purpose The purpose of this study was to compare the survival and toxicities in cervical esophageal squamous cell carcinoma (CESCC) treated by concurrent chemoradiothrapy with either three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) techniques. Materials and methods A total of 112 consecutive CESCC patients were retrospectively reviewed. 3D-CRT and IMRT groups had been analyzed by propensity score matching method, with sex, age, Karnofsky performance status, induction chemotherapy, and tumor stage well matched. The Kaplan-Meier method and Cox proportional hazards model were used for overall survival (OS) and progression-free survival (PFS). Toxicities were compared between two groups by Fisher exact test. Results With a median follow-up time of 34.9 months, the 3-year OS (p=0.927) and PFS (p=0.859) rate was 49.6% and 45.8% in 3D-CRT group, compared with 54.4% and 42.8% in IMRT group. The rates of grade ≥ 3 esophagitis, grade ≥ 2 pneumonitis, esophageal stricture, and hemorrhage were comparable between two groups, while the rate of tracheostomy dependence was much higher in IMRT group than 3D-CRT group (14.3% vs.1.8%, p=0.032). Radiotherapy technique (hazard ratio [HR], 0.09; 95% confidence interval [CI], 0.01 to 0.79) and pretreatment hoarseness (HR, 0.12; 95% CI 0.02 to 0.70) were independently prognostic of tracheostomy dependence. Conclusion No survival benefits had been observed while comparing IMRT versus 3D-CRT in CESCC patients. IMRT with fraction dose escalation and pretreatment hoarseness were considered to be associated with a higher risk for tracheostomy dependence. Radiation dose escalation beyond 60 Gy should be taken into account carefully when using IMRT with hypofractionated regimen.
- Published
- 2020
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