1. Microwave-accelerated Solvent and Catalyst Free Synthesis of 3-Indolylhydroquinones
- Author
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T. Swamy, K. Premalatha, Jhillu S. Yadav, K. Shiva Shankar, and B. V. Subba Reddy
- Subjects
biology ,Chemistry ,Asterriquinone ,Biological activity ,General Chemistry ,Cell cycle ,biology.organism_classification ,Combinatorial chemistry ,Reverse transcriptase ,Catalysis ,Solvent ,medicine.anatomical_structure ,medicine ,Aspergillus terreus ,Nucleus - Abstract
The 3-indolylbenzoquinone nucleus is present in various biologically active natural products such as asterriquinones. 1 The asterriquinones and demethylasterriquinones (Figure 1) have recently been isolated from a wide range of fungi, including Aspergillus terreus, Chaetomium sp. and Pseudomassaria sp. 2 They exhibit a wide spectrum of biological activities including antitumor properties and are inhibitors of HIV reverse transcriptase. 3 Asterriquinone A1 has been shown to arrest the cell cycle in G1 and promote apoptotic cell death. 4 Recently, asterriquinone has also been reported
- Published
- 2008
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