1. IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma.
- Author
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Zaydfudim, Victor M., Wang, Andrew Y., de Lange, Eduard E., Zhao, Zimin, Moskaluk, Christopher A., Bauer, Todd W., and Adams, Reid B.
- Subjects
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CHOLANGITIS , *CHOLANGIOCARCINOMA , *SERUM , *BILE ducts , *AUTOIMMUNE diseases - Abstract
IgG4-associated cholangitis can mimic hilar cholangiocarcinoma. Previously reported patients with IgG4-associated cholangitis mimicking cholangiocarcinoma had elevated serum IgG4 levels and long-segment biliary strictures. However, in the absence of other diagnostic criteria for malignancy, IgG4-associated cholangitis should remain a consideration among patients with normal serum IgG4 and a hilar mass suspicious for cholangiocarcinoma. The presence of a hilar mass and a malignant-appearing biliary stricture in two patients with normal serum IgG4 prompted further evaluation and subsequent concomitant liver and bile duct resection and reconstruction. The diagnosis of IgG4-associated cholangitis was established during the pathologic evaluation of the resected specimens. IgG4-associated cholangitis is a known imitator of hilar cholangiocarcinoma and should be considered in the differential diagnosis even among serologically IgG4-negative patients with a hilar mass prior to operative resection. [ABSTRACT FROM AUTHOR] more...
- Published
- 2015
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