1. Tissue Clock Beyond Time Clock: Endovascular Thrombectomy for Patients With Large Vessel Occlusion Stroke Beyond 24 Hours
- Author
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Ghada A. Mohamed, Raul G. Nogueira, Muhammed Amir Essibayi, Hassan Aboul-Nour, Mahmoud Mohammaden, Diogo C. Haussen, Aldo Mendez Ruiz, Bradley A. Gross, Okkes Kuybu, Mohamed M. Salem, Jan-Karl Burkhardt, Brian Jankowitz, James E. Siegler, Pratit Patel, Taryn Hester, Santiago Ortega-Gutierrez, Mudassir Farooqui, Milagros Galecio-Castillo, Thanh N. Nguyen, Mohamad Abdalkader, Piers Klein, Jude H. Charles, Vasu Saini, Dileep R. Yavagal, Ammar Jumah, Ali Alaraj, Sophia Peng, Muhammad Hafeez, Omar Tanweer, Peter Kan, Jacopo Scaggiante, Stavros Matsoukas, Johanna T. Fifi, Stephan A. Mayer, and Alex B. Chebl
- Subjects
thrombectomy ,ischemic stroke ,delayed treatment ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background and Purpose Randomized trials proved the benefits of mechanical thrombectomy (MT) for select patients with large vessel occlusion (LVO) within 24 hours of last-known-well (LKW). Recent data suggest that LVO patients may benefit from MT beyond 24 hours. This study reports the safety and outcomes of MT beyond 24 hours of LKW compared to standard medical therapy (SMT). Methods This is a retrospective analysis of LVO patients presented to 11 comprehensive stroke centers in the United States beyond 24 hours from LKW between January 2015 and December 2021. We assessed 90-day outcomes using the modified Rankin Scale (mRS). Results Of 334 patients presented with LVO beyond 24 hours, 64% received MT and 36% received SMT only. Patients who received MT were older (67±15 vs. 64±15 years, P=0.047) and had a higher baseline National Institutes of Health Stroke Scale (NIHSS; 16±7 vs.10±9, P
- Published
- 2023
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