1. Frequency of PAR4 Ala120Thr variant associated with platelet reactivity significantly varies across sub-Saharan African populations
- Author
-
Abdimajid Osman, Menikae Kanchena Heenkenda, and Tomas L. Lindahl
- Subjects
0301 basic medicine ,Blood Platelets ,Sub saharan ,Genotype ,Somalia ,Immunology ,Black People ,030204 cardiovascular system & hematology ,Biology ,Biochemistry ,Polymorphism, Single Nucleotide ,Platelet reactivity ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Gene Frequency ,Humans ,Point Mutation ,Platelet ,Letter to Blood ,Africa South of the Sahara ,business.industry ,Klinisk medicin ,Cell Biology ,Hematology ,Platelet Activation ,030104 developmental biology ,Receptors, Thrombin ,Clinical Medicine ,business ,BLOOD Commentary - Abstract
The concept of race based on physical appearance, social grouping, or self-identification has been challenged for decades. With the recent sequencing of thousands of human genomes, this concept has been further redefined. In this issue of Blood, Heenkenda et al show that the A allele frequency of the F2RL3 rs773902 A/G dimorphism associated with increased platelet reactivity is significantly lower in Somalians than what has been previously described for blacks in the United States, underscoring the importance of genetics and geographic ancestry for determining disease risk.1
- Published
- 2018