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Atrial natriuretic peptide can increase glomerular filtration rate and filtration fraction and can promote natriuresis, effects that would logically seem to improve renal function after acute tubular necrosis from ischemic or toxic injury. Early human trials suggested a beneficial effect of atrial natriuretic peptide on creatinine clearance, and a reduction in the need for dialysis in treated patients. However, randomized, placebo-controlled trials have failed to show a clinically relevant benefit on survival, dialysis-free survival, or renal function in patients treated with this agent.

We have used GMA-embedded tissues sectioned 2-3 mu for the identification of granulated cells in wounded and normal macaque tissues. Mast cell granules stain brilliantly with Giemsa or with PAS counterstained with alcian blue, neutrophils stand out clearly when treated with the PAS method and macrophage granules stain with PAS as well as with basic dyes. These techniques are helpful for the identification of these cells during wound healing and during inflammatory processes.