1. Microbial Diversity and Community Structures Among Those With Moderate to Severe TBI: A United States-Veteran Microbiome Project Study.
- Author
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Brenner, Lisa A., Stamper, Christopher E., Hoisington, Andrew J., Stearns-Yoder, Kelly A., Stanislawksi, Maggie A., Brostow, Diana P., Hoffmire, Claire A., Forster, Jeri E., Schneider, Alexandra L., Postolache, Teodor T., and Lowry, Christopher A.
- Abstract
Objective: To evaluate the association between distal moderate/severe traumatic brain injury (TBI) history and the human gut microbiome. Setting: Veterans Affairs Medical Center. Participants: Veterans from the United States-Veteran Microbiome Project (US-VMP). Veterans with moderate/severe TBI (n = 34) were compared with (1) Veterans with a history of no TBI (n = 79) and (2) Veterans with a history of no TBI or mild TBI only (n = 297). Design: Microbiome analyses from 16S rRNA gene sequencing with gut microbiota function inferred using PICRUSt2. Main Measures: α-Diversity and β-diversity of the gut microbiome, as well as taxonomic and functional signatures associated with moderate/severe TBI. Results: There were no significant differences in gut bacterial α- and β-diversity associated with moderate/severe TBI status. No differentially abundant taxa were identified when comparing samples from moderate/severe TBI to those with no TBI or no TBI/mild TBI. Conclusion: Results suggest that moderate/severe TBI-related changes to the gut microbiome do not persist for years postinjury. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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