9 results on '"Buus NH"'
Search Results
2. Disproportionally impaired microvascular structure in essential hypertension.
- Author
-
Eftekhari A, Mathiassen ON, Buus NH, Gotzsche O, Mulvany MJ, Christensen KL, Eftekhari, Ashkan, Mathiassen, Ole Norling, Buus, Niels Henrik, Gotzsche, Ole, Mulvany, Michael John, and Christensen, Kent Lodberg
- Published
- 2011
- Full Text
- View/download PDF
3. Small artery stucture adapts to vasodilatation rather than to blood pressure during antihypertensive treatment.
- Author
-
Mathiassen ON, Buus NH, Larsen ML, Mulvany MJ, and Christensen KL
- Published
- 2007
- Full Text
- View/download PDF
4. Small artery structure is an independent predictor of cardiovascular events in essential hypertension.
- Author
-
Mathiassen ON, Buus NH, Sihm I, Thybo NK, Mørn B, Schroeder AP, Thygesen K, Aalkjaer C, Lederballe O, Mulvany MJ, and Christensen KL
- Published
- 2007
- Full Text
- View/download PDF
5. Prediction of Renal Function in Living Kidney Donors and Recipients of Living Donor Kidneys Using Quantitative Histology.
- Author
-
Buus NH, Nielsen CM, Skov K, Ibsen L, Krag S, and Nyengaard JR
- Subjects
- Humans, Adult, Middle Aged, Living Donors, Kidney physiology, Glomerular Filtration Rate, Fibrosis, Kidney Transplantation adverse effects, Kidney Transplantation methods, Renal Insufficiency, Chronic
- Abstract
Background: Living kidney donors (LKDs) are at increased risk of chronic kidney disease, whereas transplant recipients experience progressive reduction of graft function. We examined the predictive value of quantitative stereology on renal function in LKDs and recipients of living donor kidneys, based on perioperative biopsies from the donated kidney., Methods: Cortex volume of both donor kidneys was determined by contrast-enhanced computed tomography and single-kidney glomerular filtration rate (GFR) by 51 chrome-EDTA clearance together with renography. Glomerular density was used to estimate total glomeruli number in addition to glomerular volume, glomerular sclerosis, kidney fibrosis, and arteriole dimensions. GFR measurements were repeated 1 y after transplantation in both LKDs and recipients. Associations between GFR at follow-up and cortex volume and histomorphometric parameters after adjustment of age, gender, body mass index, smoking status, 24-h blood pressure, and single-kidney GFR were examined., Results: We included 49 LKDs (age, 51 ± 12 y) and 51 recipients (age, 44 ± 13 y). At follow-up, GFR was 71 ± 16 mL/min in LKDs and 61 ± 18 mL/min in recipients with hyperfiltration being more prominent in LKDs (30.4%) as compared to recipients (16.4%; P < 0.05). One-year GFR in donors correlated to cortex volume ( P < 0.001) but not to any histological parameters, whereas GFR in recipients correlated to the amount of interstitial fibrosis ( P < 0.01) but not to other histological parameters or cortex volume., Conclusions: Kidney cortex volume, but not renal histology parameters, predicts 1-y renal outcome in LKDs. In contrast, the amount of interstitial fibrosis, but not cortex volume, predicts 1-y graft function in recipients., Competing Interests: The authors declare no conflicts of interest. The results presented in this article have not been previously published in whole, but data examples from a few individuals have been presented in a methodological article (Nielsen CM, Skov K, Buus NH, et al. Kidney structural characteristics based on a kidney biopsy and contrast-enhanced computed tomography in healthy living kidney donors. Anat Rec (Hoboken ). 2020;303:2693–2701)., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
6. Comparison of self- and nurse-measured office blood pressure in patients with chronic kidney disease.
- Author
-
Tougaard BG, Laursen KS, Jensen JD, and Buus NH
- Subjects
- Blood Pressure, Blood Pressure Determination, Humans, Hypertension diagnosis, Middle Aged, Patients, Nurses, Renal Insufficiency, Chronic
- Abstract
Objective: As blood pressure (BP) control is very important in chronic kidney disease (CKD), we investigated how office BP is influenced by the measurement circumstances and compared nonautomated self- and nurse-measured BP values., Materials and Methods: Two hundred stage 1-5 CKD patients with scheduled visits to an outpatient clinic were randomized to either self-measured office BP (SMOBP) followed by nurse-measured office BP (NMOBP) or NMOBP followed by SMOBP. The participants had been educated to perform the self-measurement in at least one previous visit. The SMOBP and NMOBP measurement series both consisted of three recordings, and the means of the last two recordings during SMOBP and NMOBP were compared for the 174 (mean age 52.5 years) with complete BP data., Results: SMOBP and NMOBP showed similar systolic (135.3 ± 16.6 vs 136.4 ± 17.4 mmHg, Δ = 1.1 mmHg, P = 0.13) and diastolic (81.5 ± 10.2 vs 82.2 ± 10.4 mmHg, Δ = 0.6 mmHg, P = 0.09) values. The change in BP from the first to the third recording was not different for SMOBP and NMOBP. In 17 patients, systolic SMOBP was ≥10 mmHg higher than NMOBP and in 28 patients systolic NMOBP exceeded SMOBP by ≥10 mmHg. The difference between systolic SMOBP and NMOBP was independent of CKD stage and the number of medications, but significantly more pronounced in patients above 60 years., Conclusion: In a population of CKD patients, there is no clinically relevant difference in SMOBP and NMOBP when recorded at the same visit. However, in 25% of the patients, systolic BP differs ≥10 mmHg between the two measurement modalities.
- Published
- 2020
- Full Text
- View/download PDF
7. Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia.
- Author
-
Buus NH, Bøttcher M, Hermansen F, Sander M, Nielsen TT, and Mulvany MJ
- Subjects
- Adult, Arginine pharmacology, Blood Pressure drug effects, Coronary Circulation drug effects, Coronary Circulation physiology, Coronary Vessels diagnostic imaging, Coronary Vessels drug effects, Coronary Vessels physiology, Endothelium, Vascular drug effects, Endothelium, Vascular metabolism, Enzyme Inhibitors pharmacology, Heart physiology, Heart Rate drug effects, Humans, Hyperemia metabolism, Male, Microcirculation drug effects, Microcirculation physiology, Myocardium metabolism, NG-Nitroarginine Methyl Ester pharmacology, Nitric Oxide biosynthesis, Phentolamine pharmacology, Tomography, Emission-Computed, Vascular Resistance drug effects, Vasodilation drug effects, Adenosine pharmacology, Adrenergic alpha-Antagonists pharmacology, Heart drug effects, Hyperemia chemically induced, Nitric Oxide Synthase antagonists & inhibitors
- Abstract
Background: Myocardial perfusion during adenosine-induced hyperemia is used both in clinical diagnosis of coronary heart disease and for scientific investigations of the myocardial microcirculation. The objective of this study was to clarify whether adenosine-induced hyperemia is dependent on endothelial NO production or is influenced by adrenergic mechanisms., Methods and Results: In 12 healthy men, myocardial perfusion was measured with PET in 2 protocols performed in random order, each including 3 perfusion measurements. First, perfusion was measured at rest. Second, either saline or the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME, 4 mg/kg) was infused, and perfusion during adenosine-induced hyperemia was determined. Last, in both protocols, the alpha-receptor blocker phentolamine was infused, and perfusion during adenosine-induced hyperemia was determined again. Resting perfusion was similar in the 2 protocols (0.69+/-0.14 and 0.66+/-0.18 mL. min(-1). g(-1)). L-NAME increased mean arterial blood pressure by 12+/-7 mm Hg (P<0.01) and reduced heart rate by 16+/-7 bpm (P<0.01). Adenosine-induced hyperemia (1.90+/-0.33 mL. min(-1). g(-1)) was attenuated by L-NAME (1.50+/-0.55 mL. min(-1). g(-1), P<0.01). The addition of phentolamine had no effect on the adenosine-induced hyperemia (2.10+/-0.34 mL. min(-1). g(-1), P=NS). In the presence of L-NAME, however, when the adenosine response was attenuated, phentolamine was able to increase hyperemic perfusion (2.05+/-0.44 mL. min(-1). g(-1), P<0.05)., Conclusions: Inhibition of endogenous NO synthesis attenuates myocardial perfusion during adenosine-induced hyperemia, indicating that coronary vasodilation by adenosine is partly endothelium dependent. alpha-Adrenergic blockade has no effect on adenosine-induced hyperemia unless NO synthesis is inhibited.
- Published
- 2001
- Full Text
- View/download PDF
8. Peripheral flow response to transient arterial forearm occlusion does not reflect myocardial perfusion reserve.
- Author
-
Bøttcher M, Madsen MM, Refsgaard J, Buus NH, Dørup I, Nielsen TT, and Sørensen K
- Subjects
- Adult, Aged, Arterial Occlusive Diseases diagnostic imaging, Blood Pressure, Brachial Artery physiology, Female, Forearm, Humans, Male, Microcirculation, Middle Aged, Myocardial Ischemia physiopathology, Perfusion, Statistics as Topic, Ultrasonography, Vasodilation, Arterial Occlusive Diseases physiopathology
- Abstract
Background: Ultrasonographic evaluation of systemic arterial function is widely available, and a close relation of endothelial function in the coronary and brachial arteries has been documented. It is unknown, however, whether a similar correlation exists for their 2 microcirculatory territories and thus whether assessment of the systemic microcirculation can be used similarly as a surrogate marker of myocardial perfusion., Methods and Results: Twenty-three patients with documented coronary artery disease (CAD; 66+/-9 years old, 18 men), 16 patients with syndrome X (SX; 56+/-5 years old, 13 women), and 45 healthy control subjects (C; 34+/-9 years old, 22 men) were studied. Myocardial perfusion was measured at rest and after dipyridamole (0.56 mg. kg(-1). min(-1) over 4 minutes) by PET, and brachial artery blood flow was measured at rest and after transient forearm ischemia by standard Doppler ultrasound techniques. Dipyridamole increased myocardial perfusion in all groups (mL. g(-1). min(-1): CAD, 0.89+/-0.27 versus 1.62+/-0.67, P:<0.001; SX, 0.82+/-0.16 versus 1.67+/-0.49, P:<0.001; and C, 0.82+/-0.15 versus 2.32+/-0.64, P:<0.001). Postocclusion forearm flow increased similarly in all groups (CAD, 52+/-18 versus 174+/-77 mL/min, P:<0.001; SX, 49+/-29 versus 202+/-82 mL/min, P:<0.001; and C, 61+/-34 versus 229+/-108 mL/min, P:<0.001). No significant correlations were found between peripheral and myocardial microcirculatory beds for either resting flow, hyperemic flow, or flow reserve in any of the groups (r(2)<0.1, P:=NS)., Conclusions: The peripheral perfusion responses to transient forearm ischemia do not correlate with dipyridamole-induced myocardial hyperemia. The lack of correlation indicates different mechanisms of microvascular activation or regulation and confirms that extrapolations between findings in the 2 vascular beds are not suitable.
- Published
- 2001
- Full Text
- View/download PDF
9. Effect of short- and long-term heart failure on small artery morphology and endothelial function in the rat.
- Author
-
Buus NH, Kahr O, and Mulvany MJ
- Subjects
- Animals, Body Weight, Cardiac Output physiology, Coronary Vessels physiopathology, In Vitro Techniques, Infarction pathology, Ligation, Male, Organ Size, Rats, Rats, Wistar, Time Factors, Acetylcholine pharmacology, Endothelium, Vascular physiopathology, Heart Failure pathology, Heart Failure physiopathology, Hemodynamics physiology, Mesenteric Arteries pathology
- Abstract
Chronic heart failure (HF) is associated with hemodynamic changes and activation of several neurohormonal systems, which are able both to inhibit and to facilitate arterial growth or remodeling and also to influence endothelial function. As these vascular changes may depend on the duration of HF, we evaluated morphologic and endothelial functional alterations in a rat model of HF after a short and long duration of HF. Rats with coronary ligation and sham-operated controls were investigated either 8 or 26 weeks after the operation with measurements of hemodynamics and isolated mesenteric small artery morphology and endothelial function. The effect of HF and duration of HF were examined by using two-way analysis of variance (ANOVA). HF rats had altered hemodynamics with reductions in cardiac output, left ventricular systolic pressure, and mean blood pressure, whereas left ventricular diastolic pressure was increased. HF caused remodeling of anatomically well-defined mesenteric small arteries with a reduction in media thickness and media-to-lumen ratio, but without change in the media cross-sectional area. Neither HF nor time had any influence on sensitivity or maximal relaxation to acetylcholine in the presence of indomethacin, but HF reduced vasoconstriction due to nitric oxide synthase blockade with N(G)-nitro-L-arginine independent of time. Our results indicate that HF, induced by coronary ligation in the rat, has a remodeling effect on mesenteric small arteries. However, the remodeling is moderate compared with that observed in hypertension. Furthermore, our results suggest that HF reduces basal release of NO.
- Published
- 1999
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.