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Start Over Author "Dever LL" Publisher lippincott williams & wilkins
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2. Impact of adding maraviroc to antiretroviral regimens in patients with full viral suppression but impaired CD4 recovery.

Author

Stepanyuk O, Chiang TS, Dever LL, Paez SL, Smith SM, Perez G, and Eng RH

Subjects
Aged, Antiretroviral Therapy, Highly Active methods, CD4 Lymphocyte Count, Drug Evaluation, Endotoxins blood, HIV Infections immunology, HIV Infections virology, Humans, Male, Maraviroc, Middle Aged, RNA, Viral blood, Retrospective Studies, Treatment Outcome, Cyclohexanes therapeutic use, HIV Fusion Inhibitors therapeutic use, HIV Infections drug therapy, HIV-1 isolation & purification, Triazoles therapeutic use
Abstract

We reviewed the effect of adding maraviroc on CD4 cell counts in nine patients on antiretroviral therapy with full viral suppression but impaired CD4 cell recovery. There were no significant differences in changes in CD4 cell count, percentage of CD4 cells, or in the ratio of CD4/CD8 cells at 30 days and 25 weeks of maraviroc therapy. Plasma endotoxin levels measured in four patients before and during maraviroc treatment also showed no significant differences.

Published
2009
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