1. Advances in Vascular Hyporeactivity After Shock: The Mechanisms and Managements.
- Author
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Duan C, Yang G, Li T, and Liu L
- Subjects
- Acidosis, Adult, Age Factors, Aged, Analgesics, Opioid chemistry, Blood Vessels drug effects, Burns therapy, Calcium chemistry, Carbon Monoxide chemistry, Cell Membrane metabolism, Critical Illness, Endothelins chemistry, Female, Humans, Male, Middle Aged, Nitric Oxide chemistry, Peptides chemistry, Protein Kinase C chemistry, Sex Factors, Shock, Septic therapy, Tetradecanoylphorbol Acetate chemistry, rho-Associated Kinases metabolism, Blood Vessels physiopathology, Shock, Hemorrhagic physiopathology, Shock, Hemorrhagic therapy, Vasoconstrictor Agents therapeutic use, Vasodilator Agents therapeutic use
- Abstract
Vascular reactivity to vasoconstrictors and vasodilators is greatly reduced after severe trauma, shock, and sepsis or multiple organ dysfunction syndrome. This reduced vascular reactivity severely interferes with the treatment of shock and other critical conditions. In particular, it interferes with the efficacy of vasoactive agents. Consequently, it is very important to elucidate the mechanisms and search for the effective treatment measures. In recent years, a lot of studies focused on the characteristics and the change rules of vascular hyporeactivity and mechanisms following shock. Also, the treatment approaches based on various mechanisms have been a hot pot these years.
- Published
- 2015
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