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Your search keyword '"Gallardo, David"' showing total 6 results
Start Over Author "Gallardo, David" Publisher lippincott williams & wilkins
6 results on '"Gallardo, David"'

6. Hla-DPB1 mismatch in HLA-A-B-DRB1 identical sibling donor stem cell transplantation and acute graft-versus-host disease.

Author

Gallardo D, Brunet S, Torres A, Alonso-Nieto M, Vallejo C, Jiménez A, González M, Sanz G, Serrano D, Espigado I, Osorio S, Carreras E, Martiín C, Sanz-Rodríguez C, Sierra J, Zuazu J, González-Escribano MF, González JR, Román J, De Oteyza JP, and De La Cámara R

Subjects
Acute Disease, Adolescent, Adult, Aged, Female, HLA-DP beta-Chains, HLA-DRB1 Chains, Humans, Male, Middle Aged, Retrospective Studies, Tissue Donors, Graft vs Host Disease etiology, HLA-A Antigens immunology, HLA-B Antigens immunology, HLA-DP Antigens immunology, HLA-DR Antigens immunology, Histocompatibility Testing, Stem Cell Transplantation adverse effects
Abstract

Background: The role of human leukocyte antigen (HLA)-DPB1 as a transplantation antigen is controversial. A higher incidence of acute graft-versus-host disease (aGVHD) has been described after unrelated donor bone marrow transplant when both HLA-DPB1 alleles were mismatched., Methods: We investigated the impact of a single HLA-DPB1 mismatch after HLA-A-B-DRB1 identical sibling donor transplantation on aGVHD. We analyzed 627 adult patient-donor pairs and identified 30 pairs without HLA-DPB1 identity (4.78%). In 17 cases, the patient had an allele that was not shared by the donor., Results: The cumulative incidence of grades II-IV aGVHD was higher in the HLA-DPB1 mismatched group (66.7% vs. 35.7%, p=0.012). The HLA-DPB1 mismatch was identified by multivariate analysis as an independent risk factor for aGVHD (p=0.020, RR=2.68, 95% CI: 1.73-3.62)., Conclusions: HLA-DPB1 can mediate alloreactive responses. A single HLA-DPB1 mismatch increases the risk of aGVHD after sibling donor stem cell transplantation.

Published
2004
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