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Your search keyword '"Garzoni, Christian"' showing total 6 results
Start Over Author "Garzoni, Christian" Publisher lippincott williams & wilkins
6 results on '"Garzoni, Christian"'

2. Protection from varicella zoster in solid organ transplant recipients carrying killer cell immunoglobulin-like receptor B haplotypes

Author

Schmied, Laurent, Terszowski, Grzegorz, Gonzalez, Asensio, Schmitter, Karin, Hirsch, Hans H, Garzoni, Christian, van Delden, Christian, Boggian, Katia, Mueller, Nicolas J, Berger, Christoph; https://orcid.org/0000-0002-2373-8804, Villard, Jean, Manuel, Oriol, Meylan, Pascal, Hess, Christoph, Stern, Martin, Schmied, Laurent, Terszowski, Grzegorz, Gonzalez, Asensio, Schmitter, Karin, Hirsch, Hans H, Garzoni, Christian, van Delden, Christian, Boggian, Katia, Mueller, Nicolas J, Berger, Christoph; https://orcid.org/0000-0002-2373-8804, Villard, Jean, Manuel, Oriol, Meylan, Pascal, Hess, Christoph, and Stern, Martin

Abstract

BACKGROUND: Natural killer cell function is regulated by inhibitory and activating killer cell immunoglobulin-like receptors (KIR). Previous studies have documented associations of KIR genotype with the risk of cytomegalovirus (CMV) replication after solid organ transplantation. METHODS: In this study of 649 solid organ transplant recipients, followed prospectively for infectious disease events within the Swiss Transplant Cohort Study, we were interested to see if KIR genotype associated with virus infections other than CMV. RESULT: We found that KIR B haplotypes (which have previously been linked to protection from CMV replication) were associated with protection from varicella zoster virus infection (hazard ratio, 0.43; 95% confidence interval, 0.21-0.91; P = 0.03). No significant associations were detected regarding the risk of herpes simplex, Epstein-Barr virus or BK polyomavirus infections. CONCLUSIONS: In conclusion, these data provide evidence that the relative protection of KIR haplotype B from viral replication after solid organ transplantation may extend beyond CMV to other herpes viruses, such as varicella zoster virus and possibly Epstein-Barr virus.

Published
2015

5. Viral Suppression Rates in Salvage Treatment With Raltegravir Improved With the Administration of Genotypic Partially Active or Inactive Nucleoside/Tide Reverse Transcriptase Inhibitors.

Author

Scherrer, Alexandra U, Wyl, Viktor von, Böni, Jürg, Yerly, Sabine, Klimkait, Thomas, Bürgisser, Philippe, Garzoni, Christian, Hirschel, Bernard, Cavassini, Matthias, Battegay, Manuel, Vernazza, Pietro L, Bernasconi, Enos, Ledergerber, Bruno, and Günthard, Huldrych F

Published
2011
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6. Protection From Varicella Zoster in Solid Organ Transplant Recipients Carrying Killer Cell Immunoglobulin-Like Receptor B Haplotypes.

Author

Schmied L, Terszowski G, Gonzalez A, Schmitter K, Hirsch HH, Garzoni C, van Delden C, Boggian K, Mueller NJ, Berger C, Villard J, Manuel O, Meylan P, Hess C, and Stern M

Subjects
Adolescent, Adult, Aged, Chickenpox virology, Child, Child, Preschool, Female, Follow-Up Studies, Graft Rejection immunology, Graft Rejection prevention & control, Haplotypes, Humans, Infant, Infant, Newborn, Male, Middle Aged, Retrospective Studies, Young Adult, Chickenpox prevention & control, Herpesvirus 3, Human genetics, Kidney Transplantation, Receptors, KIR genetics, Transplant Recipients, Virus Replication genetics
Abstract

Background: Natural killer cell function is regulated by inhibitory and activating killer cell immunoglobulin-like receptors (KIR). Previous studies have documented associations of KIR genotype with the risk of cytomegalovirus (CMV) replication after solid organ transplantation., Methods: In this study of 649 solid organ transplant recipients, followed prospectively for infectious disease events within the Swiss Transplant Cohort Study, we were interested to see if KIR genotype associated with virus infections other than CMV., Result: We found that KIR B haplotypes (which have previously been linked to protection from CMV replication) were associated with protection from varicella zoster virus infection (hazard ratio, 0.43; 95% confidence interval, 0.21-0.91; P = 0.03). No significant associations were detected regarding the risk of herpes simplex, Epstein-Barr virus or BK polyomavirus infections., Conclusions: In conclusion, these data provide evidence that the relative protection of KIR haplotype B from viral replication after solid organ transplantation may extend beyond CMV to other herpes viruses, such as varicella zoster virus and possibly Epstein-Barr virus.

Published
2015
Full Text
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