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Hypothalamic pro-opiomelanocortin (POMC) neurons are key sensory neurons for energy balance. The basic helix-loop helix transcription factor, NHLH2 is expressed in POMC neurons, and Nhlh2 knockout mice show adult-onset obesity with low exercise behavior. Evidence is presented to explore the hypothesis that NHLH2 transcriptional activity within POMC neurons is crucial for maintaining motivated spontaneous activity and enforced exercise. [ABSTRACT FROM AUTHOR]

The article proposes using exercise to improve muscle strength of individuals with Duchenne Muscular Dystrophy (DMD). It discusses the nature and characteristics of DMD. The authors state that the absence of systematic analysis to determine the functional capabilities of the diseased muscle is a major limitation to the use of exercise to treat neuromuscular diseases, particularly DMD.

Hypothalamic pro-opiomelanocortin (POMC) neurons are key sensory neurons for energy balance. The basic helix-loop-helix transcription factor NHLH2 is expressed in POMC neurons, and Nhlh2 knockout mice show adult-onset obesity with low exercise behavior. Evidence is presented to explore the hypothesis that NHLH2 transcriptional activity within POMC neurons is crucial for maintaining motivated spontaneous activity and enforced exercise.