14 results on '"Hamilton, Thomas E."'
Search Results
2. Double Supercharged Jejunal Interposition for Late Salvage of Long-gap Esophageal Atresia.
- Author
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Ganske, Ingrid M., Firriolo, Joseph M., Nuzzi, Laura C., Ganor, Oren, Hamilton, Thomas E., Smithers, C. Jason, Jennings, Russell W., Upton III, Joseph, Labow, Brian I., and Taghinia, Amir H.
- Published
- 2018
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3. Clinical Outcome and Biological Predictors of Relapse After Nephrectomy Only for Very Low-risk Wilms Tumor.
- Author
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Fernandez, Conrad V., Perlman, Elizabeth J., Mullen, Elizabeth A., Yueh-Yun Chi, Hamilton, Thomas E., Gow, Kenneth W., Ferrer, Fernando A., Barnhart, Douglas C., Ehrlich, Peter F., Khanna, Geetika, Kalapurakal, John A., Bocking, Tina, Huff, Vicky, Jing Tian, Geller, James I., Grundy, Paul E., Anderson, James R., Dome, Jeffrey S., and Shamberger, Robert C.
- Abstract
Objective: To determine if observation alone after nephrectomy in very low-risk Wilms tumor (defined as stage I favorable histology Wilms tumors with nephrectomy weight <550g and age at diagnosis <2 years) results in satisfactory event-free survival and overall survival, and to correlate relapse with biomarkers. Patients and Methods: The AREN0532 study enrolled patients with very low-risk Wilms tumor confirmed by central review of pathology, diagnostic imaging, and surgical reports. After nephrectomy, patients were followed without adjuvant chemotherapy. Evaluable tumors were analyzed for WT1mutation, 1p and 16q copy loss, 1q copy gain, and 11p15 imprinting. The study was powered to detect a reduction in 4-year EFS from 87% to 75% and overall survival from 95% to 88%. Results: A total of 116 eligible patients enrolled with a median follow up of 80 months (range: 5–97 months). Twelve patients relapsed. Estimated 4-year event-free survival was 89.7% (95% confidence interval 84.1–95.2%) and overall survival was 100%. First sites of relapse were lung (n = 5), tumor bed (n = 4), and abdomen (n = 2), with one metachronous tumor in the contralateral kidney (n = 1) at a median time of 4.3 months for those who relapsed (range 2.3–44 months). The presence of intralobar (P = 0.46) or perilobar rests (P = 1.0) were not associated with relapse (P = 0.16). 1q gain, 1p and 16q loss, and WT1 mutation status were not associated with relapse. 11p15 methylation status was associated relapse (20% relapse with loss of heterozygosity, 25% with loss of imprinting, and 3.3% relapse with retention of the normal imprinting (P = 0.011)). Conclusions: Most patients meeting very low-risk criteria can be safely managed by nephrectomy alone with resultant reduced exposure to chemotherapy. Expansion of an observation alone strategy for low-risk Wilms tumor incorporating both clinical features and biomarkers should be considered. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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4. Regulatory oversight in transplantation.
- Author
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Hamilton, Thomas E.
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- 2013
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5. ESTIMATION OF THYROID RADIATION DOSES FOR THE HANFORD THYROID DISEASE STUDY: RESULTS AND IMPLICATIONS FOR STATISTICAL POWER OF THE EPIDEMIOLOGICAL ANALYSES.
- Author
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Kopecky, Kenneth J., Davis, Scott, Hamilton, Thomas E., Saporito, Mark S., and Onstad, Lynn E.
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IONIZING radiation dosage ,THYROID diseases ,HANFORD Site (Wash.) ,IODINE isotopes ,PHYSIOLOGICAL effects of radiation ,EPIDEMIOLOGY - Abstract
Residents of eastern Washington, northeastern Oregon, and western Idaho were exposed to
131 I released into the atmosphere from operations at the Hanford Nuclear Site from 1944 through 1972, especially in the late 1940's and early 1950's. This paper describes the estimated doses to the thyroid glands of the 3,440 evaluable participants in the Hanford Thyroid Disease Study, which investigated whether thyroid morbidity was increased in people exposed to radioactive iodine from Hartford during 1944-1957. The participants were born during 1940-1946 to mothers living in Benton, Franklin, Walla Walla, Adams, Okanogan, Ferry, or Stevens Counties in Washington State. Whenever possible someone with direct knowledge of the participant's early life (preferably the participant's mother) was interviewed about the participant's individual dose-determining characterisries (residence history, sources and quantifies of food, milk, and milk products consumed, production and processing techniques for home-grown food and milk products). Default information was used if no interview respondent was available. Thyroid doses were estimated using the computer program Calculation of Individual Doses from Environmental Radionuclides (CIDER) developed by the Hanford Environmental Dose Reconstruction Project. CIDER provided 100 sets of doses to represent uncertainty of the estimates. These sets were not generated independently for each participant, but reflected the effects of uncertainties in characteristics shared by participants. Estimated doses (medians of each participant's 100 realizations) ranged from 0.0029 mGy to 2823 mGy, with mean and median of 174 and 97 mGy, respectively. The distribution of estimated doses provided the Hanford Thyroid Disease Study with sufficient statistical power to test for dose-response relationships between thyroid outcomes and exposure to Hanford's131 I. [ABSTRACT FROM AUTHOR]- Published
- 2004
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6. Effect of Adenoviral Early Genes and the Host Immune System on In Vivo Pancreatic Gene Transfer in the Mouse.
- Author
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Mcclane, Steven J., Hamilton, Thomas E., Dematteo, Ronald P., Burke, Charlotte, and Raper, Steven E.
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- 1997
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7. Supercharged Jejunal Interposition: A Reliable Esophageal Replacement in Pediatric Patients.
- Author
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Firriolo, Joseph M., Nuzzi, Laura C., Ganske, Ingrid M., Hamilton, Thomas E., Smithers, C. Jason, Ganor, Oren, Upton III, Joseph, Taghinia, Amir H., Jennings, Russell W., and Labow, Brian I.
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- 2019
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8. Commentary on "Break the Rule of Three: Critical Thoughts from a Tertiary care Experience with Bougie Dilators".
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Yasuda JL, Ngo PD, Staffa SJ, Zendejas B, Hamilton TE, Jennings RW, and Manfredi MA
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- Child, Constriction, Pathologic, Dilatation, Humans, Tertiary Healthcare, Esophageal Stenosis
- Published
- 2021
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9. Rules Are Meant to Be Broken: Examining the "Rule of 3" for Esophageal Dilations in Pediatric Stricture Patients.
- Author
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Clark SJ, Staffa SJ, Ngo PD, Yasuda JL, Zendejas B, Hamilton TE, Jennings RW, and Manfredi MA
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- Adult, Child, Constriction, Pathologic, Dilatation, Humans, Prospective Studies, Retrospective Studies, Treatment Outcome, Esophageal Stenosis etiology, Esophageal Stenosis therapy
- Abstract
Background and Aims: The "rule of 3" is a 40-year-old expert opinion that suggests dilating an esophageal stricture more than 3 mm is unsafe. Few studies have evaluated this tenet, and do not specify how much larger than 3 mm is reasonable. Our aim was to determine the optimal point for maximum dilation diameter with acceptable risk in a pediatric population., Methods: A retrospective review in pediatric patients with esophageal strictures was performed. The number of millimeters the stricture was dilated, defined as delta dilation diameter (ΔDD), was determined by subtracting the initial stricture diameter from the diameter of the largest balloon used. Receiver operating characteristic curve analysis was used to evaluate the discriminatory ability of ΔDD. Youden J index was used to identify optimal cut-point in predicting perforation., Results: Two hundred eighty-four patients underwent 1384 balloon dilations. Overall perforation rate was 1.66%. There were 8 perforations in 1075 dilations with ΔDD ≤5 mm (0.7%) and 15 perforations in 309 dilations with ΔDD >5 mm (4.9%). Youden J index found an optimal cutoff to be at a ΔDD of ≤5 mm. The cumulative rate of perforation for all dilations ≤5 mm was 0.74% whereas the cumulative risk of perforation for all dilations ≥6 mm was 4.85% (P < 0.001)., Conclusions: Balloon dilations that expand the initial esophageal anastomosis ≤5 mm in a pediatric population appear to not unduly increase the risk of perforation. Further prospective studies are needed to further investigate the potential for a new rule of 5 for balloon dilation.
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- 2020
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10. Intralesional Steroid Injection Therapy for Esophageal Anastomotic Stricture Following Esophageal Atresia Repair.
- Author
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Ngo PD, Kamran A, Clark SJ, Jennings RW, Hamilton TE, Smithers CJ, Zendejas B, Yasuda JL, Zurakowski D, and Manfredi MA
- Subjects
- Constriction, Pathologic etiology, Constriction, Pathologic therapy, Humans, Postoperative Complications drug therapy, Retrospective Studies, Steroids, Treatment Outcome, Esophageal Atresia surgery, Esophageal Stenosis etiology, Esophageal Stenosis therapy
- Abstract
Objectives: The role of intralesional steroid injection (ISI) in the treatment of anastomotic stricture in patients with esophageal atresia remains unclear. The aim of this study was to evaluate the efficacy and safety of ISI., Methods: A total of 158 patients with esophageal atresia with at least 1 ISI for the treatment of esophageal anastomotic stricture between 2010 and 2017 were identified. The change in stricture diameter (ΔD) was compared between procedures with dilation alone (ISI-) and dilation with steroid injection (ISI+)., Results: A total of 1055 balloon dilations were performed (452 ISI+). The median ΔD was significantly greater in the ISI+ group: 1 mm (interquartile range [IQR] 0, 3) versus 0 mm (IQR -1, 1.5) (P < 0.0001). The ISI+ group had greater percentage of improved diameter (P < 0.0001) and lesser percentages of unchanged and decreased diameters at subsequent endoscopy (P = 0.0009, P = 0.003). Multivariable logistic regression confirmed the significance of ISI on increasing the likelihood of improved stricture diameter with an adjusted odds ratio of 3.24 (95% confidence interval: 2.15-4.88) (P < 0.001). The ΔD for the first 3 ISI+ procedures was greater than the ΔD for subsequent ISI+ procedures: 1 mm (IQR 0, 3) versus 0.5 mm (IQR-1.25, 2) (P = 0.001). There was no difference in perforation incidence between ISI+ and ISI- groups (P = 0.82)., Conclusions: ISI with dilation was well tolerated and improved anastomotic stricture diameter more than dilation alone. The benefit of ISI over dilation alone was limited to the first 3 ISI procedures.
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- 2020
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11. Esophagitis in Pediatric Esophageal Atresia: Acid May Not Always Be the Issue.
- Author
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Yasuda JL, Clark SJ, Staffa SJ, Blansky B, Ngo PD, Hamilton TE, Smithers CJ, Jennings R, and Manfredi MA
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- Child, Child, Preschool, Esophagitis, Peptic pathology, Esophagitis, Peptic surgery, Female, Fundoplication, Histamine H2 Antagonists administration & dosage, Humans, Infant, Male, Proton Pump Inhibitors administration & dosage, Esophageal Atresia, Esophagitis, Peptic drug therapy, Histamine H2 Antagonists therapeutic use, Proton Pump Inhibitors therapeutic use
- Abstract
Objective: Esophagitis is highly prevalent in patients with esophageal atresia (EA). Peptic esophagitis has long been assumed to be the primary cause of esophagitis in this population, and prolonged acid suppressive medication usage is common; such treatment is of unknown benefit and carries potential risk., Methods: To better understand the role of commonly used antireflux treatments in EA, we analyzed all patients with repaired EA who underwent endoscopy with biopsies at our institution between January 2016 and August 2018. Macroscopic erosive and histologic esophagitis on biopsy was graded per predefined criteria. Clinical characteristics including acid suppressive medication usage, type of EA and repair, presence of hiatal hernia, and history of fundoplication were reviewed., Results: There were 310 unique patients (33.5% long gap EA) who underwent 576 endoscopies with biopsies during the study period. Median age at endoscopy was 3.7 years (interquartile range 21-78 months). Erosive esophagitis was found in 8.7% of patients (6.1% of endoscopies); any degree of histologic eosinophilia (≥1 eosinophil/high power field [HPF]) was seen in 56.8% of patients (48.8% of endoscopies), with >15 eosinophils/HPF seen in 15.2% of patients (12.3% of endoscopies). Acid suppression was common; 86.9% of endoscopies were preceded by acid suppressive medication use. Fundoplication had been performed in 78 patients (25.2%). Proton pump inhibitor (PPI) and/or H2 receptor antagonist (H2RA) use were the only significant predictors of reduced odds for abnormal esophageal biopsy (P = 0.011 for PPI, P = 0.048 for H2RA, and P = 0.001 for PPI combined with H2RA therapy). However, change in intensity of acid suppressive therapy by either dosage or frequency was not significantly associated with change in macroscopic erosive or histologic esophagitis (P > 0.437 and P > 0.13, respectively). Presence or integrity of a fundoplication was not significantly associated with esophagitis (P = 0.236)., Conclusions: In EA patients, acid suppressive medication therapy is associated with reduced odds of abnormal esophageal biopsy, though histologic esophagitis is highly prevalent even with high rates of acid suppressive medication use. Esophagitis is likely multifactorial in EA patients, with peptic esophagitis as only one of multiple possible etiologies for esophageal inflammation. The clinical significance of histologic eosinophilia in this population warrants further investigation.
- Published
- 2019
- Full Text
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12. Endoscopic Esophageal Vacuum Therapy: A Novel Therapy for Esophageal Perforations in Pediatric Patients.
- Author
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Manfredi MA, Clark SJ, Staffa SJ, Ngo PD, Smithers CJ, Hamilton TE, and Jennings RW
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- Child, Preschool, Esophageal Perforation etiology, Esophagoscopy adverse effects, Esophagus surgery, Feasibility Studies, Female, Humans, Infant, Intraoperative Complications etiology, Male, Retrospective Studies, Stents, Treatment Outcome, Esophageal Atresia surgery, Esophageal Perforation surgery, Esophagoscopy methods, Intraoperative Complications surgery, Negative-Pressure Wound Therapy methods
- Abstract
Background: Esophageal perforation is a potentially life-threatening problem if not quickly diagnosed and treated appropriately. Negative-pressure wound therapy, commercially known as V.A.C. therapy, was developed in the early 1990s and is now standard of care for chronic surface wounds, ulcers, and burns. Adapting vacuum sponge therapy for use intraluminally for perforations of the esophagus was first reported in 2008. We report the first pediatric experience on a customized esophageal vacuum-assisted closure (EVAC) device for closure of esophageal perforations., Aim: To evaluate the technical feasibility, safety, and efficacy of EVAC in a pediatric population with esophageal perforations and compare efficacy to a cohort of patients who underwent stenting for esophageal perforation., Methods: We performed an institutional review board-approved retrospective chart review on all patients who underwent EVAC for esophageal perforations (October 2013-September 2017) and who underwent externally removable stent placement for esophageal perforation (January 2010-December 2017) at our institution. Our primary aim was to evaluate technical feasibility, efficacy, and safety in the treatment of pediatric esophageal perforations. A secondary aim was to compare the efficacy of EVAC to esophageal stenting in healing esophageal perforations in our pediatric population., Results: A total of 17 patients with esophageal atresia underwent therapy for esophageal perforation. Eight sponges were placed for surgical perforation and 9 were placed after endoscopic therapy perforation. The median age of patients was 24 months with the youngest patient being 3 months of age. The success rate of EVAC to seal all esophageal perforations was 88% (15/17). The success rate was similar in both subgroups: surgical anastomotic leaks at 88% (7/8) and endoscopic therapy leaks at 89% (8/9). There were no technical failures with placement. The stent group had a total of 24 patients: 19 were placed secondary to perforations from endoscopic therapy and 5 were placed secondary to surgical anastomotic perforations. The success rate of stents to seal all esophageal perforations was 63% (15/24). The success rate in the subgroups was 74% (14/19) for endoscopic therapy leaks and 20% (1/5) for surgical anastomotic leaks. In comparing success of EVAC and stent therapy, we found a statistically significant difference in favor of EVAC in healing surgical anastomotic perforations (P = 0.032). There was, however, no statistical difference in healing endoscopic therapy perforations (P = 0.360)., Conclusions: EVAC is a novel, promising technique for the treatment of esophageal perforations in a pediatric population. This treatment is comparable to esophageal stenting in iatrogenic endoscopic therapy perforations and superior to stenting surgical perforations. Further prospective studies are needed to compare the effectiveness of EVAC to esophageal stenting. Improvement in device design and customization could further improve success and ease of placement.
- Published
- 2018
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13. Endoscopic Electrocautery Incisional Therapy as a Treatment for Refractory Benign Pediatric Esophageal Strictures.
- Author
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Manfredi MA, Clark SJ, Medford S, Staffa SJ, Ngo PD, Hamilton TE, Smithers CJ, and Jennings RW
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- Child, Child, Preschool, Electrocoagulation adverse effects, Esophageal Stenosis etiology, Esophagoscopy adverse effects, Female, Humans, Infant, Male, Postoperative Complications epidemiology, Postoperative Complications etiology, Retrospective Studies, Treatment Outcome, Electrocoagulation methods, Esophageal Stenosis surgery, Esophagoscopy methods
- Abstract
Background and Aim: Refractory esophageal strictures are rare conditions in pediatrics, and are often due to anastomotic, congenital, or caustic strictures. Traditional treatment options include serial dilation and surgical stricture resection; endoscopic intralesional steroid injections, mitomycin C, and externally removable stents combined with dilation have had variable success rates. Although not as widely used, endoscopic electrocautery incisional therapy (EIT) has been reported as an alternative treatment for refractory strictures in a small number of adult series. The aim of the study was to evaluate the safety and efficacy of EIT in a pediatric population with refractory esophageal strictures., Methods: A retrospective chart review was conducted on all patients who underwent EIT for esophageal strictures (May 2011-September 2017) at our tertiary-care referral center. A total of 57 patients underwent EIT. Procedural success was defined as no stricture resection, appropriate diameter for age, and fewer than 7 dilations within 24 months of first EIT session. This corresponded to the 90th percentile of the observed number of dilations in the data. All patients included in the study had at least 2-year follow-up., Results: A total of 133 EIT sessions on 58 distinct anastomotic strictures were performed on 57 patients (24 girls). The youngest patient to have EIT was 3 months old and 4.8 kg. There were 36 strictures that met the criteria for refractory stricture and 22 non-refractory (NR) strictures. The median number of dilations before EIT therapy was 8 (interquartile range [IQR]: 6-10) in the refractory group and 3 (IQR: 0-3) in the NR group. In the refractory group, 61% of the patients met the criteria for treatment success. The median number of dilations within 2 years of EIT in the refractory group was 2 (IQR: 0-4). In the NR group, 100% of the patients met criteria for success. The median number of dilations within 2 years of EIT in the NR was 1 (IQR: 0-2). The overall adverse event rate was 5.3% (7/133), with 3 major (2.3%) and 4 minor events (3%)., Conclusions: EIT shows promise as an adjunct treatment option for pediatric refractory esophageal strictures and may be considered before surgical resection even in severe cases. The complication rate, albeit low, is significant, and EIT should only be considered by experienced endoscopists in close consultation with surgery. Further prospective longitudinal studies are needed to validate this treatment.
- Published
- 2018
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14. The management of synchronous bilateral Wilms tumor: a report from the National Wilms Tumor Study Group.
- Author
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Hamilton TE, Ritchey ML, Haase GM, Argani P, Peterson SM, Anderson JR, Green DM, and Shamberger RC
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- Adolescent, Age Factors, Biopsy, Needle, Boston, Child, Child, Preschool, Combined Modality Therapy, Disease-Free Survival, Female, Humans, Immunohistochemistry, Infant, Kidney Neoplasms mortality, Male, Neoplasm Recurrence, Local mortality, Neoplasm Recurrence, Local therapy, Neoplasm Staging, Neoplasms, Multiple Primary mortality, Neoplasms, Multiple Primary pathology, Neoplasms, Multiple Primary therapy, Nephrectomy methods, Nephrectomy mortality, Prognosis, Registries, Retrospective Studies, Risk Assessment, Sex Factors, Survival Rate, Treatment Outcome, Wilms Tumor mortality, Kidney Neoplasms pathology, Kidney Neoplasms therapy, Neoadjuvant Therapy methods, Neoplasm Recurrence, Local pathology, Wilms Tumor pathology, Wilms Tumor therapy
- Abstract
Objective: To provide guidelines for future trials, we reviewed the outcomes of children with synchronous bilateral Wilms tumors (BWT) treated on National Wilms Tumor Study-4 (NWTS-4)., Methods: NWTS-4 enrolled 3335 patients including 188 patients with BWT (5.6%). Treatment and outcome data were collected., Results: Among 188 BWT patients registered with NWTS-4, 195 kidneys in 123 patients had initial open biopsy, 44 kidneys in 31 patients had needle biopsies. Although pre-resection chemotherapy was recommended, 87 kidneys in 83 patients were managed with primary resection: Complete nephrectomy 48 in 48 patients, 31 partial/wedge nephrectomies in 27 patients, enucleations 8 in 8 patients. No initial surgery was performed in 45 kidneys in 43 patients, 5 kidneys in 3 patients not coded. Anaplasia was diagnosed after completion of the initial course of chemotherapy in 14 patients (initial surgical procedure: 9 open biopsies, 4 needle biopsies, 1 partial nephrectomy). The average number of days from the start of chemotherapy to diagnosis of anaplasia was 390 (range 44-1925 days). Relapse or progression of disease occurred in 54 children. End stage renal failure occurred in 23 children, 6 of whom had bilateral nephrectomies. The 8 year event free survival for BWT with favorable histology was 74%, and overall survival was 89%; whereas the event free survival for BWT with unfavorable histology was 40%, overall survival was 45%., Conclusion: The current analysis of patients with BWT treated on NWTS-4 shows that preservation of renal parenchyma is possible in many patients after initial preoperative chemotherapy. The incidence of end-stage renal disease remains significantly higher in children with BWT. Future studies are warranted to address the need for earlier biopsy in nonresponsive tumors and earlier definitive surgery to recognize unfavorable histology in these high-risk patients.
- Published
- 2011
- Full Text
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