18 results on '"Heinemann M"'
Search Results
2. Infectious posterior segment diseases in the immunocompromised patient.
- Author
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Heinemann, M. -H.
- Published
- 1992
- Full Text
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3. Primary CNS lymphoma: combined treatment with chemotherapy and radiotherapy.
- Author
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DeAngelis, L M, Yahalom, J, Heinemann, M H, Cirrincione, C, Thaler, H T, and Krol, G
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- 1990
- Full Text
- View/download PDF
4. Primary CNS lymphoma.
- Author
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DeAngelis, L. M., Yahalom, J., Heinemann, M-H., Cirrincione, C., Thaler, H. T., and Krol, G.
- Published
- 1990
- Full Text
- View/download PDF
5. Pregnancy and the thyroid gland.
- Author
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PETERS, JOHN P., MAN, EVELYN B., HEINEMANN, MARTIN, PETERS, J P, MAN, E B, and HEINEMANN, M
- Published
- 1948
- Full Text
- View/download PDF
6. Bilateral optic neuropathy with IgGkappa multiple myeloma improved after myeloablative chemotherapy.
- Author
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Lieberman, F S, Odel, J, Hirsh, J, Heinemann, M, Michaeli, J, and Posner, J
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- 1999
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- View/download PDF
7. CT OF THE SCLERA.
- Author
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Louis, L. Saint, Lee, B. C. P., Heinemann, M. H., and Chang, S.
- Published
- 1983
- Full Text
- View/download PDF
8. Refractive Shifts and Changes in Corneal Curvature Associated With Antibody-Drug Conjugates.
- Author
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Canestraro J, Hultcrantz M, Modi S, Hamlin PA, Shoushtari AN, Konner JA, Tew WP, Iyengar NM, Heinemann M, Abramson DH, and Francis JH
- Subjects
- Corneal Topography, Humans, Refraction, Ocular, Retrospective Studies, Hyperopia, Immunoconjugates, Myopia, Refractive Errors
- Abstract
Purpose: Antibody-drug conjugates (ADCs) are a class of cancer drug wherein some are associated with corneal abnormalities, but there is a dearth of published information on refractive shifts in patients receiving ADCs. Here, we evaluated the dynamics of refractive error and keratometry readings in patients with ADC-related keratopathy and microcyst-like epithelial changes (MECs)., Methods: This study is a retrospective case series including 58 eyes of 29 patients with ADC-related keratopathy from a single tertiary care cancer referral center (MSKCC). One eye (29 total) was randomly assigned for statistical analysis. In addition, a subset analysis of MEC location-refractive error correlation was performed on 20 eyes. Clinical records including slitlamp examination, indirect ophthalmoscopy, calculated spherical equivalence (SE), keratometry, and visual acuity were recorded at baseline, during, and off treatment., Results: A subset analysis of MEC location-refractive error correlation of 20 eyes revealed the following: Peripheral MECs were significantly associated with hyperopic shifts (P value < 0.001) and paracentral/central associated with myopic shifts (P value < 0.001). In the full cohort and on drug, the greatest change in SE from baseline was myopic (68%, as high as -4.75 D) and hyperopic (32%, as much as +3.75 D). Eighty-nine percent had a change in vision from baseline while on drug, but at the 3-month follow-up off drug, SE and vision returned to baseline in 33% and 82% of eyes., Conclusions: Peripheral MECs were significantly associated with hyperopic shifts, and paracentral/central MECs were associated with myopic shifts. While on drug, most eyes had a myopic refractive shift, which corresponded with corneal steepening., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
9. Multiple Sequential Free Flap Reconstructions of the Head and Neck: A Single-Center Experience.
- Author
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Moratin J, Horn D, Heinemann M, Metzger K, Mrosek J, Ristow O, Engel M, Freudlsperger C, Freier K, and Hoffmann J
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- Adolescent, Adult, Aged, Aged, 80 and over, Feasibility Studies, Female, Head surgery, Head and Neck Neoplasms psychology, Humans, Male, Middle Aged, Neck surgery, Neoplasm Recurrence, Local psychology, Quality of Life, Reoperation methods, Retrospective Studies, Surgical Wound etiology, Surgical Wound psychology, Treatment Outcome, Young Adult, Free Tissue Flaps transplantation, Head and Neck Neoplasms surgery, Neoplasm Recurrence, Local surgery, Plastic Surgery Procedures methods, Surgical Wound surgery
- Abstract
Background: Free flap reconstruction is the standard of care in extensive defects of the head and neck area, and although most patients may be treated sufficiently with one flap, recurrence of a malignant tumor or failure of a previous reconstruction may make the use of a second (or more) flap necessary. The aim of this study was to evaluate the indications and success rates of multiple consecutive reconstructive procedures in a large cohort of patients., Methods: Nine hundred ninety-six free flap reconstructions were retrospectively analyzed and cases of sequential reconstructions in the same patient were identified. Indications, success rates, perioperative procedures, and frequently used flaps were evaluated., Results: Two hundred twenty cases of sequential microvascular reconstructions were identified, ranging from two to six flaps per patient. The overall flap success rate was 89.1 percent. A history of diabetes was identified as a risk factor for flap failure (p = 0.029). There was no association of flap loss with the number of reconstructive procedures per patient., Conclusions: The use of several free flaps in the same patient is a feasible option for patients suffering from recurrent tumors or to improve quality of life by a secondary reconstruction. A salvage free flap transfer to replace a lost transplant exhibits good success rates., Clinical Question/level of Evidence: Therapeutic, IV., (Copyright © 2021 by the American Society of Plastic Surgeons.)
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- 2021
- Full Text
- View/download PDF
10. Efficacy of the ganciclovir implant in the setting of silicone oil vitreous substitute.
- Author
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McGuire DE, McAulife P, Heinemann MH, and Rahhal FM
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- Cytomegalovirus Retinitis complications, Drug Evaluation, Drug Implants, Humans, Pilot Projects, Retinal Detachment etiology, Retrospective Studies, Safety, Treatment Outcome, Vitreous Body, Antiviral Agents administration & dosage, Cytomegalovirus Retinitis drug therapy, Ganciclovir administration & dosage, Retinal Detachment drug therapy, Silicone Oils therapeutic use
- Abstract
Objective: To evaluate the efficacy of the ganciclovir implant in the setting of silicone oil vitreous substitute., Materials and Methods: The authors retrospectively reviewed the charts of 19 patients with cytomegalovirus retinitis who had both a ganciclovir implant and silicone oil vitreous substitute. None of the patients was receiving highly active antiretroviral therapy during the study period. Kaplan-Meier analysis was used to evaluate time to progression in eyes with the ganciclovir implant and silicone oil., Results: In all eyes, the ganciclovir device implantation preceded or coincided with silicone injection. Kaplan-Meier analysis revealed that time to 25% failure from the date of the presence of both the implant and oil was 129 days. Time to 25% failure from the date of ganciclovir device implantation was 179 days., Conclusions: These results compare favorably with conventional treatment. The ganciclovir implant can be a useful treatment modality in eyes with silicone oil.
- Published
- 2000
- Full Text
- View/download PDF
11. Re-evaluation of time to progression of foscarnet salvage therapy for cytomegalovirus retinitis in AIDS patients clinically resistant to ganciclovir.
- Author
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Mueller AJ, Jacobson MA, Hurwitz S, Chuang EL, Friedberg DN, Haidt SJ, Heinemann MH, Jabs DA, Kaplan HJ, and Freeman WR
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- Cytomegalovirus Retinitis complications, Disease Progression, Humans, AIDS-Related Opportunistic Infections drug therapy, Antiviral Agents therapeutic use, Cytomegalovirus Retinitis drug therapy, Foscarnet therapeutic use, Ganciclovir therapeutic use, Reverse Transcriptase Inhibitors pharmacology, Salvage Therapy
- Published
- 1997
12. Ophthalmic, ultrasonographic findings in primary central nervous system lymphoma with ocular involvement.
- Author
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Ursea R, Heinemann MH, Silverman RH, Deangelis LM, Daly SW, and Coleman DJ
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- Adolescent, Adult, Aged, Anterior Eye Segment diagnostic imaging, Anterior Eye Segment pathology, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Biopsy, Brain Neoplasms pathology, Brain Neoplasms therapy, Choroid diagnostic imaging, Choroid pathology, Eye Neoplasms pathology, Eye Neoplasms therapy, Female, Humans, Lymphoma pathology, Lymphoma therapy, Male, Middle Aged, Optic Nerve diagnostic imaging, Optic Nerve pathology, Retina diagnostic imaging, Retina pathology, Ultrasonography, Vitrectomy, Vitreous Body diagnostic imaging, Vitreous Body pathology, Brain Neoplasms diagnostic imaging, Eye Neoplasms diagnostic imaging, Lymphoma diagnostic imaging
- Abstract
Purpose: To describe and classify ophthalmic, ultrasonographic findings in patients with primary central nervous system lymphoma with ocular involvement., Methods: B- and A-scan ultrasonography was performed on the eyes of 13 patients with primary central nervous system lymphoma with ocular involvement., Results: In seven patients, the eyes were the site of initial involvement. In the other six patients, both ocular and central nervous system disease were present at the initial evaluation. All patients had abnormal ultrasonographic findings. The most common were vitreous debris (n = 10), choroidal-scleral thickening (n = 6), and widening of the optic nerve (n = 4). Elevated chorioretinal lesions (n = 3) and retinal detachment (n = 2) were also found., Conclusion: Ophthalmic ultrasonography is a useful adjunctive diagnostic technique for characterizing ocular involvement in lymphoma. Ocular lymphoma may present as chorioretinitis, vitreitis and nonspecific uveitis; it produces characteristic, but nonspecific findings on ultrasonography. The diagnosis of ocular involvement is an important factor in determining treatment.
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- 1997
- Full Text
- View/download PDF
13. Horner's syndrome after coronary artery bypass surgery.
- Author
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Barbut D, Gold JP, Heinemann MH, Hinton RB, and Trifiletti RR
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Risk Factors, Coronary Artery Bypass adverse effects, Horner Syndrome etiology
- Abstract
We established the frequency of Horner's syndrome (HS) in 248 elective patients after coronary artery bypass surgery. Patients were evaluated neurologically pre- and post-operatively and 6 months after surgery. Nineteen patients (7.7%) developed unilateral HS postoperatively, 12 involving the left eye. The finding persisted in 10 patients (4%) at 6 months. When assessed 2 to 6 days, or 6 months, postoperatively, HS tended to be isolated and not associated with C8/T1 plexopathy. Among nondiabetic subjects, hypertensive patients had a higher frequency of HS than normotensive patients (10.6% versus 2.9%, p = 0.05). Among normotensive subjects, diabetic patients had a higher frequency than nondiabetic patients (15% versus 2.9%, p = 0.08). There was no association between HS, age, sex, internal mammary artery grafting, or length of cardiopulmonary bypass time. In summary, HS is a common and sometimes persistent complication of coronary artery bypass surgery. Hypertensive, and possibly diabetic, patients appear to be at greatest risk for developing HS.
- Published
- 1996
- Full Text
- View/download PDF
14. Surgery extended into the aortic arch in acute type A dissection. Indications, techniques, and results.
- Author
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Heinemann M, Laas J, Jurmann M, Karck M, and Borst HG
- Subjects
- Aortic Dissection mortality, Aorta, Thoracic surgery, Aortic Aneurysm mortality, Blood Vessel Prosthesis, Emergencies, Extracorporeal Circulation, Female, Hospital Mortality, Humans, Hypothermia, Induced, Male, Middle Aged, Aortic Dissection surgery, Aortic Aneurysm surgery
- Abstract
From May of 1979 to September of 1990, 106 patients underwent emergency surgery for acute type A aortic dissection. In 29 patients (27.3% of total; mean age, 53 years) surgery was extended into the aortic arch. In 19 cases the proximal entry reached or began beyond the aortic cross-clamping site, which prevented proper reconstruction of the distal aorta. In six cases an aortic perforation was located in the arch. In four others the dissection occurred within a preexistent arch aneurysm. Operative techniques consisted of eight arch reconstructions, 17 proximal arch replacements, and four total arch replacements. Repair was performed during deep hypothermia (mean nasopharyngeal temperature, 17.8 degrees C) and circulatory arrest (mean, 24.2 minutes). Operative mortality was 20.6% (six of 29), dropping to 10.5% (two of 19) during the past 4 years. There were no late deaths in the 23 survivors, with one patient suffering from neurological sequelae. Nineteen underwent either computed tomography and digital subtraction angiography or magnetic resonance imaging without pathological findings in the ascending aorta or arch. In acute type A aortic dissection the site of the intimal tear and/or perforation, as well as preexistent aneurysmatic disease, may require primary aortic arch repair. This can be accomplished during deep hypothermia and circulatory arrest, with acceptable early and satisfactory late results.
- Published
- 1991
15. Management of thoracoabdominal malperfusion in aortic dissection.
- Author
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Laas J, Heinemann M, Schaefers HJ, Daniel W, and Borst HG
- Subjects
- Aortic Dissection surgery, Aorta, Abdominal surgery, Aorta, Thoracic surgery, Aortic Aneurysm surgery, Blood Vessel Prosthesis, Female, Humans, Male, Mesenteric Vascular Occlusion surgery, Middle Aged, Aortic Dissection complications, Aortic Aneurysm complications, Mesenteric Vascular Occlusion etiology
- Abstract
Malperfusion of the thoracoabdominal aorta or its branches is a common complication of aortic dissection, often with a fatal outcome. Since 1985 we saw thoracoabdominal malperfusion in 13 patients with aortic dissection. During repair of an acute type A aortic dissection, the intimal flap was fenestrated in three cases in the abdominal aorta and one within the superior mesenteric artery. In two cases with acute type B aortic dissection fenestration was performed at the level of the aortic bifurcation, and in one the descending aorta was replaced. Six patients had chronic dilatation of a false lumen without distal reentry, compromising the true lumen, with malperfusion of viscera, kidneys, and lower extremities. Three patients underwent replacement of the descending aorta, two of them subsequent abdominal aortic replacement with revascularization of the kidneys. One patient had thoracoabdominal replacement, and in two an extra-anatomic bypass was implanted. Five patients with acute dissection died: two from sequelae of malperfusion, two of myocardial failure, and one late after stroke. Eight patients are alive 1 month to 5 years after operation. In acute aortic dissection fenestration of the intimal flap may relieve thoracoabdominal malperfusion. In chronic aortic dissection, pseudocoarctation is most likely to occur at the diaphragmatic hiatus. This is treated by replacement of the affected aortic segment. In high-risk patients an extra-anatomic bypass is also feasible.
- Published
- 1991
16. The degradation of human myelin basic protein peptide 43-88 by human renal neutral proteinase.
- Author
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Whitaker JN and Heinemann MA
- Subjects
- Adolescent, Adult, Aged, Amyotrophic Lateral Sclerosis metabolism, Cerebellar Diseases metabolism, Female, Humans, Male, Middle Aged, Multiple Sclerosis metabolism, Peptide Fragments metabolism, Polyradiculoneuropathy metabolism, Subacute Sclerosing Panencephalitis metabolism, Endopeptidases metabolism, Kidney enzymology, Myelin Basic Protein metabolism, Nervous System Diseases metabolism
- Abstract
Normal human kidney contains a neutral endopeptidase that can degrade human myelin basic protein peptide 43-88. In the present study, renal homogenates prepared from postmortem tissue obtained from four persons with multiple sclerosis, two with amyotrophic lateral sclerosis, one each with olivopontocerebellar atrophy, subacute sclerosing panencephalitis, and Guillain-Barré syndrome, and four controls were analyzed for the enzymes present that degrade human myelin BP peptide 43-88. There was no evidence that the activity in renal tissue for degrading human BP peptide 43-88 is qualitatively different in persons with MS, other neurologic diseases, or controls. Gel filtration of digested peptide demonstrated the action of an endopeptidase capable of hydrolyzing BP peptide 43-88 into large fragments.
- Published
- 1983
- Full Text
- View/download PDF
17. Leukotrienes levels in the aqueous humor following experimental ocular trauma.
- Author
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Latanza L, Alfaro DV, Bockman R, Iwamoto T, Heinemann MH, and Chang S
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- Animals, Eicosanoic Acids, Inflammation metabolism, Male, Rabbits, Radioimmunoassay, Wounds, Nonpenetrating metabolism, Aqueous Humor analysis, Eye Injuries metabolism, Leukotriene B4 analysis, SRS-A analysis
- Abstract
Using radioimmunoassay technique, levels of leukotriene B4 and C4 (LTB4 and LTC4) in the aqueous humor of rabbit eyes were measured following experimental nonpenetrating ocular trauma. Slit lamp examination showed a time-dependent increase of flare, cells, and fibrin in the anterior chamber of the traumatized eyes. Polymorphonuclear (PMN) leukocyte influx into the aqueous humor was not seen at 6 hours but increased significantly in traumatized eyes after 12 hours. No inflammatory cells were observed in control eyes. Histopathologic studies demonstrated injuries of the ciliary body, ruptures of the retina and choroid, with intraocular hemorrhage. LTB4 values peaked at 6 hours, prior to PMN cell infiltration and remained significantly higher than controls, which remained undetectable at all intervals after injury. LTC4 values also peaked by 6 hours in the traumatized eyes. These data demonstrate that elevations in LTB4 and LTC4 are associated with blunt trauma, and this precedes PMN cell infiltration. Leukotrienes may play a role in the early inflammatory response following concussive ocular injuries.
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- 1988
- Full Text
- View/download PDF
18. Bilateral toxoplasma retinochoroiditis in a patient with acquired immune deficiency syndrome.
- Author
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Heinemann MH, Gold JM, and Maisel J
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- Adult, Humans, Male, Acquired Immunodeficiency Syndrome complications, Choroiditis etiology, Retinitis etiology, Toxoplasmosis etiology
- Abstract
A 32-year-old patient with acquired immune deficiency syndrome (AIDS) was evaluated for bilateral visual loss accompanied by uveitis, vitritis and retinochoroiditis. Diagnostic vitrectomy was performed on the right eye, and the diagnosis of ocular toxoplasmosis made. Central nervous system involvement was suggested by ring enhancing lesions on CT scan. The patient improved on a pyrimethamine, sulfadiazine and clindamycin, but succumbed to disseminated toxoplasmosis when treatment was discontinued.
- Published
- 1986
- Full Text
- View/download PDF
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