7 results on '"Huang, HaiPeng"'
Search Results
2. Co‐regulation of hepatic steatosis by ferritinophagy and unsaturated fatty acid supply.
- Author
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Li, Ning, Liao, Yilie, Huang, Haipeng, and Fu, Suneng
- Subjects
UNSATURATED fatty acids ,FATTY liver ,IRON overload ,IRON ,LIPID metabolism - Abstract
Both iron overload and iron deficiency have been reported in obesity and metabolic syndromes. Due to the presence of multiple intracellular iron pools and the dynamic nature of iron mobilization and use, the actual status and contribution of free and metabolically active iron toward metabolic syndrome remain to be established. The discovery of nuclear receptor coactivator 4 (NCOA4) as a ferritinophagy receptor provides an opening to address the connection between iron and metabolic diseases. This study aims to specifically dissect the role of hepatic ferritinophagy in lipid metabolism and hepatic steatosis. We conducted a series of Ncoa4 gain‐ and loss‐of‐function experiments to examine how ferritinophagy affects lipid metabolism through phenotypic and lipidomic analyses both in vitro and in vivo. We show that ferritinophagy is required to release iron from ferritin cages for biological use, and is induced by lipid loading in vitro and during the development of obesity in vivo. Ncoa4 knockdown impairs mitochondrial morphology and reduces palmitate‐induced lipid droplet formation in cultured cells and the development of hepatic steatosis in obese mice models. Importantly, the effect of Ncoa4 deficiency on mitochondrial morphology and lipid accumulation is specifically linked to lipidomic reductions in unsaturated fatty acid content in triglycerides and cardiolipins, and an external supply of unsaturated fatty acids reverses these phenotypes. Conclusion: This study shows that ferritinophagy‐derived iron supports fatty acid desaturation and the synthesis of unsaturated fatty acid–rich lipids to reduce lipotoxicity. However, the continuous activation of ferritinophagy contributes to the development of hepatic steatosis and liver damage in obesity. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
3. Study on acupuncture improving insomnia comorbid with depression and anxiety based on rs-fMRI
- Author
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Yao, Lin, Li, Mengyuan, Cao, Jiazhen, Liu, Yanze, Zheng, Haizhu, Huang, Haipeng, and Wang, Hongfeng
- Subjects
Depression ,insomnia ,Rest ,Acupuncture Therapy ,Brain ,Comorbidity ,Anxiety ,anxiety ,Magnetic Resonance Imaging ,meta-analysis ,Treatment Outcome ,systematic review ,Meta-Analysis as Topic ,Sleep Initiation and Maintenance Disorders ,Study Protocol Systematic Review ,depression ,Humans ,protocol ,acupuncture ,rs-fMRI ,Research Article ,Randomized Controlled Trials as Topic ,Systematic Reviews as Topic - Abstract
Background: Long term insomnia and low sleep quality often lead to depression, anxiety and other negative emotions, and often interact with each other. Many studies have confirmed the effectiveness of acupuncture in the treatment of insomnia comorbid with emotional disorders, but its specific mechanism needs to be further explored. Resting-state functional magnetic resonance (rsfMRI) is an important means to study the changes of brain activity. However, the results are inconsistent and lack of systematic evaluation and analysis. Methods: Nine databases will be searched, including PubMed, EMBASE, EBSCOhost-medline, Web of Science, Cochrane Library, China National Knowledge Infrastructure, VIP Database and Wan-Fang Database, Chinese Biomedical Literature Database from inception to January 2021. And screening clinical registration platform related research, in order to obtain more relevant studies. The outcomes include the change of rs-fMRI, sleep quality, depression, and anxiety. Quality assessment of the included studies will be performed according to the Cochrane Risk of Bias tool. Evidence quality will be assessed by using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. RevMan software (Version 5.3) and stata13.1will be used for statistical analyses. Subgroup analysis will be performed if necessary. If the data is insufficient, qualitative synthesis will be conducted instead of quantitative synthesis. Results: This study will analyze the effect of acupuncture on the brain activity changes, improvement of sleep quality and clinical symptoms of anxiety and depression with insomnia comorbid with emotional disorders. Conclusion: This study used meta-analysis method to explore the characteristics of acupuncture on brain activity changes in insomnia comorbid with emotional disorders, so as to provide effective evidence for clarifying its pathogenesis.
- Published
- 2021
4. Acupuncture for type 2 diabetes mellitus with nonalcoholic fatty liver disease: A protocol for systematic review and meta-analysis.
- Author
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Mengyuan Li, Lin Yao, Haipeng Huang, Guan Wang, Bin Yu, Haizhu Zheng, Hongfeng Wang, Li, Mengyuan, Yao, Lin, Huang, Haipeng, Wang, Guan, Yu, Bin, Zheng, Haizhu, and Wang, Hongfeng
- Published
- 2021
- Full Text
- View/download PDF
5. Study on acupuncture improving insomnia comorbid with depression and anxiety based on rs-fMRI: A protocol for systematic review and meta-analysis.
- Author
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Lin Yao, Mengyuan Li, Jiazhen Cao, Yanze Liu, Haizhu Zheng, Haipeng Huang, Hongfeng Wang, Yao, Lin, Li, Mengyuan, Cao, Jiazhen, Liu, Yanze, Zheng, Haizhu, Huang, Haipeng, and Wang, Hongfeng
- Published
- 2021
- Full Text
- View/download PDF
6. Prognostic analysis of anoikis-related genes in bladder cancer: An observational study.
- Author
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Huang F, Zhou L, Sun J, Ma X, Pei Y, Zhang Q, Yu Y, He G, Zhu L, Li H, Wang X, Long F, Huang H, Zhang J, and Sun X
- Subjects
- Humans, Prognosis, Male, Female, Middle Aged, Gene Expression Regulation, Neoplastic, Aged, Survival Rate, Gene Expression Profiling methods, Biomarkers, Tumor genetics, Urinary Bladder Neoplasms genetics, Urinary Bladder Neoplasms mortality, Anoikis genetics
- Abstract
Anoikis is proved to play a crucial role in the development of cancers. However, the impact of anoikis on the prognosis of bladder cancer (BLCA) is currently unknown. Thus, this study aimed to find potential effect of anoikis in BLCA. The Cancer Genome Atlas (TCGA)-BLCA and GSE13507 cohorts were downloaded from TCGA and the Gene Expression Omnibus (GEO) databases, respectively. Differentially expressed genes (DEGs) were screened between BLCA and normal groups, which intersected with anoikis-related genes to yield anoikis-related DEGs (AR DEGs). Univariate COX, rbsurv, and multivariate COX analyses were adopted in order to build a prognostic risk model. The differences of risk score in the different clinical subgroups and the relevance between survival rate and clinical characteristics were explored as well. Finally, chemotherapy drug sensitivity in different risk groups was analyzed. In total, 78 AR DEGs were acquired and a prognostic signature was build based on the 6 characteristic genes (CALR, FASN, CSPG4, HGF, INHBB, SATB1), where the patients of low-risk group had longer survival time. The survival rate of BLCA patients was significantly differential in different groups of age, stage, smoking history, pathologic-T, and pathologic-N. The IC50 of 56 drugs showed significant differences between 2 risk groups, such as imatinib, docetaxel, and dasatinib. At last, the results of real time quantitative-polymerase chain reaction (RT-qPCR) demonstrated that the expression trend of CALR, HGF, and INHBB was consistent with the result obtained previously based on public databases. Taken together, this study identified 6 anoikis-related characteristic genes (CALR, FASN, CSPG4, HGF, INHBB, SATB1) for the prognosis of BLCA patients, providing a scientific reference for further research on BLCA., Competing Interests: The authors declare there is no potential conflict of interests., (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2024
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7. Acupuncture for type 2 diabetes mellitus with nonalcoholic fatty liver disease: A protocol for systematic review and meta-analysis.
- Author
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Li M, Yao L, Huang H, Wang G, Yu B, Zheng H, and Wang H
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- Acupuncture Therapy adverse effects, Biomarkers blood, Blood Glucose analysis, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 metabolism, Humans, Meta-Analysis as Topic, Non-alcoholic Fatty Liver Disease diagnosis, Non-alcoholic Fatty Liver Disease etiology, Non-alcoholic Fatty Liver Disease metabolism, Quality of Life, Randomized Controlled Trials as Topic, Systematic Reviews as Topic, Treatment Outcome, Acupuncture Therapy methods, Diabetes Mellitus, Type 2 therapy, Non-alcoholic Fatty Liver Disease therapy
- Abstract
Background: T2DM with NAFLD is a common disorder of glucose and lipid metabolism affecting the quality of life of patients. Due to the limitations and adverse reactions of drug treatment, acupuncture has been proved to be an effective method for the treatment of T2DM with NAFLD. This study aims to evaluate the efficacy and safety of acupuncture in the treatment of NAFLD in T2DM class, and to provide high-quality evidence for acupuncture in the treatment of this disease., Methods: From establishment of the database to 31 July 2021, We will search the Cochrane Central Register of controlled trials, PubMed, MEDLINE, EMBASE, Web of science. Five Chinese databases, including China National Knowledge Infrastructure (CNKI), WanFang database, VIP, Chinese Biomedical Literature Database (CBM) and the Chinese clinical trial registry. There are no restrictions on language or publication, and they are independently screened and collected by two reviewers. Review Manager 5.3 software will be used for meta analysis. If necessary, heterogeneity testing, data synthesis, and subgroup analysis will be performed., Results: The effectiveness and safety of acupuncture in the treatment of T2DM with NAFLD will be assessed by the outcomes of test's, including: imaging indicators, biomarkers of hepatic steatosis, serological indicators of hepatic fibrosis, improvement of serum NAFLD liver fat score, BMI, blood glucose indexes, blood lipid indexes, insulin level and safety indicators., Conclusion: This meta-analysis will further determine the beneficial efficacy and safety of acupuncture for T2DM combined with NAFLD., Competing Interests: The authors have no conflicts of interests to disclose., (Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2021
- Full Text
- View/download PDF
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