1. Lower Susceptibility to Cerebral Small Vessel Disease in Human Familial Longevity The Leiden Longevity Study
- Author
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Anton J. M. de Craen, Rudi G. J. Westendorp, Jeroen van der Grond, P. Eline Slagboom, Irmhild Altmann-Schneider, Andrea B. Maier, Mark A. van Buchem, Neuromechanics, and AMS - Ageing and Morbidity
- Subjects
Male ,medicine.medical_specialty ,Offspring ,brain ,Population ,Longevity ,Disease ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,longevity ,SDG 3 - Good Health and Well-being ,Internal medicine ,medicine ,magnetic resonance imaging ,Humans ,Genetic Predisposition to Disease ,Longitudinal Studies ,education ,Stroke ,Aged ,Netherlands ,Advanced and Specialized Nursing ,Aged, 80 and over ,education.field_of_study ,neuroimaging ,medicine.diagnostic_test ,business.industry ,cerebral small vessel disease ,aging ,Magnetic resonance imaging ,Odds ratio ,Middle Aged ,medicine.disease ,Hyperintensity ,Confidence interval ,Surgery ,Cerebral Small Vessel Diseases ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Abstract
Background and purpose— On MRI, cerebral white matter lesions, lacunar infarcts, and cerebral microbleeds are common imaging correlates of cerebral small vessel damage in apparently healthy elderly individuals. We investigated whether middle-aged to elderly offspring of nonagenarian siblings, who are predisposed to become long-lived as well, have a lower prevalence of white matter lesions, lacunar infarcts, and cerebral microbleeds than control subjects. Methods— All subjects were from the Leiden Longevity Study. In this study, middle-aged to elderly offspring of nonagenarian siblings, who are predisposed to become long-lived as well, were contrasted to their spouses. Cerebral small vessel disease was assessed using 3-T MRI. Results— Offspring were less likely to have severe periventricular frontal caps (odds ratio [OR], 0.3; 95% confidence interval [CI], 0.1–1.1; P trend=0.01) and severe periventricular bands (OR, 0.4; 95% CI, 0.2–0.8; P trend=0.02). Moreover, offspring were less likely to have frontal (OR, 0.4; 95% CI, 0.2–0.9; P trend=0.05), parietal (OR, 0.4; 95% CI, 0.1–0.9; P trend=0.001), temporal (OR, 0.3; 95% CI, 0.1–0.8]; P trend=0.004), and occipital subcortical white matter lesions (OR, 0.3; 95% CI, 0.1–0.6; P trend=0.001). Prevalence of lacunar infarcts also was lower in offspring (OR, 0.3; 95% CI, 0.1–1.1; P =0.07). Prevalence of microbleeds was not significantly different in offspring and control subjects. Conclusions— Exceptional familial longevity is associated with a lower susceptibility to white matter lesions and lacunar infarcts, but not cerebral microbleeds.
- Published
- 2013
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