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Background: Previous research has shown that appropriate pediatric postintubation sedation (PIS) after rapid sequence intubation only occurs 28% of the time. Factors such as high provider variability, cognitive overload, and errors of omission can delay time to PIS in a paralyzed patient. Purpose: To increase the proportion of children receiving timely PIS by 20% within 6 months. Methods: A multidisciplinary team identified key drivers and targeted interventions to improve timeliness of PIS. The primary outcome of "sedation in an adequate time frame" was defined as a time to post-Rapid Sequence Intubation sedative administration less than the duration of action of the RSI sedative agent. Secondary outcomes included the proportion of patients receiving any sedation and time to PIS administration. Results: Pediatric postintubation sedation in an adequate time was improved from 27.9% of intubated patients to 55.6% after intervention (p =.001). The number of patients receiving any PIS improved from 74% to 94% (p =.006). The median time from RSI to PIS was reduced from 13 to 9 minutes (p <.001). Process control charts showed a reduction in PIS variability and a centerline reduction from 19 to 10 minutes. Conclusions: Implementation of an intubation checklist and a multidisciplinary approach improved the rate of adequate pediatric PIS. [ABSTRACT FROM AUTHOR]