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Your search keyword '"LIOTTA, GIUSEPPE"' showing total 12 results
Start Over Author "LIOTTA, GIUSEPPE" Publisher lippincott williams & wilkins
12 results on '"LIOTTA, GIUSEPPE"'

9. Serum Phosphate and Creatinine Levels in the First Year of Life in Infants Born to HIV-Positive Mothers Receiving Tenofovir-Based Combination Regimens During Pregnancy and Prolonged Breastfeeding in an Option B+ Program in Malawi.

Author

Floridia, Marco, Liotta, Giuseppe, Andreotti, Mauro, Galluzzo, Clementina M., Jere, Haswell, Sagno, Jean-Baptiste, Mancinelli, Sandro, Amici, Roberta, Marazzi, Maria C., Vella, Stefano, Giuliano, Marina, and Palombi, Leonardo

Published
2016
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11. Extended antenatal use of triple antiretroviral therapy for prevention of mother-to-child transmission of HIV-1 correlates with favorable pregnancy outcomes.

Author

Marazzi MC, Palombi L, Nielsen-Saines K, Haswell J, Zimba I, Magid NA, Buonomo E, Scarcella P, Ceffa S, Paturzo G, Narciso P, and Liotta G

Subjects
Adult, Drug Therapy, Combination methods, Female, HIV Infections drug therapy, HIV Infections transmission, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Malawi, Maternal Mortality, Mozambique, Pregnancy, Pregnancy Complications, Infectious drug therapy, Prenatal Care methods, Retrospective Studies, Stillbirth, Young Adult, Anti-HIV Agents therapeutic use, HIV Infections prevention & control, HIV-1, Infectious Disease Transmission, Vertical prevention & control, Nevirapine therapeutic use, Pregnancy Complications, Infectious prevention & control
Abstract

Objective: To evaluate pregnancy outcomes in a cohort of HIV-infected women receiving triple antiretroviral therapy (ART) for prevention of mother-to-child-transmission., Methods: A retrospective cohort study with review of records of 3273 HIV-positive women receiving prenatal care in Malawi and Mozambique from July 2005 to December 2009 was conducted in Drug Resource Enhancement Against AIDS and Malnutrition (DREAM) centers. Patients were offered nevirapine-based triple ART initiated in pregnancy until 6 months postpartum. Main outcome measures were maternal mortality, abortion/stillbirth, prematurity, and low birth weight., Results: Maternal mortality was 1.2% (42/3273): 7.4% in 68 women with no antenatal ART and 0.7% in 1370 with at least 90 days of antenatal ART [P < 0.001; odds ratio (OR) 0.29 (95% confidence interval [CI] 0.14-0.96]. Abortion/stillbirth was 5.2% (169/3273): 26.5% in 68 women with no ART and 5.0% in 1370 women with at least 90 days of antenatal ART [P < 0.001; OR 0.39 (95% CI 0.27-0.57)]. Prematurity was 19.1%: 70% in 10 women with no antenatal ART and 8.5% in 1330 women with at least 90 days of antenatal ART [P < 0.001; OR 0.15 (95% CI 0.14-0.19)]. Low birth weight was 11.5% (57/496) and not associated with ART duration. The protective effect of antenatal ART against mortality, fetal demise, and prematurity was independent of CD4 strata. Multivariate analysis for BMI, CD4 cell count, virus load, days in care, predelivery length of ART, and hemoglobin demonstrated an independent association between predelivery length of ART and CD4 with maternal mortality, abortion/stillbirth, and prematurity. ART toxicities were infrequent (5.2%)., Conclusion: Antenatal triple ART reduces adverse pregnancy outcomes in HIV-infected women.

Published
2011
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