1. Long-Term Follow-Up Study on the Uptake of Genetic Counseling and Predictive DNA Testing in Inherited Cardiac Conditions
- Author
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Lieke M. van den Heuvel, Imke Christiaans, J. Peter van Tintelen, Ellen M. A. Smets, Maxiem O. van Teijlingen, Wilma P. van der Roest, Irene M. van Langen, Health Psychology Research (HPR), Cardiovascular Centre (CVC), Graduate School, ACS - Heart failure & arrhythmias, APH - Personalized Medicine, APH - Quality of Care, Medical Psychology, and ACS - Pulmonary hypertension & thrombosis
- Subjects
0301 basic medicine ,Proband ,cardiomyopathies ,Adult ,Male ,Long term follow up ,Genetic counseling ,Genetic Counseling ,030204 cardiovascular system & hematology ,030105 genetics & heredity ,Dna testing ,Bioinformatics ,Sudden cardiac death ,03 medical and health sciences ,0302 clinical medicine ,death ,Medicine ,Humans ,genetics ,Genetic Testing ,risk ,Retrospective Studies ,business.industry ,Genetic variants ,Genetic Variation ,General Medicine ,Original Articles ,DNA ,Middle Aged ,medicine.disease ,Long QT Syndrome ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Female ,business ,Follow-Up Studies - Abstract
Supplemental Digital Content is available in the text., Background: Inherited cardiac conditions present with a wide range of symptoms and may even result in sudden cardiac death. Relatives of probands with a confirmed pathogenic genetic variant are advised predictive DNA testing to enable prevention and treatment. In 2 previous cohort studies of 115 probands with a pathogenic variant, family uptake of genetic counseling was assessed in the first year(s) after test result disclosure to the proband. This study assesses uptake in these cohorts in the 14 to 23 years following disclosure. Methods: Uptake was determined retrospectively using patient records. First-degree relatives, and second-degree relatives of a deceased first-degree relative suspected of having an inherited cardiac condition, were considered eligible. Results: Of 717 eligible relatives (598 first-degree and 119 second-degree relatives), 60% attended genetic counseling. Most of them (68.6%) attended genetic counseling in the first year. A total of 98.4% of counseled relatives pursued predictive DNA testing. A total of 49.2% was identified as carrier. Median time between disclosure to the proband and counseling of relatives was 6 months (range: 0–187 months). Attending genetic counseling was observed more frequently in first-degree relatives, female relatives, primary arrhythmia syndromes, relatives with manifest inherited cardiac condition, relatives without children and families with sudden cardiac death in first-degree relatives
- Published
- 2020