1. Nevirapine Inhibits the Anti-HIV Activity of CD8+ Cells.
- Author
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Liu, Lianxing, Wang, Lin, Huang, Liusheng, Siu, Vincent, Teque, Fernando, Aweeka, Francesca T., and Levy, Jay A.
- Abstract
Antiretroviral therapy (ART) significantly reduced the CD8+ cell noncytotoxic anti-HIV response in 12 HIV-1-infected subjects (P < 0.0001). In separate experiments, CD8+ cells from long-term survivors were cocultured with HIV-infected CD4+ cells using varying concentrations of anti-HIV drugs. The antiviral function of CD8+ cells from 4 of the 14 LTSs was reduced with exposure to 10 μM of nevirapine (P < 0.05). The antiviral activity of CD8+ cells from 2 LTSs was inhibited by 5 μM of zidovudine. These studies indicate that nevirapine and probably zidovudine can inhibit the anti-HIV activity of CD8+ cells and thus could influence the effectiveness of antiretroviral therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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