37 results on '"Makita K"'
Search Results
2. Effects of human atrial natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair.
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Mitaka C, Kudo T, Jibiki M, Sugano N, Inoue Y, Makita K, and Imai T
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- 2008
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Catalog
3. Relation between climacteric symptoms and ovarian hypofunction in middle-aged and older Japanese women.
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Kasuga M, Makita K, Ishitani K, Takamatsu K, Watanabe K, Plotnikoff GA, Horiguchi F, and Nozawa S
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- 2004
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4. Relationship between airway pressure and the distribution of gas-liquid interface during partial liquid ventilation in the oleic acid lung injury model: fluorine-19 magnetic resonance imaging study.
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Uchida, T, Makita, K, Nakazawa, K, and Yokoyama, K
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- 2000
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5. Laryngeal mask airway insertion using propofol without muscle relaxants: a comparative study of pretreatment with midazolam or fentanyl.
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Nakazawa, K., Hikawa, Y., Maeda, M., Tanaka, N., Ishikawa, S., Makita, K., and Amaha, K.
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LARYNGEAL surgery ,MIDAZOLAM ,FENTANYL ,AIRWAY (Anatomy) - Abstract
SummaryWe determined the effects of pretreatment with midazolam or fentanyl on the ease of laryngeal mask airway insertion using propofol without a muscle relaxant. One hundred and eighty ASA class I or II patients were randomly allocated to one of three groups, 60 patients per group, to receive either placebo (Group C), midazolam 0.05 mg kg
-1 (Group M) or fentanyl 2 μg kg-1 (Group F), respectively. Following intravenous administration of these drugs, Group C received propofol 2.5 (Group C-2.5) or 3.0 mg kg-1 (Group C-3.0). Group M and Group F received propofol 2.0 or 2.5 mg kg-1 (Group M-2.0, M-2.5, F-2.0 and F-2.5, respectively). There was a smaller incidence of severe head and limb movements on LMA insertion in Group M-2.5, Group F-2.0 and Group F-2.5 than in Group C-2.5. Airway obstruction and inadequate jaw relaxation, which were occasionally recognized in Group C and Group F patients, were not observed in Group M-2.5. Overall the ease of LMA insertion was significantly better in Group M-2.0, Group M-2.5 and Group F-2.5 than in Group C-2.5, however, the blood pressure in Group F after LMA insertion was significantly lower than in Group M. We conclude that pretreatment with midazolam 0.05 mg combined with propofol 2.5 mg kg-1 provides safe and satisfactory conditions for LMA insertion. [ABSTRACT FROM AUTHOR] more...- Published
- 1999
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6. Post-tetanic burst count and train-of-four during recovery from vecuronium-induced intense neuromuscular block under different types of anaesthesia.
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Saitoh, Y., Tanaka, H., Fujii, Y., Makita, K., and Amaha, K.
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NEUROLEPTANESTHESIA ,ISOFLURANE ,MUSCLE relaxants ,PATIENT monitoring - Abstract
Recovery of neuromuscular blockade after vecuronium 0.2 mg kg
-1 was measured by post-tetanic burst count (PTBC) and train-of-four (TOF) in 120 adult patients anaesthetized by one of four techniques: neuroIleptanaesthesia or one minimum alveolar concentration of isoflurane, enflurane, or sevoflurane. Onset of recovery was taken when there was reflex movement in response to carinal stimulation. The time course of recovery measured by burst count was similar for all four types of anaesthesia. Recovery of each of the twitches of the TOF was significantly shorter under neuroleptanaesthesia than under isoflurane, enflurane, or sevoflurane anaesthesia [times to return of T1 were 41.4±5.4, 51.5±10.6, 52.2±10.0, or 55.3±11.2 min (mean±SD). P < 0.05]. The burst count at the onset of reflex movement was less under neuroleptanaesthesia than under isoflurane, enflurane, or sevoflurane anaesthesia (16.3±4.8, 26.7±6.7, 27.7±6.8, 28.0±8.4, P < 0.05). The ratio of first twitch to control twitch at the onset of reflex movement was the same for all four types of anaesthesia. [ABSTRACT FROM AUTHOR] more...- Published
- 1998
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7. Validation of Oxygen Consumption Measurements During Artificial Ventilation.
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Nunn, J. F., Makita, K., and Royston, B.
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- 1990
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8. P-102. Relationship Between Dermato-Physiological Changes and Hormonal Status in Pre-, Peri-, and Postnienopausal Women.
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Makita, K., Ohta, H., Kawashima, T., Kinoshita, S., Takenouchi, M., and Nozawa, S.
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- 1998
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9. P-101. Changes of Vaginal Symptoms During the Course of Hormone Replacement Therapy.
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Takamatsu, K., Ohta, H., Komukai, S., Makita, K., Horiguchi, F., and Nozawa, S.
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- 1998
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10. P-100. Effect of a HMG-CoA Reductase Inhibitor Combined with Hormone Replacement Therapy on Lipid Metabolism in Japanese Women with Hypoestrogenic Lipidemia.
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Ohta, H., Makita, K., Komukai, S., Sugimoto, I., Fuyuki, T., Takamatsu, K., Horiguchi, F., and Nozawa, S.
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- 1998
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11. P-63. Urinary Levels of Pyridinium Crosslinks of Collagen and BMD Measured by DXA After Oophorectomy.
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Makita, K., Ohta, H., Suda, Y., Masuzawa, T., Ikeda, T., Komukai, S., Masuda, A., Yoshimura, Y., Taketomi, S., and Nozawa, S.
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- 1994
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12. Infliximab-Induced Granulomatous Vasculitis With Amyloid Deposition in the Tongue of a Patient With Behçet Disease.
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Iwasaki S, Watanabe T, Tsuji T, Otsuka T, Makita K, Fukasawa Y, and Ishizu A
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- Antibodies, Monoclonal, Humans, Immunosuppressive Agents, Infliximab adverse effects, Tongue, Behcet Syndrome complications, Behcet Syndrome diagnosis, Behcet Syndrome drug therapy
- Abstract
Competing Interests: The authors declare no conflict of interest.
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- 2021
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13. Neonatal Sevoflurane Exposure Induces Adulthood Fear-induced Learning Disability and Decreases Glutamatergic Neurons in the Basolateral Amygdala.
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Satomoto M, Sun Z, Adachi YU, and Makita K
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- Animals, Animals, Newborn, Blood Gas Analysis, Cell Count, Conditioning, Psychological, Genes, fos drug effects, Learning Disabilities pathology, Male, Mice, Mice, Inbred C57BL, Sevoflurane, gamma-Aminobutyric Acid metabolism, Anesthetics, Inhalation adverse effects, Basolateral Nuclear Complex pathology, Fear psychology, Glutamates, Learning Disabilities chemically induced, Learning Disabilities psychology, Methyl Ethers adverse effects, Neurons pathology
- Abstract
Background: Neonatal mice exposed to sevoflurane show certain cognitive and behavioral impairments in adulthood. However, the mechanisms underlying long-term cognitive deficits induced by sevoflurane exposure remain unknown. The present study was performed to investigate whether there is differential neuronal activation between naive mice and sevoflurane-exposed neonates in fear-conditioning tests based on immediate early gene (c-Fos) expression., Methods: Male mice were exposed to 3% sevoflurane (SEVO group) or carrier gas alone (no anesthesia, NA group) for 6 hours on postnatal day 6. The mice were allowed to mature before performing the contextual fear-conditioning test. A reduced freezing response was confirmed in the SEVO group. Neural activation in the regions of the medial prefrontal cortex, hippocampus, and amygdala was investigated using c-Fos immunostaining 2 hours after the test. The types of neurons activated were also identified., Results: The number of c-Fos-positive cells decreased by 27% in the basolateral amygdala in the SEVO group, while no significant changes were observed in other regions. Furthermore, glutamatergic, but not γ-aminobutyric acid (GABA)ergic, neurons expressed c-Fos after the contextual fear-conditioning test in both groups. The number of glutamatergic neurons in the basolateral amygdala in the SEVO group was reduced by 27%., Conclusions: Decreased neural activation in the basolateral amygdala may be associated with reduced freezing time in neonatal sevoflurane-exposed mice. Fewer glutamatergic neurons responding to fear stimuli in the basolateral amygdala may contribute to decreased neural activation and learning deficits in mice exposed to sevoflurane as neonates. more...
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- 2018
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14. Disrupted offset analgesia distinguishes patients with chronic pain from healthy controls.
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Kobinata H, Ikeda E, Zhang S, Li T, Makita K, and Kurata J
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- Adult, Aged, Female, Humans, Hypesthesia physiopathology, Male, Middle Aged, Pain Measurement, Pain Perception drug effects, Physical Stimulation, Psychophysics, ROC Curve, Reaction Time drug effects, Reaction Time physiology, Young Adult, Analgesia methods, Chronic Pain drug therapy, Pain Perception physiology
- Abstract
Offset analgesia (OA) represents a disproportionately large decrease of pain perception after a brief, temporary increment of thermal pain stimulus and was reported attenuated in patients with neuropathic pain. We examined whether OA depends on the increment duration before offset, and whether individual features of OA distinguish patients with chronic pain and healthy controls. We used a Peltier-type thermal stimulator and OA paradigms including 5-, 10-, or 15-s duration of 1°C-increment (T2) over 45°C. We first examined OA response, on the left volar forearm, at 3 different T2's in 40 healthy volunteers, and OA and constant stimulus responses in 12 patients with chronic pain and 12 matched healthy controls. We measured magnitude of OA ([INCREMENT]OA) and maximum visual analogue scale (VAS) latency (time to peak VAS) during constant stimulus for each individual. Pain perception kinetics were compared with analysis of variance and sought for correlations with psychophysical parameters with a significance threshold at P < 0.05. In healthy controls, longer T2 at 10 or 15 seconds resulted in larger [INCREMENT]OA compared with T2 at 5 seconds (P = 0.04). In patients, [INCREMENT]OA was significantly smaller than controls at T2 = 5 or 10 seconds (P < 0.05) but grew comparable at T2 = 15 seconds with controls. Maximum VAS latency was longer in patients than in controls and negatively correlated with [INCREMENT]OA in patients. An OA index ([INCREMENT]OA/[maximum VAS latency]) proved diagnostic of chronic pain with an area under the receiver operating characteristic curve at 0.897. Patients with chronic pain showed impairment of OA and reduced temporal sharpening of pain perception, which might imply possible disturbance of the endogenous pain modulatory system. more...
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- 2017
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15. Dysfunction of Nucleus Accumbens Is Associated With Psychiatric Problems in Patients With Chronic Low Back Pain: A Functional Magnetic Resonance Imaging Study.
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Kaneko H, Zhang S, Sekiguchi M, Nikaido T, Makita K, Kurata J, and Konno SI
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- Adult, Catastrophization diagnostic imaging, Catastrophization physiopathology, Catastrophization psychology, Chronic Pain physiopathology, Chronic Pain psychology, Cross-Sectional Studies, Echo-Planar Imaging, Female, Health Surveys, Humans, Low Back Pain physiopathology, Low Back Pain psychology, Magnetic Resonance Imaging, Male, Middle Aged, Nucleus Accumbens physiopathology, Pain Measurement, Severity of Illness Index, Young Adult, Chronic Pain diagnostic imaging, Low Back Pain diagnostic imaging, Mental Health, Nucleus Accumbens diagnostic imaging, Quality of Life psychology
- Abstract
Study Design: A cross-sectional study., Objective: The aim of this study was to evaluate activity of the nucleus accumbens (NAc) in response to lumbar mechanical stimulation in patients with chronic low back pain (cLBP) using functional magnetic resonance imaging (fMRI)., Summary of Background Data: Although a modified activity of the NAc was characterized in cLBP patients, its pathological significance has yet to be determined. We hypothesized that NAc activation in response to pain might differ depending on the extent of psychiatric problems, which might be associated with the affective/motivational background of chronic pain., Methods: Twenty-one patients with cLBP (four men, 17 women) were recruited. Subjects were divided into two groups on the basis of scores on the patient version of the Brief Scale for Psychiatric problems in Orthopaedic Patients (BS-POP) scores: ≥17 (High Score, HiS group) and <17 (non-High Score, non-HiS group). Each subject was placed in the prone position on a 3-Tesla magnetic resonance imaging (MRI) scanner and stimulated by mechanical stimulation on the left lower back. Three blocks of 30-second pain stimulus calibrated at either 3 or 5 on an 11-grade numerical rating scale (NRS) were applied with intervening 30-second rest conditions during whole-brain echo-planar imaging. Functional images were analyzed using a multisubject general linear model with Bonferroni multiple comparisons., Results: Subjects in the HiS group had more intense daily pain and lower quality of life than those in the non-HiS group (P < 0.05). Catastrophic thinking in relation to pain experience did not differ between the groups. Activation at the NAc was smaller in the HiS group than in the non-HiS group (P < 0.001)., Conclusion: The presence of psychiatric problems was associated with attenuated activity of the NAc in cLBP patients. Dysfunction of the NAc might potentially be involved in the affective/motivational factors in the chronification of LBP., Level of Evidence: N/A. more...
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- 2017
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16. Phenylephrine ameliorates cerebral cytotoxic edema and reduces cerebral infarction volume in a rat model of complete unilateral carotid artery occlusion with severe hypotension.
- Author
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Ishikawa S, Ito H, Yokoyama K, and Makita K
- Subjects
- Adrenergic alpha-Agonists administration & dosage, Animals, Blood Flow Velocity drug effects, Blood Pressure drug effects, Brain Edema etiology, Brain Edema pathology, Brain Edema physiopathology, Carotid Stenosis complications, Carotid Stenosis pathology, Carotid Stenosis physiopathology, Cerebral Infarction etiology, Cerebral Infarction pathology, Cerebral Infarction physiopathology, Cerebrovascular Circulation drug effects, Disease Models, Animal, Hypotension etiology, Hypotension pathology, Hypotension physiopathology, Infusions, Intravenous, Laser-Doppler Flowmetry, Magnetic Resonance Imaging, Male, Phenylephrine administration & dosage, Rats, Rats, Sprague-Dawley, Severity of Illness Index, Shock, Hemorrhagic complications, Shock, Hemorrhagic pathology, Shock, Hemorrhagic physiopathology, Time Factors, Vasoconstrictor Agents administration & dosage, Adrenergic alpha-Agonists pharmacology, Brain Edema prevention & control, Carotid Stenosis drug therapy, Cerebral Infarction prevention & control, Hypotension drug therapy, Phenylephrine pharmacology, Shock, Hemorrhagic drug therapy, Vasoconstrictor Agents pharmacology
- Abstract
Background: Phenylephrine is a selective alpha(1) adrenergic receptor agonist that increases arterial blood pressure by peripheral vasoconstriction. However, whether phenylephrine improves the outcome of cerebral ischemia in patients with internal carotid artery disease during hemorrhagic shock is unclear., Methods: (Experiment 1) Twenty-one adult male Sprague-Dawley rats were anesthetized with isoflurane and their lungs mechanically ventilated. After the right common carotid artery was ligated, arterial blood was withdrawn until mean arterial blood pressure (MAP) reached 30 mm Hg to induce cerebral ischemia. After MAP was maintained at 30 mm Hg for 10 min, the animals were randomly allocated to three groups (n = 7 each). In the phenylephrine group, phenylephrine was administered IV to maintain a MAP of 70 +/- 3 mm Hg for 5 min. In the saline group, an identical volume of normal physiologic saline was continuously administered for 5 min. In the control group, neither phenylephrine nor saline was administered and MAP was maintained at 30 mm Hg. At 30 min of exsanguination, the withdrawn blood was reinfused IV at a rate of 0.25 mL/min. Diffusion-weighted magnetic resonance images were serially acquired and apparent diffusion coefficient maps were created to determine the volume of cytotoxic edema. (Experiment 2) To analyze the effect of phenylephrine on the regional cerebral blood flow (rCBF) in the right middle cerebral artery territory, rCBF was measured using laser Doppler flowmetry in 15 additional rats (n = 5 each)., Results: (Experiment 1) At 10 min of exsanguination, there were no significant differences in the volume of cytotoxic edema among the phenylephrine (357.5 +/- 93.5 mm(3)), saline (333.5 +/- 69.6 mm(3)), and control (303.1 +/- 85.8 mm(3)) groups. Low apparent diffusion coefficient regions significantly expanded with time in the control group, whereas they started to decrease just after phenylephrine infusion and almost all had disappeared within 30 min in the phenylephrine group. The final infarction volume in the phenylephrine group (3.9 +/- 2.6 mm(3), P < 0.01) was significantly lower than that in the saline group (341.5 +/- 213.7 mm(3)) and control group (509.1 +/- 197.0 mm(3)). (Experiment 2) Although rCBF decreased to 40%-50% of the baseline at 10 min of exsanguination, phenylephrine immediately increased rCBF over the baseline level. In the saline group, rCBF increased significantly, but there was some delay compared with the phenylephrine group., Conclusions: Phenylephrine ameliorated cytotoxic edema and decreased the infarction volume in a rat model of complete unilateral carotid artery occlusion with severe hypotension. These findings suggest that phenylephrine transiently increased CBF without increasing the tonus of cerebral vasculature during hemorrhagic shock. more...
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- 2009
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17. The evolution of cerebral ischemia in a rat model of complete unilateral carotid artery occlusion with severe hypotension as detected by diffusion-, T2-, and postcontrast T1-weighted magnetic resonance images.
- Author
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Ishikawa S, Yokoyama K, and Makita K
- Subjects
- Animals, Blood Gas Analysis, Blood Glucose metabolism, Blood Pressure drug effects, Body Temperature physiology, Disease Progression, Hematocrit, Magnetic Resonance Imaging, Male, Rats, Rats, Sprague-Dawley, Brain Ischemia physiopathology, Carotid Stenosis physiopathology, Hypotension physiopathology
- Abstract
Severe internal carotid artery stenosis or occlusion is considered to be one of the important causes of stroke. The authors created a complete unilateral carotid artery occlusion model in 15 Sprague-Dawley rats, induced severe hypotension for at least 36 minutes by exsanguination with the target mean arterial pressure being equal or less than 35 mmHg, and investigated the temporal and spatial evolution of cerebral ischemia by diffusion-, T2-, and postcontrast T1-weighted magnetic resonance images. Cerebral ischemia was detected in most regions of the right middle cerebral artery territory during exsanguination. There was no significant relationship between ischemic lesion volume detected on apparent diffusion coefficient (ADC) map (ADC lesion volume) and infarction volume found on histopathology. However, there was a linear relationship between the change in ADC lesion volume at blood reinfusion (after reinfusion minus before reinfusion) and the enlargement of the lesion volume during the postreinfusion period (Y = 0.4X + 161.7, P = 0.0066) and a significant logarithmic correlation between the volume of vasogenic edema found on postcontrast T1-weighted image at 1 hour of the postreinfusion period and the enlargement of the lesion volume during the postreinfusion period (Y = 62.1 x logX - 115.4, P = 0.022). In conclusion, although it may be difficult to predict the outcome of cerebral ischemia (infarction volume) from the lesion volume during exsanguination, the evolution of cerebral ischemia may be partly predicted by lesion volume changes seen on the ADC maps at the time of the blood reinfusion or by the severity of blood-brain barrier disruption at the early stage of the postreinfusion period. more...
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- 2006
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18. Cerebral lipiodol embolism after transcatheter arterial chemoembolization of hepatocellular carcinoma.
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Takao H, Makita K, Doi I, and Watanabe T
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- Aged, Contrast Media administration & dosage, Doxorubicin administration & dosage, Humans, Intracranial Embolism diagnosis, Iodized Oil administration & dosage, Magnetic Resonance Imaging, Male, Tomography, X-Ray Computed, Carcinoma, Hepatocellular therapy, Chemoembolization, Therapeutic adverse effects, Contrast Media adverse effects, Intracranial Embolism chemically induced, Iodized Oil adverse effects, Liver Neoplasms therapy
- Abstract
A case of cerebral lipiodol embolism after transcatheter arterial chemoembolization (TACE) of hepatocellular carcinoma is presented. A 76-year-old man underwent TACE for advanced hepatocellular carcinoma. Immediately after chemoembolization, his level of consciousness deteriorated. Computed tomography revealed deposition of iodized oil in the cerebral cortex, basal ganglia, and thalami. Magnetic resonance imaging showed restricted diffusion within the thalami and basal ganglia. The patient's level of consciousness gradually improved, and all neurologic symptoms disappeared over 6 weeks. more...
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- 2005
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19. Delayed emergence from anesthesia resulting from cerebellar hemorrhage during cervical spine surgery.
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Nakazawa K, Yamamoto M, Murai K, Ishikawa S, Uchida T, and Makita K
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- Aged, Anesthesia, Female, Humans, Cerebellar Diseases etiology, Cerebral Hemorrhage etiology, Cervical Vertebrae surgery, Postoperative Complications etiology
- Abstract
Cerebellar hemorrhage is an unpredictable complication of spinal surgery. We encountered a case of cerebellar hemorrhage presenting with delayed emergence from anesthesia and hemiplegia after resection of an intradural extramedullar tumor from the cervical spine. Postoperative brain computed tomography revealed hematoma in the cerebellar vermis and right cerebellar hemisphere. The patient made a gradual recovery with conservative treatment. Although the mechanism of cerebellar hemorrhage remains speculative, loss of cerebrospinal fluid may play an important role. Cerebellar hemorrhage must therefore be considered in patients with unexplained neurological deterioration or disturbance on emergence from anesthesia after spinal surgery. more...
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- 2005
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20. Plastic change of N-type Ca channel expression after preconditioning is responsible for prostaglandin E2-induced long-lasting allodynia.
- Author
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Yokoyama K, Kurihara T, Makita K, and Tanabe T
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- Animals, Calcium Channels, N-Type analysis, Carrageenan pharmacology, Dose-Response Relationship, Drug, Male, Rats, Rats, Sprague-Dawley, omega-Agatoxin IVA pharmacology, omega-Conotoxin GVIA pharmacology, Calcium Channels, N-Type physiology, Dinoprostone pharmacology, Inflammation metabolism, Pain physiopathology
- Abstract
Background: Although considerable evidence indicates neuronal Ca channels play significant roles in pain perception, their possible importance in hypersensitization after acute inflammation has not been investigated., Methods: Using carrageenan for inducing hypersensitization, the authors investigated the analgesic effects of intrathecally administered N- and P/Q-type channel blockers, omega-conotoxin GVIA and omega-agatoxin IVA, respectively, and also examined the level of N-type channel expression., Results: Acute inflammation, produced by carrageenan injection in a rat hind paw, caused mechanical hypersensitivity that resolved within several days. Injection of prostaglandin E2 into the same hind paw after resolution caused a markedly prolonged mechanical allodynia lasting more than 4 h. Similar but less potent prolonged allodynia was also induced in the contralateral hind paws. Intrathecal administration of omega-conotoxin GVIA (0.03-0.3 microg) produced dose-dependent inhibition of the allodynia in both control and carrageenan-preconditioned rats. However, the potency of omega-conotoxin GVIA was significantly lower in carrageenan-preconditioned paws than in those in the contralateral and saline-preconditioned paws. In contrast, omega-agatoxin IVA (0.01-0.1 microg) did not reduce the allodynia. Significant up-regulation of N-type channel expression was observed in both dorsal root ganglia and the spinal cord ipsilateral to the carrageenan-preconditioned hind paw., Conclusions: The results suggest an aggravating role of the N-type channel in pain sensation and a selective plastic change of this channel expression that could underlie the mechanism of hypersensitization after acute inflammation. more...
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- 2003
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21. A case of difficult airway due to lingual tonsillar hypertrophy in a patient with Down's syndrome.
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Nakazawa K, Ikeda D, Ishikawa S, and Makita K
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- Anesthesia, General, Anesthesia, Inhalation, Bronchoscopy, Child, Down Syndrome complications, Edema therapy, Female, Humans, Hypertrophy, Laryngeal Masks, Laryngoscopy, Postoperative Complications therapy, Down Syndrome pathology, Intubation, Intratracheal, Palatine Tonsil pathology, Tongue pathology, Tonsillectomy methods
- Abstract
In this report, we describe airway management of symptomatic lingual tonsillar hypertrophy in a pediatric patient with Down's syndrome. Besides obstructive sleep apnea, the history included a small atrial septal defect with mild aortic regurgitation and Moyamoya disease. Anesthesia was induced with IV administration of 1 mg/kg of propofol, followed by inhalation of sevoflurane in 100% oxygen. Muscle relaxants were not used on induction. Rigid laryngoscopy could not visualize the epiglottis because of hypertrophied tonsillar tissue, and mask ventilation became difficult when spontaneous breathing stopped. We avoided using a laryngeal mask airway because of a slight bleeding tendency presumably caused by preoperative antiplatelet therapy. Fiberoptic bronchoscopy through the nasal cavity in combination with jet ventilation successfully identified the glottis and allowed nasotracheal intubation to be accomplished. After lingual tonsillectomy, the patient was extubated on the seventh postoperative day, after supraglottic edema had resolved. Fiberoptic nasotracheal intubation under inhaled anesthesia may therefore be preferable in pediatric or uncooperative patients with symptomatic lingual tonsillar hypertrophy. more...
- Published
- 2003
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22. Atrial natriuretic peptide infusion improves ischemic renal failure after suprarenal abdominal aortic cross-clamping in dogs.
- Author
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Mitaka C, Hirata Y, Habuka K, Narumi Y, Yokoyama K, Makita K, and Imai T
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- Acute Kidney Injury etiology, Animals, Aorta, Abdominal, Aortic Aneurysm surgery, Atrial Natriuretic Factor pharmacology, Cardiac Surgical Procedures adverse effects, Constriction, Dogs, Hemodynamics, Infusions, Intravenous, Kidney Function Tests, Male, Prospective Studies, Renal Circulation drug effects, Reperfusion Injury etiology, Acute Kidney Injury prevention & control, Atrial Natriuretic Factor administration & dosage, Reperfusion Injury prevention & control
- Abstract
Objective: The suprarenal abdominal aortic cross-clamping during aortic aneurysm repair causes renal dysfunction after surgery. Atrial natriuretic peptide (ANP), a hormone synthesized by the cardiac atria, induces diuresis-natriuresis and increases glomerular filtration rate. Therefore, we tested the hypothesis that prophylactic ANP infusion could limit the development of acute renal failure after aortic cross-clamping., Design: Prospective, comparative, experimental study., Setting: Laboratory at a university hospital., Subjects: Twelve male beagle dogs (10-13 kg) with mechanical ventilation under pentobarbital anesthesia., Interventions: A catheter was inserted into the femoral vein, and lactated Ringer solution (10 mL/kg/hr) was administered throughout the study period. Two groups of animals were studied: the control group (n = 6), which received saline vehicle before and after suprarenal abdominal aortic cross-clamping for 1.5 hrs; and the ANP group (n = 6), which received ANP (1 microg/kg/min) for 5 hrs, starting from 10 mins before suprarenal abdominal aortic cross-clamping until the end of procedure., Measurements and Main Results: Changes in systemic and renal hemodynamics, blood gases, and renal function were measured at baseline and 1, 2, 3, 4, and 5 hrs after aortic cross-clamping. After aortic cross-clamping, urine volume, renal blood flow, and creatinine clearance significantly (p <.01) decreased, and serum creatinine concentrations significantly (p <.01) increased, but these effects were limited by continuous ANP infusion., Conclusions: The present study shows that ANP infusion preserved renal function after suprarenal abdominal aortic cross-clamping in dogs. These results justify a trial of ANP infusion in humans during aortic aneurysm repair. more...
- Published
- 2003
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23. Anesthetic sensitivities to propofol and halothane in mice lacking the R-type (Cav2.3) Ca2+ channel.
- Author
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Takei T, Saegusa H, Zong S, Murakoshi T, Makita K, and Tanabe T
- Subjects
- Animals, Blood Gas Analysis, Blood Pressure drug effects, Body Temperature drug effects, Dose-Response Relationship, Drug, Excitatory Postsynaptic Potentials drug effects, Heart Rate drug effects, Hippocampus drug effects, In Vitro Techniques, Injections, Intravenous, Mice, Mice, Knockout, Pyramidal Cells drug effects, Sleep drug effects, Time Factors, Anesthetics, Inhalation pharmacology, Anesthetics, Intravenous pharmacology, Calcium Channels, R-Type genetics, Calcium Channels, R-Type physiology, Halothane pharmacology, Propofol pharmacology
- Abstract
Unlabelled: Because inhibition of voltage-dependent Ca(2+) channels can be a mechanism underlying general anesthesia, we examined sensitivities to propofol and halothane in mice lacking the R-type (Ca(v)2.3) channel widely expressed in neurons. Sleep time after propofol injection (26 mg/kg IV) and halothane MAC(RR) and MAC (50% effective concentrations for the loss of the righting reflex and for the tail pinch/withdrawal response, respectively) were determined. Significantly shorter propofol-induced sleep time (291.6 +/- 16.8 s versus 344.4 +/- 12.1 s) and larger halothane MAC(RR) (1.11% +/- 0.04% versus 0.98% +/- 0.03%) were observed in Ca(v)2.3 channel knockouts (Ca(v)2.3(-/-)) than in wild-type (Ca(v)2.3(+/+)) litter mates. To investigate the basis of the decreased anesthetic sensitivities in vivo, field excitatory postsynaptic potentials and population spikes (PSs) were recorded from Schaffer collateral CA1 synapses in hippocampal slices. Propofol (10-30 micro M) inhibited PSs by potentiating gamma-aminobutyric acid-ergic inhibition, and this potentiation was markedly smaller at 30 micro M in Ca(v)2.3(-/-) mice, possibly accounting for the decreased propofol sensitivity in vivo. Halothane (1.4%-2.2%) inhibited field excitatory postsynaptic potentials similarly in both genotypes, whereas 1%-2% halothane depressed PSs more in Ca(v)2.3(-/-) mice, suggesting the postsynaptic role of the R-type channel in the propagation of excitation and other mechanisms underlying the increased halothane MAC(RR) in Ca(v)2.3(-/-) mice., Implications: Because inhibition of neuronal Ca(2+) currents can be a mechanism underlying general anesthesia, we examined anesthetic sensitivities in mice lacking the R-type (Ca(v)2.3) Ca(2+) channels both in vivo and in hippocampal slices. Decreased sensitivities in mutant mice imply a possibility that agents blocking this channel may increase the requirements of anesthetics/hypnotics. more...
- Published
- 2003
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24. Atrial natriuretic peptide improves pulmonary gas exchange by reducing extravascular lung water in canine model with oleic acid-induced pulmonary edema.
- Author
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Mitaka C, Hirata Y, Habuka K, Narumi Y, Yokoyama K, Makita K, and Imai T
- Subjects
- Animals, Dogs, Male, Oleic Acid administration & dosage, Pulmonary Edema chemically induced, Atrial Natriuretic Factor pharmacology, Diuretics pharmacology, Extravascular Lung Water drug effects, Furosemide pharmacology, Hemodynamics drug effects, Kidney drug effects, Kidney physiopathology, Pulmonary Edema physiopathology, Pulmonary Gas Exchange drug effects
- Abstract
Objective: The purpose of this study was to examine and compare the effects of atrial natriuretic peptide and furosemide on pulmonary gas exchange, hemodynamics, extravascular lung water, and renal function in a dog model of oleic acid-induced pulmonary edema., Design: Prospective, comparable, experimental study., Setting: Laboratory at a university hospital., Subjects: Eighteen male beagle dogs were studied under mechanical ventilation with pentobarbital anesthesia., Interventions: Oleic acid (0.08 mL/kg) was injected and allowed for 1 hr to achieve pulmonary edema with hypoxemia at Fio2 of 0.3. After lung injury, dogs were divided into three groups; control group (n = 6) receiving saline (2.5 mL/hr for 5 hrs), atrial natriuretic peptide group (n = 6) receiving atrial natriuretic peptide (1 microg x kg(-1) x min(-1) for 5 hrs), and furosemide group (n = 6) receiving furosemide (1 mg x kg(-1) x hr(-1) for 5 hrs)., Measurements and Main Results: Hemodynamics, arterial blood gases, extravascular lung water, and renal function were measured hourly for 7 hrs after injury. Oleic acid increased extravascular lung water and induced hypoxemia. In the atrial natriuretic peptide group, extravascular lung water was significantly (p <.05) lower and Pao2 was significantly (p <.05) higher than in the control and furosemide groups, respectively. Pulmonary hypertension induced by oleic acid was attenuated by atrial natriuretic peptide infusion but not by saline or furosemide. Increased natriuresis/diuresis did not significantly differ between the atrial natriuretic peptide and the furosemide group, whereas creatinine clearance in the atrial natriuretic peptide group was significantly higher than that in the furosemide group., Conclusions: These findings suggest that atrial natriuretic peptide improves pulmonary gas exchange by reducing extravascular lung water and pulmonary arterial pressure, possibly independently from natriuresis/diuresis in oleic acid-induced pulmonary edema. more...
- Published
- 2002
- Full Text
- View/download PDF
25. Hypoxic gas flow caused by malfunction of the proportioning system of anesthesia machines.
- Author
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Ishikawa S, Nakazawa K, and Makita K
- Subjects
- Anesthesia, Inhalation, Intraoperative Complications etiology, Nitrous Oxide administration & dosage, Oxygen blood, Anesthesiology instrumentation, Equipment Failure, Hypoxia etiology
- Published
- 2002
- Full Text
- View/download PDF
26. Continuous monitoring of gastric intraluminal carbon dioxide pressure, cardiac output, and end-tidal carbon dioxide pressure in the perioperative period in patients receiving cardiovascular surgery using cardiopulmonary bypass.
- Author
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Imai T, Sekiguchi T, Nagai Y, Morimoto T, Nosaka T, Mitaka C, Makita K, and Sunamori M
- Subjects
- Aged, Aged, 80 and over, Elective Surgical Procedures, Female, Humans, Male, Middle Aged, Partial Pressure, Prospective Studies, Carbon Dioxide analysis, Cardiac Output physiology, Cardiopulmonary Bypass, Cardiovascular Surgical Procedures, Monitoring, Intraoperative, Stomach physiology
- Abstract
Objective: To verify the hypothesis that the gastric intraluminal PCO2 (PgCO2) changes independently of the change in cardiac output (CO) during and after cardiovascular surgery using cardiopulmonary bypass (CPB), and that the elevation of PgCO2 affects the patients' morbidity., Design: Prospective, noninterventional study., Setting: Medical/surgical intensive care unit and operating theater of a university hospital., Patients: Sixteen adults patients receiving elective cardiovascular surgery using CPB., Interventions: None., Measurements and Main Results: After induction of anesthesia, the patients were fitted with a gastric tube equipped at the tip with a CO2 sensor (ion-selective field effect transistor) that can continuously measure real-time PgCO2, and a pulmonary artery catheter capable of monitoring continuous CO (CCO) and end-tidal CO2. Data from the devices was uploaded to a personal computer every 2 mins until the catheter was pulled off based on clinical judgment (PgCO2 values were blinded to everyone except the investigator). One patient expired as a result of multiple organ failure subsequent to sepsis, and postoperative morbidity assessed by the peak SOFA (sequential organ failure assessment) score (mean +/- SD 6.9 +/- 3.5; range, 2-13) was correlated with the peak PgCO2 during intensive care unit stay (mean +/- SD 74.1 +/- 30.7 mm Hg; range, 45-169 mm Hg) (p < .01, by regression analysis). The peak PgCO2 during surgery (mean +/- SD 71.1 +/- 18.1 mm Hg; range, 44-115 mm Hg) had no correlation with the postoperative morbidity. From analysis of CCO before, during, and after returning from the above 60 mm Hg of PgCO2, PgCO2 changed independently of CCO., Conclusions: PgCO2 changed independently of CCO, and its postoperative elevation was related to morbidity, even in the group of patients with a good outcome. Continuous monitoring of PgCO2 is useful for the detection of morbidity and can be expected to help elucidate the pathophysiology of change of PgCO2. more...
- Published
- 2002
- Full Text
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27. A selective inhibitor for inducible nitric oxide synthase improves hypotension and lactic acidosis in canine endotoxic shock.
- Author
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Mitaka C, Hirata Y, Yokoyama K, Makita K, and Imai T
- Subjects
- Acidosis, Lactic etiology, Animals, Blood Gas Analysis, Creatinine urine, Dogs, Hydrogen-Ion Concentration, Hypotension etiology, Male, Shock, Septic metabolism, Acidosis, Lactic drug therapy, Amidines therapeutic use, Enzyme Inhibitors therapeutic use, Hemodynamics drug effects, Heterocyclic Compounds, 2-Ring therapeutic use, Hypotension drug therapy, Lipopolysaccharides, Nitric Oxide Synthase antagonists & inhibitors, Shock, Septic drug therapy
- Abstract
Objective: To investigate whether ONO-1714, a putative selective inhibitor for inducible nitric oxide synthase, modulates systemic hemodynamics, arterial blood gases, lactate concentrations, gastric mucosal perfusion, and renal and hepatic functions in endotoxic shock., Design: Prospective, randomized, controlled animal study., Setting: Laboratory at a university hospital., Subjects: Eighteen male beagle dogs (12-19 kg) under pentobarbital anesthesia., Interventions: Dogs were mechanically ventilated and monitored with a pulmonary arterial catheter and a gastric tonometer. They were divided in three groups: a) lipopolysaccharide (LPS) plus vehicle group (n = 6), which received LPS (250 ng/kg/min for 2 hrs) and saline 1 hr later; b) LPS plus ONO (0.05) group (n = 6), which received ONO-1714 (0.05 mg/kg) 1 hr after the start of LPS; c) LPS plus ONO (0.1) group (n = 6), which received ONO-1714 (0.1 mg/kg) 1 hr after the start of LPS., Measurements and Main Results: Hemodynamics, blood gas parameters, gastric intramural pH, urine output, and serum levels of lactate, transaminases, bilirubin, and creatinine were measured during a 6-hr observation period. LPS induced hypotension, lactic acidosis, gastric mucosal acidosis, and renal and hepatic dysfunction. ONO-1714 reversed the LPS-induced hypotension and lactic acidosis without deteriorating cardiac output, oxygen delivery, or gastric mucosal acidosis., Conclusions: These findings suggest that ONO-1714 is a useful agent to reverse hypotension and lactic acidosis in a canine endotoxic shock model. more...
- Published
- 2001
- Full Text
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28. Using the intubating laryngeal mask airway (LMA-Fastrach) for blind endotracheal intubation in patients undergoing cervical spine operation.
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Nakazawa K, Tanaka N, Ishikawa S, Ohmi S, Ueki M, Saitoh Y, Makita K, and Amaha K
- Subjects
- Female, Humans, Male, Middle Aged, Cervical Vertebrae surgery, Intubation, Intratracheal adverse effects, Intubation, Intratracheal instrumentation, Intubation, Intratracheal methods, Laryngeal Masks adverse effects
- Published
- 1999
29. Treatment of pulmonary hypertension and hypoxia due to oleic acid induced lung injury with intratracheal prostaglandin E1 during partial liquid ventilation.
- Author
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Nakazawa K, Uchida T, Matsuzawa Y, Yokoyama K, Makita K, and Amaha K
- Subjects
- Animals, Hemodynamics drug effects, Lung Compliance drug effects, Oleic Acid toxicity, Prostaglandins E administration & dosage, Pulmonary Circulation drug effects, Pulmonary Ventilation, Rabbits, Fluorocarbons pharmacology, Hypertension, Pulmonary drug therapy, Hypoxia drug therapy, Prostaglandins E therapeutic use, Respiratory Distress Syndrome drug therapy
- Abstract
Background: Partial liquid ventilation using perfluorocarbon liquids may be of therapeutic benefit in patients with acute respiratory failure. This study investigated the effects of prostaglandin E1 (PGE1) delivered intratracheally during partial liquid ventilation on lung function and pulmonary circulation in rabbits with acute respiratory distress syndrome., Methods: Lung injury was induced by intravenous oleic acid in adult Japanese white rabbits, 1 h after which they were divided into four groups of 10 animals. Group 1 received mechanical ventilation alone, group 2 received aerosolized PGE1 (5 microg followed by 0.1 microg x kg(-1) x min(-1)) under mechanical ventilation combined with 5 cm H2O positive end-expiratory pressure, and groups 3 and 4 received partial liquid ventilation with 15 ml/kg perflubron. Group 4 received a 5-microg bolus followed by 0.1 microg x kg(-1) x min(-1) PGE1 instilled intratracheally (not by aerosol) in combination with partial liquid ventilation. Measurements were performed at 30-min intervals for 120 min after lung injury., Results: After lung injury, hypoxemia, hypercapnia, acidosis, and pulmonary hypertension developed in all animals and were sustained in groups 1 and 2 throughout the experiment. The partial pressure of oxygen in arterial blood of animals in group 3 improved with initiation of treatment, with statistical significance achieved at the 30 and 60 min time points as compared with controls. Group 4 animals had immediate and sustained increases in the partial pressure of oxygen in arterial blood that were significant compared with all other groups during the experiment. Statistically significant reductions in mean pulmonary artery pressure were seen only in group 4 animals compared with all other groups., Conclusions: These results suggest that PGE1 delivered intratracheally during partial liquid ventilation may be a useful therapeutic strategy for patients with the acute respiratory distress syndrome. more...
- Published
- 1998
- Full Text
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30. Evaluation of residual neuromuscular block using train-of-four and double burst stimulation at the index finger.
- Author
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Saitoh Y, Nakazawa K, Makita K, Tanaka H, and Amaha K
- Subjects
- Adult, Evaluation Studies as Topic, Female, Humans, Male, Middle Aged, Neuromuscular Nondepolarizing Agents, Vecuronium Bromide, Fingers innervation, Nerve Block methods, Neuromuscular Junction
- Abstract
We examined the percentage of tactile detection of fade in response to train-of-four (TOF), double burst stimulation3,3 (DBS3,3), or DBS3,2 at the index finger compared with that at the thumb during continuous infusion of vecuronium. One hundred five adult patients were studied. At TOF ratios (T4/T1) of 0.41-0.70, fades in response to TOF were more frequently identified by tactile means at the index finger than at the thumb (58% vs 26%, P < 0.05). Similarly, at TOF ratios of 0.61-0.90, fades in response to DBS3,3 were more frequently detected at the index finger than at the thumb (55% vs 15%, P < 0.05), and at TOF ratios of 0.81-1.00, the percentage of detection of fade in response to DBS3,2 was higher at the index finger than at the thumb (72% vs 40%, P < 0.05). In addition, baseline displacement of the index finger or thumb during tactile assessment of fade in response to neurostimulation was measured videographically. The baseline displacement of the index finger was significantly less than that of the thumb (P < 0.05). In summary, the percentage of tactile detection of fade in response to neurostimulation at the index finger is higher than at the thumb, and the absence of fade in response to DBS3,3 at the index finger is a good indicator of adequate recovery from neuromuscular block. This is probably because of the smaller baseline displacement of the index finger. more...
- Published
- 1997
- Full Text
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31. Effects of carboxy-PTIO on systemic hemodynamics, liver energetics, and concentration of liver metabolites during endotoxic shock in rabbits: a 31P and 1H magnetic resonance spectroscopic study.
- Author
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Kaneda K, Yoshioka Y, Makita K, Toyooka H, and Amaha K
- Subjects
- Acidosis prevention & control, Adenosine Triphosphate analysis, Animals, Blood Pressure drug effects, Free Radical Scavengers pharmacology, Hydrogen, Hypotension prevention & control, Lipopolysaccharides, Liver drug effects, Magnetic Resonance Spectroscopy, Nitric Oxide metabolism, Phosphates analysis, Phosphorus Radioisotopes, Rabbits, Benzoates pharmacology, Imidazoles pharmacology, Liver metabolism, Shock, Septic physiopathology
- Abstract
Objective: To investigate the effects of 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO), a nitric oxide scavenger, on the lipopolysaccharide-induced hypotension, hepatocellular dysfunction, and liver damage in endotoxic rabbits., Design: Experimental, comparative study., Setting: Laboratory of a university hospital., Subjects: Eighteen Japanese white rabbits (3.0 to 3.2 kg body weight) anesthetized with ketamine-xylazine were studied., Interventions: We randomly divided the rabbits into three groups: saline controls (group 1, n = 5); animals receiving lipopolysaccharide (400 micrograms/kg) alone (group 2, n = 8); and animals receiving lipopolysaccharide plus carboxy-PTIO at a rate of 0.17 mg/kg/min for 3 hrs (group 3, n = 5). Blood gases and mean arterial pressure (MAP) were monitored. In vivo phosphorus-31 magnetic resonance spectra were continuously obtained every 30 mins. In addition, the livers were sampled and underwent fractionation at 7 hrs after lipopolysaccharide administration. The hydrophilic and hydrophobic extracts from the livers were analyzed by in vitro hydrogen-1 and phosphorus-31 magnetic resonance spectroscopy., Measurements and Main Results: After the administration of lipopolysaccharide, the first phase of decrease in MAP within 30 mins was followed by partial recovery within the next 30 mins. In group 2, MAP started to decrease progressively within 180 mins after lipopolysaccharide administration (second phase) and decreased by 33% from the baseline value to 49 +/- 9 mm Hg at 420 mins. In contrast, the infusion of carboxy-PTIO significantly attenuated the second decrease in MAP (68 +/- 10 mm Hg, at 420 mins). In group 2, a slow and progressive decrease in adenosine triphosphate (ATP) and increase in inorganic phosphate concentrations occurred from 120 mins after lipopolysaccharide administration, and continued throughout the observation period. These changes were accompanied by a progressive decrease in intracellular pH. On the other hand, in group 3, there were no significant changes in ATP and inorganic phosphate concentrations compared with the controls from 120 to 360 mins after lipopolysaccharide administration. Moreover, restorations of both arterial and hepatocellular acidosis were observed in group 3. The differences of the degree of liver damage--as determined by the total amount of phospholipid, free fatty acids concentration, and membrane fluidity--were not significant among the three groups. Three of eight rabbits in group 2 died within 7 hrs, but no animal in the other two groups died during the study., Conclusions: The results of this study indicate that the infusion of carboxy-PTIO: a) prevented the delayed hypotension associated with endotoxic shock in rabbits; b) returned the hepatocellular ATP concentrations nearly to the level of the controls and alleviated hepatocellular acidosis; c) normalized various hydrophilic metabolites, such as lactate and alanine in the liver; and d) did not exacerbate liver injury after the administration of lipopolysaccharide. These findings indicate that carboxy-PTIO, a nitric oxide scavenger, may have a positive vasopressor effect during hypodynamic septic shock without exacerbating liver injury. more...
- Published
- 1997
- Full Text
- View/download PDF
32. Comparison of oxygen consumption measurements: indirect calorimetry versus the reversed Fick method.
- Author
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Smithies MN, Royston B, Makita K, Konieczko K, and Nunn JF
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Reproducibility of Results, Calorimetry, Indirect, Cardiac Output, Oxygen blood, Oxygen Consumption, Spirometry
- Abstract
Objective: To compare measurement of oxygen consumption (VO2) by spirometry and the reversed Fick method., Design: Within-patient comparison using simultaneous measurements by the two methods, one previously calibrated on a metabolic simulator., Patients: Twenty sets of observations on eight patients (57 to 83 yrs) requiring mechanical ventilation in a critical care unit., Interventions: None during or immediately before the measurements., Measurements and Main Results: Duplicate pairs of measurements of VO2 were made with a previously validated spirometric technique and the reversed Fick method (Qt[CaO2 - CVO2]), where Qt is cardiac output, CaO2 is arterial oxygen content, and CVO2 is mixed venous oxygen content. The coefficient of variation of the difference between duplicate measurements by the former technique was only 2.53% compared with 10.4% for the latter. The mean VO2 measurement by the spirometric method was 285.7 +/- 40.7 (SD) mL/min standard temperature and pressure, dry (STPD) and for the reversed Fick method, the mean VO2 measurement was 249.3 +/- 38.5 mL/min STPD. The mean difference was 36.4 +/- 28.5 mL/min STPD (p less than .001)., Conclusions: The repeatability of the spirometric method was four times better than the reversed Fick method. The latter gave a significantly lower value that probably, in part, reflects the VO2 of the lung, which is included in the spirometric method but not in the reversed Fick measurement. more...
- Published
- 1991
- Full Text
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33. Evaluation of metabolic measuring instruments for use in critically ill patients.
- Author
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Makita K, Nunn JF, and Royston B
- Subjects
- Carbon Dioxide physiology, Evaluation Studies as Topic, Humans, Oxygen Consumption, Respiration, Calorimetry instrumentation, Calorimetry, Indirect instrumentation, Respiration, Artificial
- Abstract
We evaluated three commercial indirect calorimetry devices which are used during artificial ventilation. Commercial butane, which had an RQ of 0.615, consumes 6.40 ml oxygen, and produces 3.94 ml CO2/1 ml, was burned in a gas-tight combustion chamber in conjunction with the ventilation of a lung model. During combustion, the flow rate of butane was measured with a soapfilm flowmeter for the calculation of reference values of oxygen consumption (VO2) and CO2 production (VCO2). To investigate the effect of oxygen concentration on the accuracy of these instruments, measurements were carried out at FIO2 values of 0.3, 0.4, 0.5, and 0.6 with a fixed ventilation mode (tidal volume 500 ml; respiratory rate 16 breath/min, intermittent positive-pressure ventilation). For the Datex Deltratrac Metabolic Monitor, the mean relative errors of measured VO2, VCO2, and RQ were all within 4.0%, 2.9%, and 4.0%, respectively. For the Engstrom Metabolic Computer, the corresponding values were 1.4%, 5.7%, and 6.0%, and for the SensorMedics MMC Horizon, 5.7%, 2.9%, and 5.9%. more...
- Published
- 1990
- Full Text
- View/download PDF
34. Portosystemic collaterals on MR imaging.
- Author
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Ohtomo K, Itai Y, Makita K, Yashiro N, Yoshikawa K, Kokubo T, and Iio M
- Subjects
- Adult, Aged, Collateral Circulation, Esophageal and Gastric Varices diagnosis, Female, Humans, Hypertension, Portal etiology, Kidney blood supply, Liver Cirrhosis diagnosis, Male, Mesentery blood supply, Middle Aged, Portography, Spleen blood supply, Tomography, X-Ray Computed, Ultrasonography, Umbilical Veins pathology, Varicose Veins diagnosis, Hypertension, Portal diagnosis, Magnetic Resonance Spectroscopy, Portal System pathology
- Abstract
Fourteen patients with various portosystemic collaterals (seven esophageal varices, three paraumbilical veins, two splenorenal shunts, and two mesenteric varices) were imaged with magnetic resonance (MR) imaging using a superconducting imager. Collateral pathways were demonstrated as tortuous structures of no or low signal intensity on spin-echo image, and flow related enhancement did not cause any difficulty in evaluation. Direct sagittal images are especially useful for paraumbilical vein and coronal images for esophageal and mesenteric varix. The clinical role of MR in the assessment of portosystemic collaterals is discussed also in comparison with CT and ultrasound. more...
- Published
- 1986
- Full Text
- View/download PDF
35. Transient hepatic attenuation differences on dynamic computed tomography.
- Author
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Itai Y, Hachiya J, Makita K, Ohtomo K, Kokubo T, and Yamauchi T
- Subjects
- Adult, Aged, Humans, Male, Middle Aged, Time Factors, Liver diagnostic imaging, Tomography, X-Ray Computed methods
- Abstract
Transient hepatic attenuation differences (THAD) are occasionally noted on dynamic CT in patients with portal vein obstruction, arterioportal shunt, liver tumor, and liver abscess. We report four additional cases of THAD with unreported and/or unexplained etiology. more...
- Published
- 1987
- Full Text
- View/download PDF
36. CT and MR imaging of fatty tumors of the liver.
- Author
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Itai Y, Ohtomo K, Kokubo T, Makita K, Okada Y, Machida T, and Yashiro N
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Hepatocellular diagnostic imaging, Carcinoma, Hepatocellular pathology, Female, Humans, Lipoma diagnostic imaging, Lipoma pathology, Liver Neoplasms diagnostic imaging, Liver Neoplasms pathology, Male, Middle Aged, Carcinoma, Hepatocellular diagnosis, Lipoma diagnosis, Liver Neoplasms diagnosis, Magnetic Resonance Spectroscopy, Tomography, X-Ray Computed
- Abstract
The presence of fat in hepatic masses narrows the range of differential diagnoses down to hepatic angiomyolipoma, lipoma, adenoma, hepatoma, metastatic fatty tumors of the liver, focal fatty infiltration of the liver, and extrahepatic fatty masses such as intraperitoneal implants from malignant teratomas, and packed omentum. We report six hepatic tumors containing fat (lipoma, hepatocellular carcinoma, and calcified mass with fat-fluid level) with CT and magnetic resonance (MR) imaging. The distribution of fat was diffuse in the lipomas and some hepatocellular carcinomas and localized in other hepatocellular carcinomas and fat-fluid masses. The density ranged from - 100 to 0 HU. High intensity areas on both T1- and T2-weighted MR images corresponded to the hypodense areas on CT. more...
- Published
- 1987
- Full Text
- View/download PDF
37. CT demonstration of fluid-fluid levels in nonenhancing hemangiomas of the liver.
- Author
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Itai Y, Ohtomo K, Kokubo T, Yamauchi T, Okada Y, and Makita K
- Subjects
- Carcinoma, Hepatocellular diagnostic imaging, Diagnosis, Differential, Humans, Liver diagnostic imaging, Liver Neoplasms secondary, Ultrasonography, Hemangioma diagnostic imaging, Liver Neoplasms diagnostic imaging, Tomography, X-Ray Computed
- Abstract
A fluid-fluid level was observed in three cases of liver hemangioma and in two cases of liver cancer. The patients with hemangioma of the liver did not show enhancement on dynamic CT and the fluid-fluid levels were not detected by ultrasound in two of these patients. Fluid-fluid levels detected by CT but not by ultrasound strongly suggested the diagnosis of nonenhancing hemangioma of the liver. more...
- Published
- 1987
- Full Text
- View/download PDF
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