1. t(14;18) Translocations in Dioxin-Exposed Workers.
- Author
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Hryhorczuk D, Dardynskaia I, Hirt C, Dardynskiy O, Turner W, Ruestow P, Bartell S, Steenland K, Zvinchuk O, and Baccarelli AA
- Subjects
- Cross-Sectional Studies, Humans, Leukocytes, Mononuclear chemistry, Chloracne, Dioxins analysis, Occupational Exposure adverse effects, Occupational Exposure analysis, Polychlorinated Dibenzodioxins
- Abstract
Objective: To determine if occupational exposure to dioxins is associated with an increased frequency of t(14;18) translocations., Methods: A cross-sectional analysis of serum dioxin levels and t(14;18) frequencies in peripheral blood mononuclear cells in 218 former chemical plant workers and 150 population controls., Results: The workers had significantly higher geometric mean serum levels of 2,3,7,8-TCDD (26.2 vs 2.5 ppt) and TEQ (73.8 vs 17.7 ppt) than controls. There were no significant differences in the prevalence or frequency of t(14;18) translocations in the workers compared to controls. Among former workers with current or past chloracne who were t(14;18) positive, the frequency of translocations significantly increased with quartiles of 2,3,7,8-TCDD and TEQ., Conclusion: Chloracne appears to modulate the association between dioxin exposure and increased frequency of t(14;18) translocations., Competing Interests: Conflict of Interest: None declared., (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Occupational and Environmental Medicine.)
- Published
- 2022
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