1. Vitamin D as adjunctive therapy in refractory pulmonary tuberculosis: a case report.
- Author
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Yamshchikov, Alexandra V., Oladele, Alawode, Leonard Jr., Michael K, Blumberg, Henry M., Ziegler, Thomas R., Tangpricha, Vin, and Leonard, Michael K Jr
- Subjects
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TUBERCULOSIS , *LUNG diseases , *VITAMIN D , *CHEST X rays , *QUALITATIVE research - Abstract
Vitamin D regulates calcium homeostasis in the body and may play a major role in regulating immune responses to tuberculosis (TB). Pilot studies suggest that vitamin D supplementation may improve outcomes in pulmonary TB (PTB), but clinical evidence using vitamin D in TB treatment is limited. We present a case of vitamin D deficiency in a woman with refractory drug-susceptible PTB. Antituberculous therapy and the correction of vitamin D deficiency resulted in clinical and microbiologic improvement at month 13 of her treatment. The basis for vitamin D/TB interactions and a brief literature review are discussed. Data from controlled trials are needed to evaluate the efficacy of vitamin D as adjunctive TB therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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