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Your search keyword '"Otsuki, Makoto"' showing total 83 results
Start Over Author "Otsuki, Makoto" Publisher lippincott williams & wilkins
83 results on '"Otsuki, Makoto"'

7. Comparison of Glucagon and Scopolamine Butylbromide as Premedication for Colonoscopy in Unsedated Patients.

Author

Yoshikawa, Ichiro, Yamasaki, Masahiro, Taguchi, Masashi, Kanda, Kikuo, Tashiro, Mitsuo, Kume, Keiichiro, Tabaru, Akinari, and Otsuki, Makoto

Abstract

Premedication with glucagon or hyoscyamine is reported to be effective in reducing colonic spasm. However, these drugs can be associated with unfavorable events. This prospective study was designed to compare the effects of premedication with glucagon with those of scopolamine butylbromide on cardiopulmonary parameters, intubation time, and patient discomfort in unsedated patients undergoing diagnostic colonoscopy. One hundred consecutive adult patients (65 males) undergoing colonoscopy without sedation were randomized toreceive 1 mg of glucagon (n = 50) or 20 mg of scopolamine butylbromide (n = 50), intramuscularly. Physiologic changes, including systolic blood pressure, heart rate, and oxygen saturation, were monitored before colonoscope insertion and at three-minute intervals during colonoscopy. The percentages of completed procedure and time to cecal intubation were recorded. Patients were asked to rate pain by using a five-point pain score (0 = no pain; 4 = severe pain). The percentages of completed procedure (96 vs. 98 percent), time to cecal intubation (16.3 vs. 14.5 minutes), and pain score (1.7 vs. 1.5) did not differ significantly between two groups. An increase in heart rate of more than ten beats per minute from baseline during colonoscopy occurred significantly more often in scopolamine group (44 percent of 50 patients) than in the glucagon group (12 percent of 50 patients; P = 0.0004). There were no significant differences between the two study groups with regard to changes in systolic blood pressure and decrease in oxygen saturation during colonoscopy. Premedication with 1 mg of glucagon facilitates favorable examination with respect to physiologic changes compared with 20 mg of scopolamine. These features favor glucagon as the preferred premedication for patients undergoing colonoscopy. [ABSTRACT FROM AUTHOR]

Published
2006
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18. Ischemic Colitis Caused by Strict Dieting in an 18-Year-Old Female: Report of a Case.

Author

Shibata, Michihiko, Nakamura, Hayato, Abe, Shintaro, Kume, Keiichiro, Yoshikawa, Ichiro, Murata, Ikuo, and Otsuki, Makoto

Abstract

Ischemic colitis is typically limited to elderly patients who have concomitant disorders such as cardiovascular disease and chronic renal failure, but rarely affects a young person. The patient was an 18-year-old Japanese female who started dieting to obtain a slim figure three months before admission and presented with a two-month history of constipation and a sudden onset of lower abdominal pain and bloody diarrhea. She underwent colonoscopy, which revealed edema, hemorrhages, and several longitudinal shallow ulcers in the descending colon. Stool and blood culture results were negative for pathogens. She improved rapidly within five days without any specific therapies except intravenous hydration and anticholinergic agents, under the diagnosis of ischemic colitis. In this case constipation and dehydration associated with dieting seemed to be responsible for the development of ischemic colitis. We recommend that ischemic colitis should be included in the differential diagnosis of colitis with bleeding, even in patients younger than age 20 who do not have any predisposing factors. [ABSTRACT FROM AUTHOR]

Published
2002
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