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BACKGROUND VYC-12 is a novel hyaluronic acid-based dermal filler designed to treat fine lines and improve skin quality. A specialist digital camera and proprietary Digital Analysis of the Cutaneous Surface (DACS) software have previously been used to objectively measure changes in skin features. OBJECTIVE To assess the effect of facial treatment with VYC-12 on skin texture using the specialist camera. MATERIALS AND METHODS This was a prospective, open-label, 2-center study of 40 women aged 35 to 60 years treated with multiple, microdepot intradermal injections of VYC-12 (2 mL in the face; 1 mL in the neck if required). Eight patients (20.0%) required a touch-up at Day 45. Images were acquired using the specialist camera at baseline and 45 days and 6 months after treatment, and were analyzed by DACS. Clinical improvements were also assessed subjectively using the Global Aesthetic Improvement Scale (GAIS). RESULTS VYC-12 improved skin texture from baseline after 45 days (mean improvement: 25.9% 6 9.2%) and 6 months (mean improvement: 30.7% 6 18.2%). Improvements were also evident using the GAIS. There were no major adverse events. CONCLUSIONS VYC-12 improves skin quality, as measured using an objective, fast, and reproducible measuring tool. VYC-12 represents a valuable addition to the treatment armamentarium. [ABSTRACT FROM AUTHOR]