7 results on '"Plant Oils poisoning"'
Search Results
2. A poisoning of topical importance.
- Author
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Dreisinger N, Zane D, and Etwaru K
- Subjects
- Administration, Topical, Child, Preschool, Humans, Male, Consciousness Disorders chemically induced, Eucalyptus poisoning, Plant Oils poisoning
- Published
- 2006
- Full Text
- View/download PDF
Catalog
3. Acute lung injury after peppermint oil injection.
- Author
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Behrends M, Beiderlinden M, and Peters J
- Subjects
- Adolescent, Female, Humans, Injections, Intravenous, Mentha piperita, Plant Oils administration & dosage, Plant Oils poisoning, Pulmonary Edema chemically induced, Respiratory Distress Syndrome chemically induced
- Abstract
Unlabelled: We describe a case of acute lung injury following IV injection of peppermint oil. An 18-yr-old woman injected the oil and developed fulminant pulmonary edema requiring ventilator support. Within 4 h after injection her arterial oxygen tension was 8.1 kPa (60 mm Hg) at an inspired oxygen fraction (F(IO2)) of 0.7 (P/F ratio: 85) despite a positive end expiratory pressure (PEEP) of 20 mbar, therefore meeting criteria for acute respiratory distress syndrome (ARDS). Mean pulmonary artery pressures and pulmonary artery wedge pressures were within normal limits throughout the case (<25 mm Hg and <10 mm Hg, respectively). Ventilation with high PEEP and diuresis resulted in a P/F ratio of 265 after 24 h. The patient was successfully weaned from the ventilator on the 9th day. This report is the first description of the sequelae of IV peppermint oil injection. The injection resulted in pulmonary edema and acute lung injury, presumably due to direct toxicity and a resultant increase in pulmonary vascular permeability., Implications: This report is the first description of IV peppermint oil injection. The patient rapidly developed severe fluid overload of the lung and subsequent lung injury that required intubation, mechanical ventilation, and intensive care therapy for 13 days. The pulmonary edema was presumably caused by direct toxicity and an increase in pulmonary vascular permeability. more...
- Published
- 2005
- Full Text
- View/download PDF
4. Late deaths among young women affected by the toxic oil syndrome in Spain.
- Author
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Posada de la Paz M, Abaitua I, Terracini B, Giménez O, Sánchez-Porro P, and Gómez-Mera C
- Subjects
- Adult, Age Distribution, Disease Progression, Female, Humans, Population Surveillance, Registries, Sex Distribution, Spain epidemiology, Syndrome, Time Factors, Autoimmune Diseases etiology, Autoimmune Diseases mortality, Brassica, Plant Oils poisoning
- Published
- 1999
- Full Text
- View/download PDF
5. Epidemiologic evidence for a new class of compounds associated with toxic oil syndrome.
- Author
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Posada de la Paz M, Philen RM, Schurz H, Hill RH Jr, Giménez Ribota O, Gómez de la Camara A, Kilbourne EM, and Abaitua I
- Subjects
- Anilides analysis, Fatty Acids, Monounsaturated, Humans, Odds Ratio, Rapeseed Oil, Spain epidemiology, Syndrome, Brassica, Disease Outbreaks, Environmental Exposure, Plant Oils poisoning, Propylene Glycols analysis
- Abstract
Toxic oil syndrome appeared in epidemic form in Spain in 1981. Epidemiologic studies have demonstrated that illness was caused by consumption of rapeseed oil that had been denatured with aniline. Chemical analyses of oil specimens conducted in conjunction with epidemiologic studies have established that consumption of specific oils containing fatty acid anilide contaminants was associated with increased risk for disease. New chemical analytic methods identified a family of compounds, the di-fatty acid esters of phenylamino propane-diol, and one of these compounds, the 1,2-di-oleyl ester of 3-(N-phenylamino)-1,2-propanediol (DPAP), has been found to be more strongly associated with disease status than the fatty acid anilides. We found the odds ratio for exposure to DPAP (OR = 26.4, 95% CI = 6.4-76.3) is much higher than the odds ratio for exposure to oleyl anilide (OR = 4.1, 95% CI = 2.2-7.8), implying that exposure to DPAP was a more relevant risk factor for development of toxic oil syndrome than exposure to oleyl anilide. In this paper, we review and present analyses of data from multiple studies of the possible etiologic role of DPAP in toxic oil syndrome. The presence of DPAP in oil collected from affected and unaffected households was a more specific correlate of case relatedness than was the presence of fatty acid anilides, and it was equally sensitive. Moreover, DPAP was found in oil from the only refinery whose oil was clearly associated with illness. more...
- Published
- 1999
6. Factors associated with pathogenicity of oils related to the toxic oil syndrome epidemic in Spain.
- Author
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Posada de la Paz M, Philen RM, Abaitua Borda I, Diez Ruiz-Navarro M, Abraira Santos V, Pozo Rodríguez F, Pla Mestre R, Pollán Santamaría M, Sicilia Socias JM, and Azpeitia Gamazo P
- Subjects
- Disease Outbreaks, Fatty Acids, Monounsaturated, Food Contamination, Humans, Rapeseed Oil, Spain epidemiology, Aniline Compounds analysis, Brassica, Oleic Acids analysis, Plant Oils chemistry, Plant Oils poisoning
- Abstract
The toxic oil syndrome (TOS), which affected over 20,000 persons in Spain in 1981, has been linked to the consumption of aniline-denatured rapeseed oil, but the precise etiologic agent is still unknown. We attempted to validate the use of high concentrations of oleyl anilide as a marker for oils that contain (or contained) the causal agent. We compared the chemical compositions of oils obtained from ill (N = 59) and unaffected (N = 70) families in 1981. Case oils had higher concentrations of fatty acids and sterols in which rapeseed oil is particularly rich. In addition, case oils had more frequent and extensive contamination with oleyl anilide and other fatty acid anilides. We observed a dose-response effect; risk increased sharply with increasing concentrations of oleyl anilide, and no control oil had more than about 825 micrograms per liter of that compound. We conclude that high concentrations of oleyl anilide specifically mark oils that contain (or used to contain) the TOS etiologic agent. more...
- Published
- 1994
- Full Text
- View/download PDF
7. Toxic oil syndrome. A long-term follow-up of a cohort of 332 patients.
- Author
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Alonso-Ruiz A, Calabozo M, Perez-Ruiz F, and Mancebo L
- Subjects
- Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Cohort Studies, Fatty Acids, Monounsaturated, Female, Follow-Up Studies, Humans, Infant, Male, Middle Aged, Poisoning diagnosis, Poisoning therapy, Prognosis, Rapeseed Oil, Brassica, Plant Oils poisoning
- Abstract
Toxic oil syndrome is a multisystemic, epidemic disease that appeared in Spain in 1981, related to the intake of rapeseed cooking oil sold in bulk. It affected 19,748 people, of whom 457 died. The toxic substance was never identified. We report the 8-year follow-up of a cohort of 332 patients. The disease was usually severe and disabling during the first 2 years, but the clinical condition of most of the patients improved thereafter. The acute phase lasted 2 months, and was characterized by pulmonary edema, rash, eosinophilia, and myalgia. During the intermediate phase (second to fourth months), severe myalgia, skin tenderness, subcutaneous edema, altered liver function, and pulmonary hypertension developed. Later on, an early chronic phase developed, from the fourth month to the end of the second year. It was marked by scleroderma, sicca syndrome, polyneuropathy, joint contractures, weight loss, and functional limitations. The clinical manifestations improved during the late chronic phase. Its most prominent clinical features were muscle cramps, chronic musculoskeletal pain, chronic lung disease, Raynaud phenomenon, carpal tunnel syndrome, and psychologic disturbances. Only 9% of the patients achieved remission after the acute phase, the rest developing late clinical manifestations of the disease. The severity of the chronic manifestations was rather variable. At the end of the 8-year follow-up, there were 10 TOS-related deaths (3%), 47% of the patients had some kind of complaint, albeit subtle in most cases, and 16% showed organic involvement related to TOS. The most important pathologic features of TOS were widespread interstitial infiltrates, non-necrotizing angiitis, endothelial proliferation, and tissue fibrosis. Toxic oil syndrome is a dramatic example of an induced scleroderma-like syndrome, similar to the eosinophilia-myalgia syndrome. Patients with EMS may develop some of the late clinical features of TOS in the years to come. more...
- Published
- 1993
- Full Text
- View/download PDF
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