16 results on '"Probst, S."'
Search Results
2. Droperidol Causes a Dose-Dependent Prolongation of the QT Interval.
- Author
-
Lischke, V., Behne, M., Doelken, P., Schledt, U., Probst, S., and Vettermann, J.
- Published
- 1995
- Full Text
- View/download PDF
3. Prolongation of the QT-Wave Interval during Induction of Anesthesia in Patients with Coronary Artery Disease.
- Author
-
Lischke, V., Wilke, H-J., Probst, S., Behne, M., and Kessler, P.
- Published
- 1994
- Full Text
- View/download PDF
4. Nursing Students' Knowledge on Pressure Injuries Following a Blended-Learning Unit: A Quasi-experimental Study.
- Author
-
Bobbink P, Gschwind G, Charbonneau L, Guex C, Chabal L, and Probst S
- Subjects
- Humans, Clinical Competence, Pressure Ulcer etiology, Pressure Ulcer prevention & control, Students, Nursing
- Abstract
Objective: To assess first-year bachelor's degree in nursing students' knowledge about pressure injury (PI) etiology, classification, prevention, and management following blended learning and clinical practice., Methods: A quasi-experimental design was used. Nursing students' PI knowledge was measured using the French version of the Pressure Ulcer Knowledge Assessment Tool (PUKAT) at three time points: baseline (before a blended-learning unit, consisting of 2 hours of e-learning and 3 hours of practical workshop), after the blended-learning unit, and after clinical practice., Results: A total of 21 students participated over the three time points. At baseline, the mean percentage of correct answers on the PUKAT was 45.8%. This score increased to 59.2% following the blended-learning unit and 65% after completing the clinical practice (F2,58 = 19.08; P = .00). Over the three time points, students scored highest on knowledge of risk assessment and lowest on knowledge of prevention., Conclusions: Blended-learning units combining e-learning and practical workshops are valuable tools to increase students' knowledge about PIs. The PUKAT enables the evaluation of changes in students' knowledge following a teaching unit on PIs. However, more research is needed to assess the long-term evolution of knowledge and the impact of this teaching on clinical practice., (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2023
- Full Text
- View/download PDF
5. Comparing digital to analog prostate-specific membrane antigen-targeted piflufolastat 18 F PET/CT in prostate cancer patients in early biochemical failure.
- Author
-
Maliha PG, Nolet B, Ebrahim A, Abikhzer G, Chaussé G, Bahoric B, Niazi T, and Probst S
- Subjects
- Humans, Male, Gallium Radioisotopes, Lysine, Positron Emission Tomography Computed Tomography methods, Positron-Emission Tomography, Prostate pathology, Radiopharmaceuticals, Retrospective Studies, Prostate-Specific Antigen, Prostatic Neoplasms pathology
- Abstract
Purpose: Prostate-specific membrane antigen (PSMA) positron emission tomography/computer tomography (PET/CT) in prostate cancer patients with biochemical failure(BCF) showslimited sensitivity when the prostate-specific antigen(PSA) <0.5 ng/mL. The development of digital PET/CT has greatly improved smaller lesion detection. This study's goal was to compare the performance and clinical value of PSMA-targeted piflufolastat PET/CT for prostate cancer BCF with digital versus analog PET/CT., Methods: In this retrospective study, all piflufolastat PET/CT scans in subjects with PSA ≤ 3.0 ng/mL who were referred for prostate cancer BCF were included. The performance characteristics of 171 analog PET/CT studies in 155 subjects from May 2017 to January 2020 and 106 digital PET/CT studies in 103 subjects from February 2020 to December 2020 were compared. Lesions were considered malignant if they did not match the known physiological distribution of piflufolastat and did not represent uptake in benign lesions. PSMA PET/CT studies were considered positive if at least one malignant lesion was detected and negative if none were detected., Results: Digital piflufolastat PET/CT outperformed analog piflufolastat PET/CT in subjects with PSA < 0.5 ng/mL with a positivity rate of 69% versus 37%, respectively. In patients with PSA ≥ 0.5 ng/mL, both technologies performed similarly. There was no statistically significant difference between the number or size of piflufolastat-avid lesions detected per PET/CT study., Conclusion: In prostate cancer patients with BCF and PSA < 0.5 ng/mL, digital piflufolastat PET/CT has a higher detection rate of malignant lesions than analog piflufolastat PET/CT., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
6. Physiologic prostate-specific membrane antigen-targeted 18F-DCFPyL uptake in the epididymis head newly appreciated on digital PET/CT.
- Author
-
Maliha PG, Singerman J, Abikhzer G, and Probst S
- Subjects
- Male, Humans, Aged, Middle Aged, Retrospective Studies, Biological Transport, Aged, 80 and over, Positron Emission Tomography Computed Tomography, Antigens, Surface metabolism, Epididymis diagnostic imaging, Epididymis metabolism, Glutamate Carboxypeptidase II metabolism, Lysine analogs & derivatives, Lysine metabolism, Urea analogs & derivatives, Urea metabolism
- Abstract
Purpose: The published physiological distribution of prostate specific membrane antigen (PSMA) PET ligands includes normal uptake in the lacrimal glands, salivary glands, bowel, liver, spleen, kidneys and parasympathetic ganglia but does not include the epididymis., Methods: Retrospective review of 134 PSMA-targeted 2-(3-(1-carboxy-5-[(6-[18F]fluoropyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid (18F-DCFPyL) PET/CT scans performed on a latest generation digital scanner for radiotracer uptake in the epididymal head region was correlated with multiple clinical and laboratory factors., Results: Physiologic PSMA radiotracer uptake in the epididymal head region was present in 57% of all subjects, including 29% in those with a total serum testosterone ≤ 5 nmol/L and 65% of patients with serum testosterone > 5 nmol/L, odds ratio of 0.21 (P < 0.01)., Conclusion: Epididymal head uptake is physiologic and very common on digital PSMA PET/CT and is more frequent in patients with higher serum testosterone levels. The enhanced small structure detection of digital PET/CT is the most likely explanation for the novel visualization of this normal variant., (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
7. Weight loss as primary indication for FDG-PET/CT.
- Author
-
Maliha PG, Singerman J, and Probst S
- Subjects
- Adult, Aged, False Positive Reactions, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasms diagnostic imaging, Neoplasms pathology, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Weight Loss
- Abstract
Purpose: Some consider fluorodeoxyglucose positron emission tomography with computed tomography (FDG-PET/CT) clinically useful in patients presenting with nonspecific symptoms of malignancy, weight loss most commonly encountered. However, the appropriateness of such FDG-PET/CT studies remains to be clarified. This study evaluated the clinical value of FDG-PET/CT in patients referred primarily for weight loss., Methods: From 2010 to 2017 in one academic center, 252 subjects underwent 254 FDG-PET/CT studies for weight loss as primary indication and retrospectively studied. Eighteen subjects were excluded due to ongoing active malignancy, weight loss not ultimately being the main indication for the FDG-PET/CT, technically inadequate FDG-PET/CT and insufficient follow-up. The FDG-PET/CT scans were considered clinically beneficial when true positive for the cause of weight loss that other investigations missed or would have missed, clinically neutral when true negative and clinically detrimental when false positive leading to additional investigations or false negative., Results: Ultimately 234 unique subjects (236 FDG-PET/CT studies) were included. The average subject weight loss prior to the PET was 12 kg and average follow-up time post FDG-PET/CT scan was 3.4 years. The FDG-PET/CT scans were true positive in 24 studies (10%) with 8 studies (3%) clinically beneficial; false positive in 38 studies (16%) of which 26 led to 35 additional procedures and false negative in 13 studies (6%). In total, 39 (17%) FDG-PET/CT studies were clinically detrimental. The other 149 (63%) studies were true negative, clinically neutral., Conclusion: FDG-PET/CT appears to have limited value in assessing subjects with weight loss as the leading clinical indication, proving to be five times more often detrimental than beneficial.
- Published
- 2020
- Full Text
- View/download PDF
8. 18F-FDG PET/CT versus conventional investigations for cancer screening in autoimmune inflammatory myopathy in the era of novel myopathy classifications.
- Author
-
Maliha PG, Hudson M, Abikhzer G, Singerman J, and Probst S
- Subjects
- Aged, Autoimmune Diseases classification, Cohort Studies, Early Detection of Cancer, Female, Humans, Inflammation complications, Male, Middle Aged, Muscular Diseases classification, Retrospective Studies, Autoimmune Diseases complications, Fluorodeoxyglucose F18, Mass Screening methods, Muscular Diseases complications, Neoplasms complications, Neoplasms diagnostic imaging, Positron Emission Tomography Computed Tomography
- Abstract
Background: To compare the performance of fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) and conventional tests for cancer screening in autoimmune inflammatory myopathy (AIM) patients., Patients and Methods: We carried out a retrospective cohort study of AIM patients from one academic center in Montreal, Canada, classified using myositis-specific antibodies, who underwent F-FDG PET/CT between April 2005 and February 2018 and were followed up on average 3.5±2.4 years. Patients were excluded if follow-up was insufficient, AIM diagnosis was indeterminate, and/or malignancy was diagnosed before an F-FDG PET/CT scan. Demographic/clinical data, F-FDG PET/CT results, and available conventional screening tests results were retrieved from electronic and paper medical records., Results: 100 F-FDG PET/CT studies in 63 unique patients [31/63 dermatomyositis (DM), 25/63 overlap myositis, 1/63 inclusion body myositis, 1/63 polymyositis, 1/63 orbital myositis and 4/63 unspecified myositis] were evaluated. Three patients, all classified as DM, were diagnosed with cancer during follow-up with conventional cancer screening tests: breast cancer detected by mammography; squamous cell carcinoma of the skin detected by physical examination; and multiple myeloma detected by blood work. F-FDG PET/CT did not detect any malignancy and led to more additional biopsies than conventional screening (8 vs. 5)., Conclusion: F-FDG PET/CT does not appear to be useful in cancer screening for AIM patients compared with conventional screening and carries potential harms associated with follow-up investigations. The risk of cancer in AIM differs by myositis-specific antibodies-defined subsets and cancer screening is likely to be indicated only in high-risk patients, particularly DM. These results, replicated in larger, multicentered studies, may carry significant consequences for optimal management of AIM and health resource utilization.
- Published
- 2019
- Full Text
- View/download PDF
9. Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane.
- Author
-
Benveniste H, Lee H, Ding F, Sun Q, Al-Bizri E, Makaryus R, Probst S, Nedergaard M, Stein EA, and Lu H
- Subjects
- Amyloid beta-Peptides metabolism, Anesthetics, Inhalation administration & dosage, Animals, Biological Transport drug effects, Biological Transport physiology, Cerebrovascular Circulation drug effects, Cerebrovascular Circulation physiology, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Hippocampus diagnostic imaging, Hypnotics and Sedatives administration & dosage, Isoenzymes metabolism, L-Lactate Dehydrogenase metabolism, Magnetic Resonance Imaging methods, Rats, Rats, Inbred F344, Signal Transduction physiology, Dexmedetomidine administration & dosage, Gadolinium DTPA metabolism, Hippocampus drug effects, Hippocampus metabolism, Isoflurane administration & dosage, Signal Transduction drug effects
- Abstract
Background: The glymphatic pathway transports cerebrospinal fluid through the brain, thereby facilitating waste removal. A unique aspect of this pathway is that its function depends on the state of consciousness of the brain and is associated with norepinephrine activity. A current view is that all anesthetics will increase glymphatic transport by inducing unconsciousness. This view implies that the effect of anesthetics on glymphatic transport should be independent of their mechanism of action, as long as they induce unconsciousness. We tested this hypothesis by comparing the supplementary effect of dexmedetomidine, which lowers norepinephrine, with isoflurane only, which does not., Methods: Female rats were anesthetized with either isoflurane (N = 8) or dexmedetomidine plus low-dose isoflurane (N = 8). Physiologic parameters were recorded continuously. Glymphatic transport was quantified by contrast-enhanced magnetic resonance imaging. Cerebrospinal fluid and gray and white matter volumes were quantified from T1 maps, and blood vessel diameters were extracted from time-of-flight magnetic resonance angiograms. Electroencephalograms were recorded in separate groups of rats., Results: Glymphatic transport was enhanced by 32% in rats anesthetized with dexmedetomidine plus low-dose isoflurane when compared with isoflurane. In the hippocampus, glymphatic clearance was sixfold more efficient during dexmedetomidine plus low-dose isoflurane anesthesia when compared with isoflurane. The respiratory and blood gas status was comparable in rats anesthetized with the two different anesthesia regimens. In the dexmedetomidine plus low-dose isoflurane rats, spindle oscillations (9 to 15 Hz) could be observed but not in isoflurane anesthetized rats., Conclusions: We propose that anesthetics affect the glymphatic pathway transport not simply by inducing unconsciousness but also by additional mechanisms, one of which is the repression of norepinephrine release.
- Published
- 2017
- Full Text
- View/download PDF
10. How are topical opioids used to manage painful cutaneous lesions in palliative care? A critical review.
- Author
-
Graham T, Grocott P, Probst S, Wanklyn S, Dawson J, and Gethin G
- Subjects
- Administration, Topical, Humans, Pain diagnosis, Randomized Controlled Trials as Topic methods, Skin Ulcer diagnosis, Analgesics, Opioid administration & dosage, Pain drug therapy, Pain Management methods, Palliative Care methods, Skin Ulcer drug therapy
- Published
- 2013
- Full Text
- View/download PDF
11. Malignant wound management in advanced illness: new insights.
- Author
-
Grocott P, Gethin G, and Probst S
- Subjects
- Hemorrhage drug therapy, Hemorrhage etiology, Hemorrhage psychology, Humans, Skin Neoplasms drug therapy, Skin Neoplasms psychology, Terminally Ill, Wounds and Injuries complications, Wounds and Injuries etiology, Wounds and Injuries psychology, Electrochemotherapy, Odorants prevention & control, Palliative Care methods, Skin Neoplasms complications, Wound Healing, Wounds and Injuries drug therapy
- Abstract
Purpose of Review: This article describes why this review is timely and relevant. To report on the recent research, which advances our understanding and practice of palliative wound care (wound-related pain and symptom management or wound palliation)., Recent Findings: This article describes the main themes in the literature covered by the article. The main themes include the problem of malodour and the palliative management of cutaneous and subcutaneous malignancy of skin and nonskin origins. The findings from an international survey of measures to combat wound malodour are reported, which indicate that malodour is one of the most distressing and difficult to manage symptoms associated with malignant wounds. A relatively novel palliative treatment for cutaneous malignancy, electrochemotherapy, is outlined, together with the growing evidence supporting its use., Summary: This article describes the implications of the findings for clinical practice or research. The findings of the wound malodour survey indicate that approaches to managing malodour are wide ranging, but ineffective. Collaborate research and development is needed with industry into interventions to combat malodour, which are based on the causal agents. The growing evidence of the effectiveness of electrochemotherapy, as an uncomplicated palliative treatment and method of managing symptoms, offers palliative care clinicians a means of managing the otherwise relentless progression of cutaneous malignancy.
- Published
- 2013
- Full Text
- View/download PDF
12. Sarcomere gene mutations in isolated left ventricular noncompaction cardiomyopathy do not predict clinical phenotype.
- Author
-
Probst S, Oechslin E, Schuler P, Greutmann M, Boyé P, Knirsch W, Berger F, Thierfelder L, Jenni R, and Klaassen S
- Subjects
- Cohort Studies, DNA Mutational Analysis, Humans, Pedigree, Penetrance, Phenotype, Cardiomyopathies genetics, Carrier Proteins genetics, Mutation, Sarcomeres genetics, Tropomyosin genetics, Ventricular Dysfunction, Left
- Abstract
Background: Left ventricular noncompaction of the myocardium (LVNC) has been recognized as a cardiomyopathy with a genetic etiology. Mutations in genes encoding sarcomere proteins were shown to be associated with LVNC. We evaluated the potential clinical impact of genetic analysis of sarcomere genes in patients with LVNC., Methods and Results: We identified 5 mutations in cardiac myosin-binding protein C (MYBPC3) and 2 mutations in α-tropomyosin (TPM1) in a cohort of unrelated adult probands with isolated LVNC. The mutations in MYBPC3 and TPM1 and in 6 other previously reported sarcomere genes in this cohort resulted in a total of 18 (29%) heterozygous mutations in 63 probands. β-myosin heavy chain (MYH7) was the most prevalent disease gene and accounts for 13% of cases, followed by MYBPC3 (8%). Comparing sarcomere mutation-positive and mutation-negative LVNC probands showed no significant differences in terms of average age, myocardial function, and presence of heart failure or tachyarrhythmias at initial presentation or at follow-up. Familial disease was found in 16 probands of whom 8 were sarcomere mutation positive. Nonpenetrance was detected in 2 of 8 mutation-positive families with LVNC., Conclusions: Mutations in sarcomere genes account for a significant (29%) proportion of cases of isolated LVNC in this cohort. The distribution of disease genes confirms genetic heterogeneity and opens new perspectives in genetic testing in patients with LVNC and their relatives at high risk of inheriting the cardiomyopathy. The presence or absence of a sarcomere gene mutation in LVNC cannot be related to the clinical phenotype.
- Published
- 2011
- Full Text
- View/download PDF
13. Mutations in the sarcomere gene MYH7 in Ebstein anomaly.
- Author
-
Postma AV, van Engelen K, van de Meerakker J, Rahman T, Probst S, Baars MJ, Bauer U, Pickardt T, Sperling SR, Berger F, Moorman AF, Mulder BJ, Thierfelder L, Keavney B, Goodship J, and Klaassen S
- Subjects
- Adolescent, Adult, Aged, Amino Acid Sequence, Cardiac Myosins chemistry, Child, Child, Preschool, Cohort Studies, Ebstein Anomaly diagnostic imaging, Family, Female, Humans, Infant, Male, Middle Aged, Molecular Sequence Data, Myosin Heavy Chains chemistry, Pedigree, Ultrasonography, Young Adult, Cardiac Myosins genetics, Ebstein Anomaly genetics, Mutation genetics, Myosin Heavy Chains genetics, Sarcomeres genetics
- Abstract
Background: Ebstein anomaly is a rare congenital heart malformation characterized by adherence of the septal and posterior leaflets of the tricuspid valve to the underlying myocardium. An association between Ebstein anomaly with left ventricular noncompaction (LVNC) and mutations in MYH7 encoding β-myosin heavy chain has been shown; in this report, we have screened for MYH7 mutations in a cohort of probands with Ebstein anomaly in a large population-based study., Methods and Results: Mutational analysis in a cohort of 141 unrelated probands with Ebstein anomaly was performed by next-generation sequencing and direct DNA sequencing of MYH7. Heterozygous mutations were identified in 8 of 141 samples (6%). Seven distinct mutations were found; 5 were novel and 2 were known to cause hypertrophic cardiomyopathy. All mutations except for 1 3-bp deletion were missense mutations; 1 was a de novo change. Mutation-positive probands and family members showed various congenital heart malformations as well as LVNC. Among 8 mutation-positive probands, 6 had LVNC, whereas among 133 mutation-negative probands, none had LVNC. The frequency of MYH7 mutations was significantly different between probands with and without LVNC accompanying Ebstein anomaly (P<0.0001). LVNC segregated with the MYH7 mutation in the pedigrees of 3 of the probands, 1 of which also included another individual with Ebstein anomaly., Conclusions: Ebstein anomaly is a congenital heart malformation that is associated with mutations in MYH7. MYH7 mutations are predominantly found in Ebstein anomaly associated with LVNC and may warrant genetic testing and family evaluation in this subset of patients.
- Published
- 2011
- Full Text
- View/download PDF
14. Novel gene locus for autosomal dominant left ventricular noncompaction maps to chromosome 11p15.
- Author
-
Sasse-Klaassen S, Probst S, Gerull B, Oechslin E, Nürnberg P, Heuser A, Jenni R, Hennies HC, and Thierfelder L
- Subjects
- Adolescent, Chromosome Mapping, DNA-Binding Proteins genetics, Female, Genes, Dominant, Haplotypes, High Mobility Group Proteins genetics, Humans, LIM Domain Proteins, Lod Score, Male, Muscle Proteins genetics, Mutation, Pedigree, SOXD Transcription Factors, Transcription Factors genetics, Cardiomyopathies genetics, Chromosomes, Human, Pair 11
- Abstract
Background: Left ventricular noncompaction (LVNC) is a congenital unclassified cardiomyopathy with numerous prominent trabeculations and deep intertrabecular recesses in a hypertrophied and hypokinetic myocardium. It has been reported to occur in isolation or in association with congenital heart disease. Mutations in the X-linked G4.5 gene are responsible for cases of isolated LVNC in male infants, but G4.5 mutations were not found in patients with clinical onset of disease in adulthood. In addition, several families with LVNC and an autosomal dominant pattern of inheritance suggest genetic heterogeneity., Methods and Results: We performed a genome-wide linkage analysis in a family with autosomal dominant LVNC and show that a locus containing the LVNC disease gene maps to chromosome 11p15. A peak 2-point logarithm of odds score of 5.06 was obtained with marker D11S902 at theta=0. Haplotype analysis defined a critical interval of 6.4 centimorgan between D11S1794 and D11S928 corresponding to a physical distance of 6.8 megabases. No disease-causing mutation was identified in 2 prime positional candidate genes, muscle LIM protein (MLP) and SOX6., Conclusions: We have mapped a locus for autosomal dominant LVNC to a 6.8-megabase region on human chromosome 11p15. Identification of the disease gene will allow genetic screening and provide fundamental insight into the understanding of myocardial morphogenesis.
- Published
- 2004
- Full Text
- View/download PDF
15. Droperidol causes a dose-dependent prolongation of the QT interval.
- Author
-
Lischke V, Behne M, Doelken P, Schledt U, Probst S, and Vettermann J
- Subjects
- Blood Pressure drug effects, Dose-Response Relationship, Drug, Heart Rate drug effects, Humans, Prospective Studies, Droperidol pharmacology, Electrocardiography drug effects
- Abstract
To further investigate possible prolongation of the frequency-corrected QT interval (QTc interval) after administration of droperidol (DRO), we studied 40 surgical patients who were randomly assigned to one of three groups, receiving an intravenous (IV) injection of either 0.1 mg/kg (Group 1, n = 10), 0.175 mg/kg (Group 2, n = 10), or 0.25 mg/kg (Group 3, n = 20) of DRO at induction of anesthesia. The QTc interval, heart rate, and arterial pressure were registered before and 1, 2, 3, 4, 5, 7.5, and 10 min after the respective dose injection. Significant prolongations of the median QTc interval were found in patients from all groups, ranging from 37 ms (8.0%) in Group 1, to 44 ms (10.6%) in Group 2, to 59 ms (14.9%) in Group 3, when compared with control. The heart rate showed a significant increase in all groups. Mean arterial pressure (MAP) was slightly but significantly decreased in Groups 1 and 3. Prolongation of the QTc interval is a predictable and dose-dependent side effect after injection of high-dose DRO.
- Published
- 1994
- Full Text
- View/download PDF
16. Reversal by nalbuphine of respiratory depression caused by fentanyl.
- Author
-
Latasch L, Probst S, and Dudziak R
- Subjects
- Adult, Blood Gas Analysis, Blood Pressure, Female, Fentanyl pharmacology, Heart Rate, Humans, Male, Middle Aged, Pain, Postoperative drug therapy, Postoperative Period, Tidal Volume, Fentanyl antagonists & inhibitors, Morphinans pharmacology, Nalbuphine pharmacology, Respiration drug effects
- Abstract
In 60 ASA class I or II patients given intravenous fentanyl for elective operations in doses large enough to produce postoperative respiratory depression, the intravenous administration of 20 mg nalbuphine resulted in prompt reversal of respiratory depression without loss of analgesia.
- Published
- 1984
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.