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88 results on '"Protogerou, A"'

1. Twelve hot questions in the management of hypertension in patients aged 80+ years and their answers with the help of the 2023 European Society of Hypertension Guidelines.

Author

Bahat, Gulistan, Ribeiro, Heloisa, Sheppard, James P., Bogaerts, Jonathan M. K., Camafort, Miguel, Dallmeier, Dhayana, De Backer, Tine, Desideri, Giovambattista, Olszanecka, Agnieszka, Persu, Alexandre, Protogerou, Athanase, Rajzer, Marek, Virdis, Agostino, Ungar, Andrea, Weber, Thomas, and Benetos, Athanase

Published
2024
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2. Differential Effects of Mean and Pulse Pressure on Stroke Risk

Author

Georgakis, Marios K., Gill, Dipender, Malik, Rainer, Protogerou, Athanase D., Webb, Alastair J.S., and Dichgans, Martin

Subjects
Adult, Male, Aging, hypertension, Mendelian randomization analysis, Genetic Variation, Blood Pressure, Original Articles, Arteries, Organ Size, Risk Assessment, United Kingdom, Stroke, Databases, Genetic, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Genetics, Humans, Female, Arterial Pressure, Genetic Predisposition to Disease, ddc:610, Genome-Wide Association Study, Aged
Abstract

Supplemental Digital Content is available in the text., Hypertension is the leading risk factor for stroke. Yet, it remains unknown whether blood pressure pulsatility (pulse pressure [PP]) causally affects stroke risk independently of the steady pressure component (mean arterial pressure [MAP]). It is further unknown how the effects of MAP and PP on stroke risk vary with age and stroke cause. Using data from UK Biobank (N=408 228; 38–71 years), we selected genetic variants as instruments for MAP and PP at age ≤55 and >55 years and across age deciles. We applied multivariable Mendelian randomization analyses to explore associations with ischemic stroke, intracerebral hemorrhage, and their subtypes. Higher genetically predicted MAP was associated with higher risk of ischemic stroke and intracerebral hemorrhage across the examined age spectrum. Independent of MAP, higher genetically predicted PP only at age >55 years was further associated with higher risk of ischemic stroke (odds ratio per-SD-increment, 1.23 [95% CI, 1.13–1.34]). Among subtypes, the effect of genetically predicted MAP on large artery stroke was attenuated, whereas the effect of genetically predicted PP was augmented with increasing age. Genetically predicted MAP, but not PP, was associated with small vessel stroke and deep intracerebral hemorrhage homogeneously across age deciles. Neither genetically predicted MAP nor PP were associated with lobar intracerebral hemorrhage. Beyond an effect of high MAP at any age on ischemic and hemorrhagic stroke, our results support an independent causal effect of high PP at older ages on large artery stroke. This finding warrants further investigation for the development of stroke preventive strategies targeting pulsatility in later life.

Published
2020
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4. Association of Pressure Wave Reflections With Left Ventricular Mass: a Systematic Review and Meta-Analysis.

Author

Yofoglu, Lazaros K., Karachalias, Fotios, Georgakis, Marios K., Tountas, Christos, Argyris, Antonios A., Zhang, Yi, Papaioannou, Theodoros G., Blacher, Jacques, Weber, Thomas, Vlachopoulos, Charalampos, Safar, Michel, and Protogerou, Athanase D.

Abstract

Background: Pressure wave reflections (PWRs) within the circulation are assessed at various arterial sites by various noninvasive methods. We aimed at reviewing the conflicting data regarding the hypothesis that higher PWRs are associated with higher left ventricular mass and tested whether this association stands for all available indices of PWRs, all (proximal or distal to the heart) sites of assessment, and is modified by sex, age and heart rate. Methods: Based on a predefined protocol applying the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines, we identified eligible for meta-analysis data regarding: augmentation index, augmentation pressure, backward pressure (Pb), reflection index, and their association with left ventricular mass index (19 studies, total population n=8686). Results: We found statistically significant associations, independent from blood pressure level, for all indices of PWRs at all arterial sites (carotid augmentation index; odds ratio; standardized beta coefficient [β]: 0.14 [95% CI, 0.07% to 0.21%], per SD increase), radial augmentation index (β: 0.21; 0.11 to 0.31), central augmentation pressure (β: 0.15; 0.03 to 0.27), central Pb (β: 0.23; 0.05 to 0.42), and central reflection index (β: 0.14; 0.06 to 0.22), except for aortic augmentation index as estimated by generalized transfer functions. Meta-regression analysis showed that the association between carotid augmentation index and left ventricular mass was higher among populations with higher heart rate (P =0.036, beta: 0.017 [95% CI, 0.001 to 0.033]) and tended to be higher in middle-aged (P =0.07, beta: −0.001; −0.021 to 0.001). Conclusions: A clinically meaningful association between PWRs and left ventricular mass, assessed at either central or peripheral arterial sites by most available methods was shown, suggesting that PWR reduction strategies might be useful. Based on the present evidence, such trials should target middle-aged populations with high normal heart rate. [ABSTRACT FROM AUTHOR]

Published
2023
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7. 24-HOUR CENTRAL BLOOD PRESSURE: REFERENCE VALUES FOR HEALTHY INDIVIDUALS. THE INTERNATIONAL 24HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)

Author

Weber, T, Protogerou, A, Wassertheurer, S, Agharazii, M, Argyris, A, Bahous, S, Banegas, J, Blacher, J, Brandao, A, Cruz, J, Giannattasio, C, Jankowski, P, Li, Y, Maloberti, A, Mcdonnel, B, Mceniery, C, Mota Gomes, M, Machado Gomes, A, Graciani, A, Muiesan, M, Nemcsik, J, Rodilla, E, Schutte, A, Terentes-Printzios, D, Vallee, A, Vlachopoulos, C, Ware, L, Wilkinson, I, Zweiker, R, Sharman., J, T. Weber, A. Protogerou, S. Wassertheurer, M. Agharazii, A. Argyris, S. A. Bahous, J. R. Banegas, J. Blacher, A. A. Brandao, J. J. Cruz, C. Giannattasio, P. Jankowski, Y. Li, A. Maloberti, B. McDonnel, C. McEniery, M. A. Mota Gomes, A. Machado Gomes, A. Graciani, M. L. Muiesan, J. Nemcsik, E. Rodilla, A. Schutte, D. Terentes-Printzios, A. Vallee, C. Vlachopoulos, L. Ware, I. Wilkinson, R. Zweiker, J. Sharman., Weber, T, Protogerou, A, Wassertheurer, S, Agharazii, M, Argyris, A, Bahous, S, Banegas, J, Blacher, J, Brandao, A, Cruz, J, Giannattasio, C, Jankowski, P, Li, Y, Maloberti, A, Mcdonnel, B, Mceniery, C, Mota Gomes, M, Machado Gomes, A, Graciani, A, Muiesan, M, Nemcsik, J, Rodilla, E, Schutte, A, Terentes-Printzios, D, Vallee, A, Vlachopoulos, C, Ware, L, Wilkinson, I, Zweiker, R, Sharman., J, T. Weber, A. Protogerou, S. Wassertheurer, M. Agharazii, A. Argyris, S. A. Bahous, J. R. Banegas, J. Blacher, A. A. Brandao, J. J. Cruz, C. Giannattasio, P. Jankowski, Y. Li, A. Maloberti, B. McDonnel, C. McEniery, M. A. Mota Gomes, A. Machado Gomes, A. Graciani, M. L. Muiesan, J. Nemcsik, E. Rodilla, A. Schutte, D. Terentes-Printzios, A. Vallee, C. Vlachopoulos, L. Ware, I. Wilkinson, R. Zweiker, and J. Sharman.

Published
2019

9. STUDY OF THE EUROPEAN SOCIETY OF HYPERTENSION ON BLOOD PRESSURE CONTROL IN ESH EXCELLENCE CENTERS (BP CON ESH) - THE FIRST PRELIMINARY REPORT

Author

Jelakovic, B, Triantafyllou, A, Doumas, M, Kalaitzidis, R, Protogerou, A, Kallistratos, E, Stergiou, G, Moloberti, A, Giannattasio, C, Marketou, M, Papadakis, I, Papadopoulos, D, Pengo, M, Parati, G, Sarafidis, P, Stojanov, V, Triantafyllidi, E, Manta, E, Tsioufis, K, Agabiti-Rosei, E, Kreutz, R, Polonia, J, Januszewicz, A, Mancia, G, Jelakovic, B, Triantafyllou, A, Doumas, M, Kalaitzidis, R, Protogerou, A, Kallistratos, E, Stergiou, G, Moloberti, A, Giannattasio, C, Marketou, M, Papadakis, I, Papadopoulos, D, Pengo, M, Parati, G, Sarafidis, P, Stojanov, V, Triantafyllidi, E, Manta, E, Tsioufis, K, Agabiti-Rosei, E, Kreutz, R, Polonia, J, Januszewicz, A, and Mancia, G

Published
2021

10. Superiority of 24-Hour Aortic Over 24-Hour Brachial Pressure to Associate With Carotid Arterial Damage on the Basis of Pressure Amplification Variability: the SAFAR Study.

Author

Argyris, Antonios A., Mouziouras, Dimitrios, Samara, Stamatia, Zhang, Yi, Georgakis, Marios K., Blacher, Jacques, Safar, Michel, Sfikakis, Petros P., and Protogerou, Athanase D.

Abstract

Background: Evidence suggests marginal superiority of static aortic systolic blood pressure (aSBP) compared with brachial SBP (bSBP) regarding the association with organ damage and prognosis of cardiovascular disease (CVD). The noninvasive 24-hour aSBP assessment is feasible and associates better with presence of left ventricular hypertrophy compared with 24-hour bSBP. We aimed at comparing the association of 24-hour aSBP and 24-hour bSBP with indices of arterial damage and examining the role of 24-hour SBP amplification variability (within-subjects' SD) in this association.Methods: Consecutive subjects referred for CVD risk assessment underwent 24-hour aortic and brachial ambulatory BP monitoring using a validated oscillometric device (Mobil-O-Graph). Arterial damage was assessed by carotid intima-media thickness (IMT) and detection of carotid and femoral atheromatosis (plaque presence).Results: Cross-sectionally 501 individuals (aged 54±13 years, 57% men, 80% hypertensives) were examined. Multivariable analysis revealed superiority of 24-hour aSBP regarding the association with IMT, carotid hypertrophy and carotid-but not femoral-atheromatosis. In receiver operator characteristics analysis, 24-hour aSBP displayed a higher discriminatory ability-compared to 24-hour bSBP-for the detection of both carotid hypertrophy (area under the curve, 0.662 versus 0.624, P<0.05) and carotid atheromatosis (area under the curve, 0.573 versus 0.547, P<0.05). This effect was more prominent in individuals with above-median 24-hour SD of SBP amplification.Conclusions: Our results suggest that 24-hour aSBP assessment may be of significant value in clinical practice to detect site-specific arterial damage on the basis of pressure amplification variability and should be prospectively examined in clinical trials. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Michel Emile Safar 1937 to 2024.

Author

Blacher, Jacques, Benetos, Athanase, Protogerou, Athanase D., Struijker-Boudier, Harry, and Levy, Bernard I.

Abstract

Michel Emile Safar, a renowned medical professional, passed away on January 28, 2024, at the age of 86. Born in Algiers in 1937, Safar began his medical studies in Paris in the early 1950s and went on to become a respected professor of internal medicine and therapeutics. Throughout his career, Safar focused on arterial hemodynamics and made significant contributions to the understanding of factors that regulate arterial pressure. His work emphasized the importance of pulse pressure in the prognosis of hypertensive patients, particularly older individuals. Safar was not only an exceptional scientist but also a compassionate and respected mentor to many physicians and researchers. He will be greatly missed. [Extracted from the article]

Published
2024
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15. Twenty-Four-Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals.

Author

Weber, Thomas, Protogerou, Athanase D., Agharazii, Mohsen, Argyris, Antonis, Aoun Bahous, Sola, Banegas, Jose R., Binder, Ronald K., Blacher, Jacques, Araujo Brandao, Andréa, Cruz, Juan J., Danninger, Kathrin, Giannatasio, Cristina, Graciani, Auxiliadora, Hametner, Bernhard, Jankowski, Piotr, Li, Yan, Maloberti, Alessandro, Mayer, Christopher C., McDonnell, Barry J., and McEniery, Carmel M.

Abstract

Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18-94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBPMAP/DBPcal), or bSBP/diastolic blood pressure (cSBPSBP/DBPcal), and a validated transfer function, resulting in 144 509 valid brachial and 130 804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBPMAP/DBPcal were 128, 128, and 125 mm Hg and 115, 117, and 107 mm Hg for cSBPSBP/DBPcal, respectively. We pragmatically propose as upper normal limit for 24-hour cSBPMAP/DBPcal 135 mm Hg and for 24-hour cSBPSBP/DBPcal 120 mm Hg. bSBP dipping (nighttime-daytime/daytime SBP) was -10.6 % in young participants and decreased with increasing age. Central SBPSBP/DBPcal dipping was less pronounced (-8.7% in young participants). In contrast, cSBPMAP/DBPcal dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation. [ABSTRACT FROM AUTHOR]

Published
2022
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17. Genetically Predicted Blood Pressure Across the Lifespan: Differential Effects of Mean and Pulse Pressure on Stroke Risk.

Author

Georgakis, Marios K., Gill, Dipender, Malik, Rainer, Protogerou, Athanase D., Webb, Alastair J.S., and Dichgans, Martin

Abstract

Hypertension is the leading risk factor for stroke. Yet, it remains unknown whether blood pressure pulsatility (pulse pressure [PP]) causally affects stroke risk independently of the steady pressure component (mean arterial pressure [MAP]). It is further unknown how the effects of MAP and PP on stroke risk vary with age and stroke cause. Using data from UK Biobank (N=408 228; 38-71 years), we selected genetic variants as instruments for MAP and PP at age ≤55 and >55 years and across age deciles. We applied multivariable Mendelian randomization analyses to explore associations with ischemic stroke, intracerebral hemorrhage, and their subtypes. Higher genetically predicted MAP was associated with higher risk of ischemic stroke and intracerebral hemorrhage across the examined age spectrum. Independent of MAP, higher genetically predicted PP only at age >55 years was further associated with higher risk of ischemic stroke (odds ratio per-SD-increment, 1.23 [95% CI, 1.13-1.34]). Among subtypes, the effect of genetically predicted MAP on large artery stroke was attenuated, whereas the effect of genetically predicted PP was augmented with increasing age. Genetically predicted MAP, but not PP, was associated with small vessel stroke and deep intracerebral hemorrhage homogeneously across age deciles. Neither genetically predicted MAP nor PP were associated with lobar intracerebral hemorrhage. Beyond an effect of high MAP at any age on ischemic and hemorrhagic stroke, our results support an independent causal effect of high PP at older ages on large artery stroke. This finding warrants further investigation for the development of stroke preventive strategies targeting pulsatility in later life. [ABSTRACT FROM AUTHOR]

Published
2020
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18. Vascular consequences of inflammation: a position statement from the ESH Working Group on Vascular Structure and Function and the ARTERY Society.

Author

Zanoli, Luca, Briet, Marie, Empana, Jean P, Cunha, Pedro G, Mäki-Petäjä, Kaisa M, Protogerou, Athanase D, Tedgui, Alain, Touyz, Rhian M, Schiffrin, Ernesto L, Spronck, Bart, Bouchard, Philippe, Vlachopoulos, Charalambos, Bruno, Rosa M, Boutouyrie, Pierre, and Association for Research into Arterial Structure, Physiology (ARTERY) Society, the European Society of Hypertension (ESH) Working Group on Vascular Structure and Function, and the European Network for Noninvasive Investigation of Large Arteries

Published
2020
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19. Seasonal variation in blood pressure: Evidence, consensus and recommendations for clinical practice. Consensus statement by the European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability.

Author

Stergiou, George S., Palatini, Paolo, Modesti, Pietro A., Kei Asayama, Asmar, Roland, Bilo, Grzegorz, de la Sierra, Alejandro, Dolan, Eamon, Head, Geoffrey, Kazuomi Kario, Kollias, Anastasios, Manios, Efstathios, Mihailidou, Anastasia S., Myers, Martin, Niiranen, Teemu, Takayoshi Ohkubo, Protogerou, Athanasios, Jiguang Wang, O'Brien, Eoin, and Parati, Gianfranco

Published
2020
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21. BLOOD PRESSURE CLASSIFICATION USING BRACHIAL VERSUS CENTRAL HYPERTENSION PHENOTYPES AND ASSOCIATION WITH LEFT VENTRICULAR MASS – FINDINGS FROM THE I24ABC CONSORTIUM.

Author

Danninger, Kathrin, Weber, Thomas, Wassertheurer, Siegfried, Protogerou, Athanase, Sharman, James E., Sala, Enrique Rodilla, Ortner, Stefan, Athanasopoulou, Elpida, Hametner, Bernhard, Mayer, Christopher, Li, Yan, Pascual, Jose Maria, Karachalias, Fotis, Stergiou, George, Bahous, Sola Aoun, Zhang, Yi, and De La Sierra, Alejandro

Published
2024
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23. ISOLATED SYSTOLIC HYPERTENSION OF YOUTH – FINDINGS FROM THE I24ABC CONSORTIUM.

Author

Danninger, Kathrin, Weber, Thomas, Wassertheurer, Siegfried, Protogerou, Athanase, Sharman, James E., Sala, Enrique Rodilla, Wilkinson, Ian, Hametner, Bernhard, Ortner, Stefan, Mayer, Christoph, Li, Yan, Pascual, Jose Maria, Argyris, Antonios, Athanasopoulou, Elpida, Karachalias, Fotis, Mceniery, Carmel, Stergiou, George, Gomes, Marco Antonio Mota, and Mcdonnell, Barry

Published
2024
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24. 'Apples to oranges' and 'Less is more'.

Author

Argyris, Antonios A., Samara, Stamatia, Blacher, Jacques, Papaioannou, Theodoros G., Stergiou, George S., Vlachopoulos, Charalambos, Wassertheurer, Siegfried, Weber, Thomas, and Protogerou, Athanase D.

Published
2021
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27. Interaction Between Hypertension and Arterial Stiffness.

Author

Safar, Michel E., Asmar, Roland, Benetos, Athanase, Blacher, Jacques, Boutouyrie, Pierre, Lacolley, Patrick, Laurent, Stéphane, London, Gérard, Pannier, Bruno, Protogerou, Athanase, Regnault, Véronique, and French Study Group on Arterial Stiffness

Abstract

The article focuses on the relation between hypertension and arterial stiffness and focuses on the research on Windkessel Model and Aortic Stiffness and the age related changes in the disease.

Published
2018
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32. WHICH SYSTOLIC BLOOD PRESSURE SHOWS CLOSEST ASSOCIATIONS WITH LEFT VENTRICULAR MASS? THE INTERNATIONAL 24 HOUR AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC).

Author

Danninger, Kathrin, Weber, Thomas, Wassertheurer, Siegfried, Protogerou, Athanase, Sherman, James E., Sala, Enrique Rodilla, Muiesan, Maria Lorenza, Giannattasio, Cristina, Hametner, Bernhard, Ortner, Stefan, Li, Yan, Pascual, Jose Maria, McEniery, Carmel, Stergiou, George S., Gomes, Marco Antonio Mota, McDonnell, Barry, Sierra, Alejandro De La, Piskorz, Daniel, Perl, Sabine, and Zhang, Yi

Published
2023
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35. Accuracy of commercial devices and methods for noninvasive estimation of aortic systolic blood pressure a systematic review and meta-analysis of invasive validation studies.

Author

Papaioannou, Theodore G., Karageorgopoulou, Theofani D., Sergentanis, Theodoros N., Protogerou, Athanase D., Psaltopoulou, Theodora, Sharman, James E., Weber, Thomas, Blacher, Jacques, Daskalopoulou, Stella S., Wassertheurer, Siegfried, Khir, Ashraf W., Vlachopoulos, Charalambos, Stergiopulos, Nikolaos, Stefanadis, Christodoulos, Nichols, Wilmer W., and Tousoulis, Dimitrios

Published
2016
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37. Reply.

Author

Papaioannou, Theodore G, Karageorgopoulou, Theofani D, Sergentanis, Theodoros N, Protogerou, Athanase D, Psaltopoulou, Theodora, Sharman, James E, Weber, Thomas, Blacher, Jacques, Daskalopoulou, Stella S, Wassertheurer, Siegfried, Khir, Ashraf W, Vlachopoulos, Charalambos, Stergiopulos, Nikolaos, Stefanadis, Christodoulos, Nichols, Wilmer W, and Tousoulis, Dimitrios

Published
2017
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38. Central aortic pressure calibration: ‘‘a bridge too far’’?--Reply.

Author

Papaioannou, Theodore G., Karageorgopoulou, Theofani D., Sergentanis, Theodoros N., Protogerou, Athanase D., Psaltopoulou, Theodora, Sharman, James E., Weber, Thomas, Blacher, Jacques, Daskalopoulou, Stella S., Wassertheurer, Siegfried, Khir, Ashraf W., Vlachopoulos, Charalambos, Stergiopulos, Nikolaos, Stefanadis, Christodoulos, Nichols, Wilmer W., and Tousoulis, Dimitrios

Published
2017
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47. Role of pulse pressure amplification in arterial hypertension: experts' opinion and review of the data.

Author

Avolio, Alberto P., Bortel, Luc M. Van, Boutouyrie, Pierre, Cockcroft, John R., McEniery, Carmel M., Protogerou, Athanase D., Roman, Mary J., Safar, Michel E., Segers, Patrick, Smulyan, Harold, and Van Bortel, Luc M

Abstract

The article reviews the role of pulse pressure (PP) amplification in arterial hypertension based on research data. It describes the morphology and physiology of the PP wave amplification in the brachial and radial arteries of the upper limb and cites the factors determining PP wave amplification, including aging, gender, height and heart rate. It presents evidence on the link of PP amplification with target organ damage and potential cardiovascular risk. A summary of the effects of antihypertensive drugs on PP amplification is provided.

Published
2009
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