1. Endothelial factors in the pathogenesis and treatment of chronic kidney disease Part II: Role in disease conditions: a joint consensus statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors and the Japanese Society of Hypertension
- Author
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Matthias Barton, Peter W. de Leeuw, Gian Paolo Rossi, Patrick Rossignol, Neeraj Dhaun, Sadayoshi Ito, Luis-Miguel Ruilope, Damiano Rizzoni, Anton H. van den Meiracker, Naoyuki Hasebe, David J. Webb, Teresa Maria Seccia, A.H. Jan Danser, Interne Geneeskunde, RS: CARIM - R3.02 - Hypertension and target organ damage, MUMC+: MA Alg Interne Geneeskunde (9), and Internal Medicine
- Subjects
CHRONIC TRANSPLANT NEPHROPATHY ,Consensus ,endothelium ,TYPE-2 DIABETIC-NEPHROPATHY ,Physiology ,RENAL-ALLOGRAFT REJECTION ,030232 urology & nephrology ,Hyperhomocysteinemia ,Angiogenesis Inhibitors ,Disease ,030204 cardiovascular system & hematology ,Kidney ,Pathogenesis ,preeclampsia ,ANGIOTENSIN-ALDOSTERONE SYSTEM ,03 medical and health sciences ,HEART-BEATING DONORS ,0302 clinical medicine ,Pre-Eclampsia ,Pregnancy ,medicine ,Internal Medicine ,cancer ,Animals ,Humans ,Diabetic Nephropathies ,Renal Insufficiency, Chronic ,Vitamin D ,PORCINE LIVER-TRANSPLANTATION ,Endothelin-1 ,business.industry ,diabetes mellitus ,endothelin ,hyperhomocysteinemia ,hypertension ,kidney ,kidney transplantation ,Cardiology and Cardiovascular Medicine ,Endothelins ,ASYMMETRIC DIMETHYLARGININE ADMA ,RANDOMIZED CONTROLLED-TRIAL ,medicine.disease ,Kidney Transplantation ,Immunology ,Hypertension ,CORONARY-ARTERY-DISEASE ,Female ,Endothelium, Vascular ,PIG PANCREAS TRANSPLANTATION ,business ,Kidney disease - Abstract
After examining in Part I the general mechanisms of endothelial cell injury in the kidney, the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension and the Japanese Society of Hypertension will herein review current knowledge on the role of endothelial dysfunction in multiple disease conditions that affect the kidney, including diabetes mellitus, preeclampsia, solid organ transplantation, hyperhomocysteinemia and antiangiogenic therapy in cancer. The few available randomized controlled clinical trials specifically designed to evaluate strategies for correcting endothelial dysfunction in patients with hypertension and/or chronic kidney disease are also discussed alongside their cardiovascular and renal outcomes.
- Published
- 2018