1. Prognostic value of SUVmax in breast cancer and comparative analyses of molecular subtypes
- Author
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Seungju Lee, Youn Joo Jung, Chang Shin Jung, Moon Il Lee, Dong-Il Kim, Hyun Yul Kim, Kyoungjune Pak, Seong Jang Kim, and Seok Kyung Kang
- Subjects
Oncology ,medicine.medical_specialty ,Axillary lymph nodes ,Breast Neoplasms ,Immunophenotyping ,Breast cancer ,breast cancer ,Predictive Value of Tests ,Survival prognosis ,Internal medicine ,medicine ,Humans ,In patient ,prognostic value ,medicine.diagnostic_test ,business.industry ,Hazard ratio ,SUVmax ,General Medicine ,medicine.disease ,Primary tumor ,meta-analysis ,medicine.anatomical_structure ,Positron emission tomography ,Meta-analysis ,Female ,business ,Systematic Review and Meta-Analysis ,Research Article - Abstract
Background: To assess the prognostic capability of the maximum standardized uptake values (SUVmax) measured in the primary tumor and axillary lymph nodes (ALNs) by pretreatment fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography and analyze outcomes according to the molecular breast cancer subtypes. Methods: The databases were systematically searched using keywords for breast cancer, positron emission tomography/computed tomography, and SUVmax; the extracted studies reported at least 1 form of survival data, event-free survival (EFS) and overall survival. Comparative analyses of the pooled hazard ratios (HRs) for EFS and overall survival were performed to assess their correlations with SUVmax. The pooled HR was estimated using random-effects model according to the results of heterogeneity. Results: Thirteen eligible studies comprising 3040 patients with breast cancer were included. The pooled HRs of high SUVmax in the primary tumor and ALN were 3.01 (95% CI 1.83–4.97, P
- Published
- 2021