1. No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia.
- Author
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Nyegaard M, Demontis D, Thestrup BB, Hedemand A, Sørensen KM, Hansen T, Werge T, Hougaard DM, Yolken RH, Mortensen PB, Mors O, and Børglum AD
- Subjects
- CD48 Antigen, Case-Control Studies, Humans, Antigens, CD immunology, Endogenous Retroviruses genetics, Polymorphism, Single Nucleotide, Schizophrenia immunology, Schizophrenia virology
- Abstract
The human endogenous retrovirus HERV-K18 is located within intron 1 of CD48 on chromosome 1q and is still active in the human genome. Genetic variation in HERV-K18 single-nucleotide polymorphisms (SNPs) has previously been associated with an increased risk of schizophrenia (SZ) and with type 2 diabetes (T2D) among individuals with SZ. Here, we present a replication study of association of two SNPs in HERV-K18 and 19 tagSNPs in CD48 with (a) SZ and (b) T2D in patients with SZ in two Danish samples (total number of cases=750 and controls=1214). No association was found with SZ or with T2D among individuals with SZ for any of the investigated SNPs. However, one HERV-K18 SNP showed a tendency toward an association with T2D in younger SZ patients, in agreement with previous findings, but due to a very low sample size, this result needs to be further investigated.
- Published
- 2012
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