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3. Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study. Parkinson Study Group.

Author

Vatassery GT, Fahn S, and Kuskowski MA

Subjects
Antioxidants therapeutic use, Antiparkinson Agents therapeutic use, Dose-Response Relationship, Drug, Double-Blind Method, Humans, Selegiline therapeutic use, Vitamin E therapeutic use, Parkinson Disease drug therapy, Vitamin E administration & dosage, Vitamin E cerebrospinal fluid
Abstract

Alpha-Tocopherol concentrations were determined in the CSF of patients with early untreated Parkinson's disease receiving 2,000 IU vitamin E orally per day. After treatment the concentrations increased significantly (p < 0.001) by 76+/-10 (SE)%. The net increases in CSF alpha-tocopherol concentrations after treatment showed a significant positive correlation with the number of days of vitamin E ingestion (p < 0.001). Thus, high-dose vitamin E treatment results in elevating CSF vitamin E levels and possibly brain vitamin E levels.

Published
1998
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