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Objectives: Links between periodontal diseases and systemic diseases have been well documented by epidemiological studies. Cardiovascular diseases are one of the main causes of morbidity and mortality in the European countries, including Romania. One focus of interest is atherosclerosis, the underlying event of cardiovascular diseases due to its serious health impact. The aim of this study was to analyze a possible association between ischemic stroke and periodontitis by marginal bone loss assessment on panoramic radiography (PR), Dental CT or CBCT. Material and methods: 103 patients, 28 to 50 years old, with recent history of ischemic stroke or transient ischemic attack diagnosed by specialist doctors (neurologists) were selected. Several parameters were evaluated in first five days in the dental office according to the health questionnaire and the recommended blood tests (cholesterol, triglycerides, complete hemoleucogram, C-reactive protein etc.). The same examiner and also two radiologist assessed the odontal and periodontal status of each patient on the PR, Dental CT or CBCT. We analyzed irredeemable teeth, periapical lesions, interradicular lesions, 4-5mm bone loss from the enamel-cement junction (ECJ) and >6mm bone loss from the enamel-cement junction (ECJ). Results: The study group analyzed by PR, Dental CT or CBCT presented high percents of irredeemable teeth (12%), teeth with periapical lesions (>3 mm; 3%), interradicular lesions (10%), 4-5 mm proximal bone loss (11%) and >6 mm bone loss (19%) associated with different localization of ischemic stroke. Conclusions: The present study confirms the existence of correlations between endodontic infections, periodontal infections demonstrated by panoramic radiography, CT/CBCT and ischemic stroke.