1. Long and Short-Term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19
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Elnaz Shaseb, Saba Ghaffary, Alireza Garjani, Elnaz Zoghi, Nasrin Maleki Dizaji, Somaieh Soltani, Parvin Sarbakhsh, Mohammad Hossein Somi, Parya Valizadeh, Ali Taghizadieh, Masood Faghihdinevari, Mojtaba Varshochi, Behrooz Naghili, Zhinous Bayatmakoo, Parviz Saleh, Sepehr Taghizadeh, Mehdi Haghdoost, Hamid Owaysi, Fatemeh Ravanbakhsh Ghavghani, Mohammad Kazem Tarzamni, Rojin Moradi, Fateme Javan Ali Azar, Saeid Shabestari khiabani, Ardavan Ghazanchaei, Sana Hamedani, and Shahabeddin Hatefi
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Pharmaceutical Science ,General Pharmacology, Toxicology and Pharmaceutics - Abstract
Introduction: The aim of the study is to evaluate the effect of metformin in complication improvement of hospitalized patients with COVID-19. Methods: This was a randomized clinical trial that involved 189 patients with confirmed COVID-19 infection. Patients in the intervention group received metformin-500 mg twice daily. Patients who received metformin before admission were excluded from the control group. Patients who were discharged before taking at least 2000 mg of metformin were excluded from the study. Primary outcomes were vital signs, need for ICU admission, need for intubation, and mortality. Results: Data showed that patients with diabetes with previous metformin in their regimen had lower percentages of ICU admission and death in comparison with patients without diabetes (11.3% vs. 26.1% (p=0.014) and 4.9% vs. 23.9% (p=
- Published
- 2022
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