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Novel Prednisolone sodium phosphate loaded hydrolyzed acrylamide grafted polyvinyl alcohol (Hy-PVA-g- AAm) microspheres were fabricated by using spray drying method. The primary objective of the work was to synthesize Hy-PVA-g-AAm with pH dependent swelling and its microspheres. The microspheres were evaluated by scanning electron microscopy (SEM) as well as fourier-transform infrared spectroscopy (FTIR). The influence of processing conditions on particle size, drug entrapment efficiency and swelling behaviour of the developed microspheres were studied. The microspheres were filled in enteric coated hard gelatine capsules to carry out the dissolution. The average particle size of the microspheres varied between 60-100 µm and the entrapment efficiency ranged between 84 to 94%. The microspheres exhibited pH responsive swelling with appreciably high swelling under colonic pH of 7.4 compared to acidic condition. The microspheres exhibited drug release in pH dependent manner. The cumulative percent drug release was found to be less than 20% in slightly acidic pH 6.8 resembling intestine and comparatively higher drug release in pH 7.4. The formulation followed Korsemeyer-Peppas kinetics with Non-Fickian diffusion after an adequate lag period. [ABSTRACT FROM AUTHOR]

Formulation and evaluation of oral dispersible film of domperidone was used as the primary objective of the present work, in order that can be successfully used for the management of emesis. In the work done, the films were prepared by solvent casting technique and in vitro performance was evaluated by the usual pharmacopoeial and unofficial tests. The oral dispersible film formed was found to be disintegrated within 1 minute. The thickness, drug content, tensile strength, surface pH, disintegration time (DT), mouth dissolving time and release profile of oral dispersible films were evaluated, and the best results were obtained at the formulation F3 containing Hydroxypropyl Methylcellulose (HPMC) E5 LV (100 mg), citric acid (20 mg), aspartame (5mg) and Polyethylene glycol (PEG)-400. The Formulation F3 showed 100.11% release within 10 minutes. As follows, the developed oral dispersible film of domperidone might be clinically used for fast release of drug in mouth, for better drug utilization and improved patient compliance. [ABSTRACT FROM AUTHOR]