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Significance: A review of therapeutic effects in preclinical and clinical studies suggests that concordance between large animal (pig=78%), small laboratory animal (53%) and in vitro (57%) results with those observed in humans is only partial. Pig models of wound healing provide major advantages over other animal models. Since the vast majority of wound-healing research is done in rodents and in vitro , the low concordance rate is a significant impediment to research that will have any clinical impact., Critical Issues: To generate clinically relevant experimental data, hypothesis generation should begin, or at least involve human wound tissue samples. Such tissue could be used to test a predetermined hypothesis generated based on, say, murine data. Alternatively, such tissue could be analyzed using high-throughput cell biology techniques ( e.g ., genomics, proteomics, or metabolomics) to identify novel mechanisms involved in human wounds. Once the hypothesis has been formulated and confirmed using human samples, identification of these same mechanisms in animals represents a valid approach that could be used for more in-depth investigations and experimental manipulations not feasible with humans., Future Directions: This consensus statement issued by the Wound Healing Society symposium strongly encourages all wound researchers to involve human wound tissue validation studies to make their animal and cell biology studies more translationally and clinically significant. more...

We sought to review the role of oxygen in wound healing, with an emphasis on the role tissue oximetry has played in clinical advances in the care of patients with wounds. Oxygen is required for wound healing. Hypoxia sufficient to impair healing is common in wounds, frequently resulting from sympathetically induced vasoconstriction. Correction or prevention of vasoconstriction, as well as provision of increased inspired oxygen in well-perfused patients, has been shown in randomized, controlled clinical trials to improve wound outcomes. Our understanding of the role of oxygen in wound healing has been fueled by tissue oximetry. Advances in technology will lead to further advances in the management of patients with wounds. more...