1. Additive Fabrication of a Vascular 3D Phantom for Stereotactic Radiosurgery of Arteriovenous Malformations
- Author
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Andrea Gioppo, P. Gallo, Elena De Martin, Paolo Milani, Maria Luisa Fumagalli, Tommaso Santaniello, Giuseppe Faragò, Francesco Cavaliere, Maria Grazia Bruzzone, Lorenzo Gentili, Elisa Legnani, Francesco Padelli, and Federico Pezzotta
- Subjects
business.industry ,Materials Science (miscellaneous) ,medicine.medical_treatment ,Arteriovenous malformation ,Original Articles ,equipment and supplies ,medicine.disease ,Industrial and Manufacturing Engineering ,Imaging phantom ,Radiosurgery ,law.invention ,law ,medicine ,business ,Nuclear medicine ,Stereolithography - Abstract
In this study, an efficient methodology for manufacturing a realistic three-dimensional (3D) cerebrovascular phantom resembling a brain arteriovenous malformation (AVM) for applications in stereotactic radiosurgery is presented. The AVM vascular structure was 3D reconstructed from brain computed tomography (CT) data acquired from a patient. For the phantom fabrication, stereolithography was used to produce the AVM model and combined with silicone casting to mimic the brain parenchyma surrounding the vascular structure. This model was made with tissues-equivalent materials for radiology. The hollow vascular system of the phantom was filled with a contrast agent usually employed on patients for CT scans. The radiological response of the phantom was tested and compared with the one of the clinical case. The constructed model demonstrated to be a very accurate physical representation of the AVM and its vasculature and good morphological consistency was observed between the model and the patient-specific source anatomy. These results suggest that the proposed method has potential to be used to fabricate patient-specific phantoms for neurovascular radiosurgery applications and medical research.
- Published
- 2021