1. Efficacy of Epigallocatechin-3-Gallate and Amla (Emblica officinalis) Extract for the Treatment of Diabetic-Uremic Patients.
- Author
-
Tung-Sheng Chen, Show-Yih Liou, Hsi-Chin Wu, Fuu-Jen Tsai, Chang-Hai Tsai, Chih-Yang Huang, and Yen-Lin Chang
- Subjects
- *
BLOOD sugar analysis , *TREATMENT of chronic kidney failure , *ALTERNATIVE medicine , *ANALYSIS of variance , *ANTIOXIDANTS , *BIOMARKERS , *BIOPHYSICS , *BLOOD testing , *DIABETES , *HEMODIALYSIS , *INFLAMMATION , *KIDNEY function tests , *LIVER function tests , *LONGITUDINAL method , *RESEARCH methodology , *ORAL drug administration , *HEALTH outcome assessment , *RESEARCH funding , *T-test (Statistics) , *UREMIA , *GREEN tea , *COMORBIDITY , *PHYTOCHEMICALS , *PLANT extracts , *OXIDATIVE stress , *TREATMENT effectiveness , *TREATMENT duration - Abstract
AbstractUremic patients with diabetes suffer from high levels of oxidative stress due to regular hemodialysis therapy (neutrophil activation induced by hemo-incompatibility between the hemodialyser and blood) and complications associated with diabetes. Several plasma biomarkers were screened in 13 uremic diabetic patients after receiving the mixture of (–)-epigallocatechin gallate (EGCG), a major component of green tea extract, and Amla extract (AE), from Emblica officinalis, the Indian gooseberry, for 3 months. We found that oral administration of a 1:1 mixture of EGCG and AE for 3 months significantly improved antioxidant defense as well as diabetic and atherogenic indices in uremic patients with diabetes. Furthermore, no significant changes in hepatic function, renal function, or inflammatory responses were observed. These results suggest that a 1:1 combination of EGCG and AE is a safe and effective treatment for uremic patients with diabetes. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF