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Start Over Author "Hui-Ping Chen" Publisher mary ann liebert, inc.
2 results on '"Hui-Ping Chen"'

1. Attitudes of Chinese Oncology Physicians Toward Death with Dignity

Author

Yu-qing Wang, Ting-wu Yi, Jie Zhang, Yu Jiang, Boyan Huang, Hui-ping Chen, Zong-yan Zhang, Jie Liu, and Yao-Tiao Deng

Subjects
Oncology, Mainland China, medicine.medical_specialty, China, Attitude of Health Personnel, Death with dignity, MEDLINE, Terminally ill, Living Wills, organization, Medical Oncology, Suicide, Assisted, Right to die, 03 medical and health sciences, 0302 clinical medicine, Nursing, Internal medicine, organization.non_profit_organization, Neoplasms, Surveys and Questionnaires, medicine, Humans, 030212 general & internal medicine, Physician's Role, General Nursing, Effective response, Legalization, business.industry, Euthanasia, Right to Die, General Medicine, humanities, Anesthesiology and Pain Medicine, 030220 oncology & carcinogenesis, Family medicine, Brief Reports, business
Abstract

Background: Death with dignity (DWD) refers to the refusal of life-prolonging measures for terminally ill patients by “living wills” forms in advance. More and more oncology physicians are receiving DWD requests from advance cancer patients in mainland China. Objective: The study objective was to investigate the attitudes of Chinese oncology physicians toward the legalization and implementation of DWD. Methods: A questionnaire investigating the understanding and attitudes toward DWD was administered to 257 oncology physicians from 11 hospitals in mainland China. Results: The effective response rate was 86.8% (223/257). The majority of oncology physicians (69.1%) had received DWD requests from patients. Half of the participants (52.5%) thought that the most important reason was the patients' unwillingness to maintain survival through machines. One-third of participants (33.0%) attributed the most important reason to suffering from painful symptoms. Most oncology physicians (78.9%) had knowledge about DWD. A fifth of respondents did not know the difference between DWD and euthanasia, and a few even considered DWD as euthanasia. The majority of oncology physicians supported the legalization (88.3%) and implementation (83.9%) of DWD. Conclusions: Many Chinese oncology physicians have received advanced cancer patients' DWD requests and think that DWD should be legalized and implemented. Chinese health management departments should consider the demands of physicians and patients. It is important to inform physicians about the difference between DWD and euthanasia, as one-fifth of them were confused about it.

Published
2016

2. BRAFV600EMutation and X-Linked Inhibitor of Apoptosis Expression in Papillary Thyroid Carcinoma.

Author

Li-Qun Gu, Feng-Ying Li, Lin Zhao, Yun Liu, Xun-Xiong Zang, Tian-Xiang Wang, Hui-Ping Chen, Guang Ning, and Yong-Ju Zhao

Subjects
GENETIC mutation, LINKAGE (Genetics), APOPTOSIS, THYROID cancer, GENE expression, CANCER genetics, CANCER invasiveness, LOGISTIC regression analysis
Abstract

Background:The BRAF mutation V600E (BRAFV600E) is the most common genetic alteration in papillary thyroid carcinoma (PTC), while overexpression of X-linked inhibitor of apoptosis (XIAP) has been found in various tumors. Both of these events are implicated in carcinogenesis, tumor progression, recurrence, etc. There are few reports, however, of the BRAFV600Emutation and XIAP overexpression in PTC patients. The aim of this study was to investigate the frequency of the BRAFV600Emutation in PTC and its relationship to clinicopathological parameters and the expression of XIAP.Methods:Genomic DNA was extracted from 123 paraffin-embedded PTC tumor tissue samples and amplified for analysis of the V600E mutation in exon 15 of the BRAF gene by polymerase chain reaction. XIAP expression was examined by immunohistochemical methods in 46 PTCs, 18 benign nodular goiters, and 10 Hashimoto''s thyroiditis samples.Results:The BRAFV600Emutation was found in 34.1% of PTC, and was especially prevalent in the classic type. BRAFV600Ewas significantly correlated with younger age at diagnosis (p= 0.026), tumor size (p= 0.009), and histological variants (p= 0.024). There was a trend towards association with extrathyroidal invasion (p= 0.067). By logistic regression analysis, a significant relationship was found between tumor size and the BRAFV600Emutation (p= 0.03). XIAP was expressed in 82.6% of PTCs, which was a higher percentage than observed in the group of benign thyroid disorders (35.7%, p< 0.001). Neither the intensity (p= 0.611) nor the extent (p= 0.723) of XIAP staining was correlated with the presence of BRAFV600Ein PTC patients.Conclusions:These data indicate that BRAFV600Eis associated some of the aggressive clinicopathological features of PTC including younger age at diagnosis, larger tumor size, and classic histological type, as well as also extrathyroidal invasion. XIAP-positive staining was more prevalent in PTCs than in the benign thyroid disorders. Although BRAFV600Eand XIAP expression are commonly seen in PTC, their presence together seems unrelated. [ABSTRACT FROM AUTHOR]

Published
2009
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