1. Temporal Profile of Microtubule-Associated Protein 2: A Novel Indicator of Diffuse Brain Injury Severity and Early Mortality after Brain Trauma
- Author
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Ilona M. Schmalfuss, Kevin K.W. Wang, H. Julia Hannay, Claudia S. Robertson, Ronald L. Hayes, Gretchen M. Brophy, Andrea Gabrielli, Linda Papa, Steven A. Robicsek, and Shelley C. Heaton
- Subjects
0301 basic medicine ,Ventriculostomy ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,Traumatic brain injury ,medicine.medical_treatment ,Cohort Studies ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Cerebrospinal fluid ,Microtubule-associated protein 2 ,medicine ,Brain Injuries, Diffuse ,Humans ,Prospective Studies ,Prospective cohort study ,Aged ,Aged, 80 and over ,business.industry ,Diffuse axonal injury ,Glasgow Coma Scale ,Original Articles ,Middle Aged ,medicine.disease ,Surgery ,030104 developmental biology ,Anesthesia ,Brain Injuries ,Female ,Neurology (clinical) ,Diffuse brain injury ,business ,Microtubule-Associated Proteins ,030217 neurology & neurosurgery ,Biomarkers - Abstract
This study compared cerebrospinal fluid (CSF) levels of microtubule-associated protein 2 (MAP-2) from adult patients with severe traumatic brain injury (TBI) with uninjured controls over 10 days, and examined the relationship between MAP-2 concentrations and acute clinical and radiologic measures of injury severity along with mortality at 2 weeks and over 6 months. This prospective study, conducted at two Level 1 trauma centers, enrolled adults with severe TBI (Glasgow Coma Scale [GCS] score ≤8) requiring a ventriculostomy, as well as controls. Ventricular CSF was sampled from each patient at 6, 12, 24, 48, 72, 96, 120, 144, 168, 192, 216, and 240 h following TBI and analyzed via enzyme-linked immunosorbent assay for MAP-2 (ng/mL). Injury severity was assessed by the GCS score, Marshall Classification on computed tomography (CT), Rotterdam CT score, and mortality. There were 151 patients enrolled—130 TBI and 21 control patients. MAP-2 was detectable within 6 h of injury and was significantly elevated compared with controls (p
- Published
- 2018