1. Differential Antibody Response to SARS-CoV-2 Antigens in Recovered and Deceased Iranian COVID-19 Patients.
- Author
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Maghsood, Faezeh, Hassani, Danesh, Salimi, Vahid, Kardar, Gholam Ali, Khoshnoodi, Jalal, Ghaderi, Abbas, Raeeskarami, Seyyed Reza, Rostamian, Abdorrahman, Seyyedsalehi, Monireh Sadat, Ahmadi Fesharaki, Raoufeh, Jeddi-Tehrani, Mahmood, Zarnani, Amir-Hassan, Amiri, Mohammad Mehdi, and Shokri, Fazel
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COVID-19 , *ANTIBODY formation , *IRANIANS , *IMMUNOGLOBULIN M , *SARS-CoV-2 , *IMMUNOGLOBULIN G , *HUMORAL immunity - Abstract
The coronavirus infectious disease 2019 (COVID-19), which is initiated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has imposed critical challenges to global health. Understanding the kinetic of SARS-CoV-2-specific IgM and IgG responses in different subsets of COVID-19 patients is crucial to get insight into the humoral immune response elicited against the virus. We investigated IgM and IgG responses against SARS-CoV-2 nucleocapsid (N) and receptor-binding domain (RBD) of spike protein in two groups of recovered and deceased COVID-19 patients. The levels of IgM and IgG specific to N and RBD proteins were detected by ELISA. N- and RBD-specific IgM was higher in deceased patients in comparison with recovered patients, while there was no significant difference in N- and RBD-specific IgG between the two groups. A significant correlation was observed between IgG and IgM titers against RBD and N, in both groups of patients. These results argue against impaired antibody response in deceased COVID-19 patients. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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