1. Dopamine D1 Receptor Gene Polymorphism Is Associated with Myocardial Infarction.
- Author
-
Zhao, Zhuoxian, Li, Sheyu, Zhang, Li, Deng, Xiangbing, Chen, Tie, Zeng, Ke, and Mo, Xianming
- Subjects
DOPAMINE receptors ,GENETIC polymorphisms ,MYOCARDIAL infarction ,NEUTROPHILS ,HEART cells ,POLYMERASE chain reaction ,ALLELES - Abstract
Dopamine D1 receptor ( DRD1) gene is associated with the pathogenesis of myocardial infarction (MI) in aspects of plaque rupture, platelet aggregation, and neutrophil-mediated injury of cardiac myocytes. Thus, the study was designed to explore whether the A-48G polymorphism of the DRD1 gene was associated with MI. The genotype of the DRD1A-48G polymorphism was determined by polymerase chain reaction in the 602 Han Chinese participants, 255 MI patients and 347 controls without MI. A significant association was found between the A-48G polymorphism of DRD1 and MI (genotype model: χ
2 =13.2, unadjusted p=0.001; χ2 =13.9, adjusted p=0.0002; dominant model: adjusted OR 2.05, 95%CI 1.40-3.00, p=0.0002; recessive model: adjusted OR 2.34, 95%CI 1.01-5.39, p=0.047). The G allele was a risk-increased allele for MI (unadjusted OR 1.83, 95%CI 1.34-2.50, p=0.0001; adjusted OR 1.94, 95%CI 1.40-2.68, p=0.00007). Thus, the study demonstrated the significant association between A-48G polymorphism of the DRD1 gene and MI. [ABSTRACT FROM AUTHOR]- Published
- 2012
- Full Text
- View/download PDF