1. Identification of a highly divergent HIV type 2 and proposal for a change in HIV type 2 classification.
- Author
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Damond F, Worobey M, Campa P, Farfara I, Colin G, Matheron S, Brun-Vézinet F, Robertson DL, and Simon F
- Subjects
- Adult, Animals, Cote d'Ivoire, DNA, Viral chemistry, DNA, Viral isolation & purification, France, HIV Infections transmission, HIV-2 isolation & purification, Haplorhini, Humans, Male, Molecular Sequence Data, Phylogeny, Proviruses genetics, Proviruses isolation & purification, Sequence Analysis, DNA, Simian Immunodeficiency Virus genetics, Terminology as Topic, Zoonoses, Genome, Viral, HIV Infections virology, HIV-2 classification, HIV-2 genetics
- Abstract
We report the complete genome sequence of a highly divergent strain of human immunodeficiency virus type 2 (HIV-2), 96FR12034, identified in France from a patient of West African origin. This lineage, H, represents only the third definitive instance of a monkey-to-human transfer of SIVsm that has given rise to pathogenic HIV-2. As the different "subtypes" of HIV-2 are analogous to the different groups of HIV-1 we propose that HIV-2 subtypes henceforth by renamed groups in agreement with the HIV Nomenclature Committee. The single-strain lineages C to G and the 96FR12034 lineage identified here should be considered only as putative groups until related strains are identified that confirm circulation of these viruses in the human population.
- Published
- 2004
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