1. Short communication: Emergence of novel A/G recombinant HIV-1 strains in Argentina.
- Author
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Fernández MF, Golemba MD, Terrones C, Paradiso P, Nassif JC, Bologna R, Mangano A, Sen L, and Aulicino PC
- Subjects
- Adult, Argentina epidemiology, Child, Child, Preschool, Cluster Analysis, Female, HIV Infections epidemiology, HIV-1 isolation & purification, Humans, Infant, Infant, Newborn, Molecular Sequence Data, Phylogeny, Sequence Analysis, DNA, pol Gene Products, Human Immunodeficiency Virus genetics, Genetic Variation, HIV Infections virology, HIV-1 classification, HIV-1 genetics, Recombination, Genetic
- Abstract
The predominant circulating HIV-1 strains in South America are subtype B and B/F recombinants with different distributions among countries. However, the emergence of other subtypes is a matter of concern and needs continuous monitoring. We identified three different A/G recombinants in Argentina, two of them in vertically infected children from unlinked mothers and one in an adult female. HIV-1 pol sequences from the children showed novel A/G recombination patterns and no phylogenetic relationship with previously reported South American A/G sequences. The third A/G recombinant was a CRF06_cpx with African origin. The detection of new or unusual subtypes is important to avoid false-negative PCR HIV-1 early diagnosis due to detection failures and for future vaccine development.
- Published
- 2015
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