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Your search keyword '"Gretchen M. Brophy"' showing total 5 results
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5 results on '"Gretchen M. Brophy"'

1. Intravenous Versus Oral Acetaminophen Use in Febrile Neurocritical Care Patients

Author

Robert E D'Eramo, Melissa Sandler, Gretchen M. Brophy, Perry Taylor, and Pramit Nadpara

Subjects
medicine.medical_specialty, Neurological injury, Fever, urogenital system, business.industry, digestive, oral, and skin physiology, Neurointensive care, Critical Care and Intensive Care Medicine, Acetaminophen, Anesthesiology and Pain Medicine, Hypothermia, Induced, Intensive care, parasitic diseases, embryonic structures, Emergency medicine, Humans, Medicine, Administration, Intravenous, business, Ischemic Stroke, Retrospective Studies, medicine.drug
Abstract

The use of intravenous (IV) acetaminophen (APAP) for fever has not been thoroughly studied in neurocritical care (NCC) patients, in whom a temperature of ≥38°C is associated with poor outcomes and treatment to normothermia is common practice. This retrospective study evaluated NCC patients admitted between May 1, 2012, and April 30, 2013, and received at least one dose of IV or oral (PO) APAP for a body temperature of ≥38°C. The primary aim of this study was to compare the reduction in body temperature (RIT) between IV and PO APAP, calculated as the change in temperature before and 0.5, 1, 2, 3, and 6 hours after administration. Descriptive statistics were used to assess use characteristics, and Kruskal-Wallis and Mann-Whitney

Published
2022

2. Unique Uses of Cooling Strategies

Author

Kees H. Polderman, Byron C. Drumheller, Gretchen M. Brophy, and Michael C. Kurz

Subjects
Anesthesiology and Pain Medicine, Hypothermia, Induced, business.industry, Shivering, Systems engineering, Humans, Medicine, Critical Care and Intensive Care Medicine, business, Body Temperature
Published
2019

3. Targeted Temperature Management in Nursing Care

Author

Gretchen M, Brophy, David A, Hildebrandt, Elizabeth A, Moore, and Todd J, Van de Bussche

Subjects
Anesthesiology and Pain Medicine, Hypothermia, Induced, Humans, Nursing Care, Critical Care and Intensive Care Medicine
Published
2019

4. Temperature Management in Neurological and Neurosurgical Intensive Care Unit

Author

Patrick Lyden, Gretchen M. Brophy, Nicolas Deye, and Christopher M. Horn

Subjects
03 medical and health sciences, 0302 clinical medicine, Anesthesiology and Pain Medicine, 030208 emergency & critical care medicine, Critical Care and Intensive Care Medicine, 030217 neurology & neurosurgery
Published
2016

5. Lateral Ventricle Volume Asymmetry Predicts Midline Shift in Severe Traumatic Brain Injury

Author

Ronald L. Hayes, Shelley C. Heaton, Andras Buki, Attila Schwarcz, Steven A. Robicsek, Andrea Gabrielli, Claudia S. Robertson, Ilona M. Schmalfuss, Linda Papa, Arnold Tóth, H. Julia Hannay, Kevin K.W. Wang, and Gretchen M. Brophy

Subjects
Adult, Male, Ventriculostomy, medicine.medical_specialty, Adolescent, Traumatic brain injury, medicine.medical_treatment, Sensitivity and Specificity, Severity of Illness Index, Young Adult, Blunt, Midline shift, Lateral Ventricles, medicine, Humans, Aged, Aged, 80 and over, Receiver operating characteristic, business.industry, Trauma center, Original Articles, Odds ratio, Middle Aged, medicine.disease, Radiography, medicine.anatomical_structure, Ventricle, Brain Injuries, Female, Neurology (clinical), Radiology, business
Abstract

Midline shift following severe traumatic brain injury (sTBI) detected on computed tomography (CT) scans is an established predictor of poor outcome. We hypothesized that lateral ventricular volume (LVV) asymmetry is an earlier sign of developing asymmetric intracranial pathology than midline shift. This retrospective analysis was performed on data from 84 adults with blunt sTBI requiring a ventriculostomy who presented to a Level I trauma center. Seventy-six patients underwent serial CTs within 3 h and an average of three scans within the first 10 d of sTBI. Left and right LVVs were quantified by computer-assisted manual volumetric measurements. LVV ratios (LVR) were determined on the admission CT to evaluate ventricular asymmetry. The relationship between the admission LVR value and subsequent midline shift development was tested using receiver operating characteristic (ROC) analysis, and odds ratio (OR) and relative risk tests. Sixty patients had no >5 mm midline shift on the initial admission scan. Of these, 15 patients developed it subsequently (16 patients already had >5 mm midline shift on admission scans). For >5 mm midline shift development, admission LVR of >1.67 was shown to have a sensitivity of 73.3% and a specificity of 73.3% (area under the curve=0.782; p1.67 as exposure yielded an OR of 7.56 (p

Published
2015

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